Protein Information

Name ERK2
Synonyms ERK; P40; ERK 2; ERK2; ERT 1; ERT1; Extracellular signal regulated kinase 2; MAP kinase 2…

Compound Information

Name sodium arsenite
CAS sodium arsenenite

Reference List

PubMed Abstract RScore(About this table)
12482858 Duyndam MC, Hulscher ST, van der Wall E, Pinedo HM, Boven E: Evidence for a role of p38 kinase in hypoxia-inducible factor 1-independent induction of vascular endothelial growth factor expression by sodium arsenite. J Biol Chem. 2003 Feb 28;278(9):6885-95. Epub 2002 Dec 13.

By using kinase inhibitors in OVCAR-3 cells, both effects of sodium arsenite were found to be independent of phosphatidylinositol 3-kinase and p44/p42 MAPKS but were attenuated by inhibition of p38 MAPK.
31(0,1,1,1) Details
7768904 Trigon S, Morange M: Different carboxyl-terminal domain kinase activities are induced by heat-shock and arsenite. J Biol Chem. 1995 Jun 2;270(22):13091-8.

We have previously shown that in HeLa cells a protein kinase (HS-CTD kinase) activity is induced rapidly after a heat or sodium arsenite shock.
Mono Q chromatography allows the separation of five stress-induced CTD kinase activities, two of which coelute with active mitogen-activated protein kinase forms revealed by Western blotting with anti ERK1-ERK2 antibodies.
2(0,0,0,2) Details
15362974 McNeill H, Knebel A, Arthur JS, Cuenda A, Cohen P: A novel UBA and UBX domain protein that binds polyubiquitin and VCP and is a substrate for SAPKs. Biochem J. 2004 Dec 1;384(Pt 2):391-400.


Termed SAKS1 (SAPK substrate-1), it was phosphorylated efficiently at Ser200 in vitro by SAPK3/p38gamma, SAPK4/p38delta and JNK (c-Jun N-terminal kinase), but weakly by SAPK2a/p38alpha, SAPK2b/p38beta2 or ERK (extracellular-signal-regulated kinase) 2.
1(0,0,0,1) Details
9671412 Lim CP, Jain N, Cao X: Stress-induced immediate-early gene, egr-1, involves activation of p38/JNK1. Oncogene. 1998 Jun 4;16(22):2915-26.


Here we report that in NIH3T3 cells, egr-1 is induced by various stress treatments such as heat shock, sodium arsenite, ultraviolet (U.V.) radiation, and anisomycin. p38 and JNK1, but not ERK2, were activated by these stress treatments.
0(0,0,0,0) Details
12637567 Kietzmann T, Samoylenko A, Immenschuh S: Transcriptional regulation of heme oxygenase-1 gene expression by MAP kinases of the JNK and p38 pathways in primary cultures of rat hepatocytes. J Biol Chem. 2003 May 16;278(20):17927-36. Epub 2003 Mar 11.


Heme oxygenase-1 (HO-1) gene expression is induced by various oxidative stress stimuli including sodium arsenite.
0(0,0,0,0) Details