Protein Information

Name cHO 1
Synonyms CHO 1; CHO1; KIF23; KNSL 5; KNSL5; Kinesin family member 23; Kinesin like 5; Kinesin like protein 5…

Compound Information

Name sodium arsenite
CAS sodium arsenenite

Reference List

PubMed Abstract RScore(About this table)
10942197 Lu TH, Shan Y, Pepe J, Lambrecht RW, Bonkovsky HL: Upstream regulatory elements in chick heme oxygenase-1 promoter: a study in primary cultures of chick embryo liver cells. Mol Cell Biochem. 2000 Jun;209(1-2):17-27.

Because sodium arsenite is known to cause oxidative stress and because activation of AP-1 proteins has been shown to be a key step in the oxidative stress response pathway, we also explored the possibility that the induction of the cHO-1 gene by sodium arsenite is mediated through oxidative stress pathway (s) by activation of AP-1 proteins.
105(0,3,5,5) Details
9511760 Lu TH, Lambrecht RW, Pepe J, Shan Y, Kim T, Bonkovsky HL: Molecular cloning, characterization, and expression of the chicken heme oxygenase-1 gene in transfected primary cultures of chick embryo liver cells. Gene. 1998 Jan 30;207(2):177-86.

Studies with deletion mutants, consisting of various lengths of the cHO-1 promoter region, indicated that there are two regions important for sodium arsenite induction, one located between residues -1642 and -1293, and the second located in the first 263 base pairs of the cHO-1 promoter.
10(0,0,1,5) Details