| Name | phosphatidylinositol 3 kinase (protein family or complex) |
|---|---|
| Synonyms | PI3 kinase; PI3 kinases; PI3K; Phosphatidylinositol 3 kinase; Phosphatidylinositol 3 kinases; Phosphatidylinositol 4,5 bisphosphate 3 kinase; Phosphatidylinositol 4,5 bisphosphate 3 kinases |
| Name | sodium arsenite |
|---|---|
| CAS | sodium arsenenite |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12482858 | Duyndam MC, Hulscher ST, van der Wall E, Pinedo HM, Boven E: Evidence for a role of p38 kinase in hypoxia-inducible factor 1-independent induction of vascular endothelial growth factor expression by sodium arsenite. J Biol Chem. 2003 Feb 28;278(9):6885-95. Epub 2002 Dec 13. By using kinase inhibitors in OVCAR-3 cells, both effects of sodium arsenite were found to be independent of phosphatidylinositol 3-kinase and p44/p42 MAPKS but were attenuated by inhibition of p38 MAPK. |
37(0,1,2,2) | Details |
| 9299480 | Wang X, Proud CG: p70 S6 kinase is activated by sodium arsenite in adult rat cardiomyocytes: roles for phosphatidylinositol 3-kinase and p38 MAP kinase. Biochem Biophys Res Commun. 1997 Sep 8;238(1):207-12. |
32(0,1,1,2) | Details |
| 11145585 | Entingh AJ, Law BK, Moses HL: Induction of the C/EBP homologous protein (CHOP) by amino acid deprivation requires insulin-like growth factor I, phosphatidylinositol 3-kinase, and mammalian target of rapamycin signaling. Endocrinology. 2001 Jan;142(1):221-8. LY294002 and rapamycin are also able to block CHOP induction by peroxide, but do not affect expression induced by sodium arsenite or A23187. |
3(0,0,0,3) | Details |
| 12640124 | Shack S, Wang XT, Kokkonen GC, Gorospe M, Longo DL, Holbrook NJ: Caveolin-induced activation of the phosphatidylinositol 3-kinase/Akt pathway increases arsenite cytotoxicity. Mol Cell Biol. 2003 Apr;23(7):2407-14. Here we investigated the ability of caveolin-1 to modulate the cellular response to sodium arsenite and thereby alter survival of the human cell lines 293 and HeLa. |
2(0,0,0,2) | Details |
| 9873045 | Macfarlane WM, McKinnon CM, Felton-Edkins ZA, Cragg H, James RF, Docherty K: stimulates translocation of the homeodomain transcription factor PDX1 from the cytoplasm to the nucleus in pancreatic beta-cells. J Biol Chem. 1999 Jan 8;274(2):1011-6. These effects of could be mimicked by chemical stress (sodium arsenite), or by overexpression of SAPK2 in the beta-cell line MIN6. The effects of were inhibited by the SAPK2 inhibitor SB 203580, and by wortmannin and LY 294002, which inhibit phosphatidylinositol 3-kinase, although the effects of stress (arsenite) were inhibited only by SB 203580. |
1(0,0,0,1) | Details |
| 11574405 | Elrick LJ, Docherty K: Phosphorylation-dependent nucleocytoplasmic shuttling of pancreatic duodenal homeobox-1. Diabetes. 2001 Oct;50(10):2244-52. Insulin and sodium arsenite, an activator of the stress-activated pathway, also stimulated PDX-1 movement from the nuclear periphery to the nucleoplasm. and insulin regulate PDX-1 by way of a signaling pathway involving phosphatidylinositol 3-kinase (PI 3-kinase) and SAPK2/p38. |
1(0,0,0,1) | Details |