| Name | CYP1A1 |
|---|---|
| Synonyms | AHH; AHRR; Arylhydrocarbon hydroxylase; CP11; CYP 1; CYP1; CYP1A1; CYPIA 1… |
| Name | sodium arsenite |
|---|---|
| CAS | sodium arsenenite |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11979426 | Seubert JM, Webb CD, Bend JR: Acute sodium arsenite treatment induces Cyp2a5 but not Cyp1a1 in the C57Bl/6 mouse in a tissue (kidney) selective manner. J Biochem Mol Toxicol. 2002;16(2):96-106. Modulation of hepatic and extrahepatic detoxication enzymes Cyp1a1, Cyp2a5, S-transferse Ya (GSTYa) and NAD (P) H:quinone oxidoreductase (QOR) dependent catalytic activity and mRNA levels were investigated at 1, 2, or 4 days in liver, lung, or kidney of male, adult CD57 Bl/6 mice treated sc with a single dose (85 micromol/kg) of sodium arsenite (As3+). |
31(0,1,1,1) | Details |
| 11979425 | Seubert JM, Sinal CJ, Bend JR: Acute sodium arsenite administration induces pulmonary CYP1A1 mRNA, protein and activity in the rat. J Biochem Mol Toxicol. 2002;16(2):84-95. |
8(0,0,1,3) | Details |
| 11854143 | Spink DC, Katz BH, Hussain MM, Spink BC, Wu SJ, Liu N, Pause R, Kaminsky LS: Induction of CYP1A1 and CYP1B1 in T-47D human breast cancer cells by benzo [a] pyrene is diminished by arsenite. Drug Metab Dispos. 2002 Mar;30(3):262-9. |
7(0,0,0,7) | Details |
| 7600446 | Albores A, Sinal CJ, Cherian MG, Bend JR: Selective increase of rat lung cytochrome P450 1A1 dependent monooxygenase activity after acute sodium arsenite administration. Can J Physiol Pharmacol. 1995 Jan;73(1):153-8. |
6(0,0,1,1) | Details |
| 16274885 | Elbekai RH, El-Kadi AO: The role of oxidative stress in the modulation of aryl hydrocarbon receptor-regulated genes by As3+, Cd2+, and Cr6+. Free Radic Biol Med. 2005 Dec 1;39(11):1499-511. Epub 2005 Aug 9. In the present study, we evaluated the role of As (3+)-, Cd (2+)-, and Cr (6+)-induced oxidative stress on the expression of Cyp1a1, Nqo1, and Gst ya in Hepa 1c1c7 cells. |
4(0,0,0,4) | Details |
| 16713074 | Chao HR, Tsou TC, Li LA, Tsai FY, Wang YF, Tsai CH, Chang EE, Miao ZF, Wu CH, Lee WJ: Arsenic inhibits induction of cytochrome P450 1A1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin in human hepatoma cells. J Hazard Mater. 2006 Sep 21;137(2):716-22. Epub 2006 Apr 25. The human hepatoma Huh7 cells were treated with sodium arsenite (NaAsO2) from 0.5 to 20 microM for 24 h. |
2(0,0,0,2) | Details |
| 10329507 | Jacobs JM, Nichols CE, Andrew AS, Marek DE, Wood SG, Sinclair PR, Wrighton SA, Kostrubsky VE, Sinclair JF: Effect of arsenite on induction of CYP1A, CYP2B, and CYP3A in primary cultures of rat hepatocytes. Toxicol Appl Pharmacol. 1999 May 15;157(1):51-9. In earlier studies, sodium arsenite treatment was shown to decrease induction of enzymatic activities associated with hepatic CYPs in rats. With 3-methylcholanthrene as inducer, 5 microM arsenite caused a 55% decrease in CYP1A1 immunoreactive protein and enzyme activity, but only a 25% decrease in CYP1A1 mRNA. |
1(0,0,0,1) | Details |