| Name | 5 lipoxygenase |
|---|---|
| Synonyms | 5 lipoxygenase; 5 LO; 5LPG; ALOX 5; ALOX5; Arachidonate 5 lipoxygenase; Arachidonate 5 lipoxygenase variant; LOG 5… |
| Name | sodium arsenite |
|---|---|
| CAS | sodium arsenenite |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 10779545 | Werz O, Klemm J, Samuelsson B, Radmark O: 5-lipoxygenase is phosphorylated by p38 kinase-dependent MAPKAP kinases. Proc Natl Acad Sci U S A. 2000 May 9;97(10):5261-6. When polymorphonuclear leukocytes were incubated with sodium arsenite (strong activator of 5-LO kinases), platelet-activating factor and exogenous AA, there was a 4-fold increase in 5-LO activity as compared with incubations with only platelet-activating factor and AA. |
118(1,2,2,8) | Details |
| 11807011 | Werz O, Burkert E, Samuelsson B, Radmark O, Steinhilber D: Activation of 5-lipoxygenase by cell stress is independent in human polymorphonuclear leukocytes. Blood. 2002 Feb 1;99(3):1044-52. This study showed that various forms of cell stress, such as chemical stress (sodium arsenite), osmotic stress, or heat shock lead to substantial formation of 5-LO products in freshly isolated human polymorphonuclear leukocytes (PMNLs), when exogenous (10 microM) was present. |
40(0,1,1,10) | Details |
| 17704828 | Fischer L, Hornig M, Pergola C, Meindl N, Franke L, Tanrikulu Y, Dodt G, Schneider G, Steinhilber D, Werz O: The molecular mechanism of the inhibition by licofelone of the biosynthesis of 5-lipoxygenase products. Br J Pharmacol. 2007 Oct;152(4):471-80. Epub 2007 Aug 20. |
11(0,0,0,11) | Details |
| 11698504 | Werz O, Klemm J, Radmark O, Samuelsson B: p38 MAP kinase mediates stress-induced leukotriene synthesis in a human B-lymphocyte cell line. J Leukoc Biol. 2001 Nov;70(5):830-8. Here we demonstrate that several stimuli of cell stress such as osmotic shock NaCl), oxidative stress peroxide, diamide), chemical stress sodium arsenite, and inflammatory cytokines enhanced cellular 5-LO activity in a B cell line (BL41-E95-A), when added simultaneously with ionophore plus |
11(0,0,1,6) | Details |
| 12670876 | Fischer L, Szellas D, Radmark O, Steinhilber D, Werz O: Phosphorylation- and stimulus-dependent inhibition of cellular 5-lipoxygenase activity by nonredox-type inhibitors. FASEB J. 2003 May;17(8):949-51. Epub 2003 Mar 28. |
5(0,0,0,5) | Details |
| 15519606 | Bunderson M, Brooks DM, Walker DL, Rosenfeld ME, Coffin JD, Beall HD: Arsenic exposure exacerbates atherosclerotic plaque formation and increases nitrotyrosine and leukotriene biosynthesis. Toxicol Appl Pharmacol. 2004 Nov 15;201(1):32-9. Our results reveal a significant increase in the degree of atherosclerotic plaque stenosis within the innominate artery of ApoE-/-/LDLr-/- mice treated with 10 ppm sodium arsenite (133 microM) in drinking water for 18 weeks compared to controls. In addition, there is a significant increase in the 5-lipoxygenase (5-LO) product, in the serum of arsenic-treated mice. |
2(0,0,0,2) | Details |