| Name | STAT3 |
|---|---|
| Synonyms | APRF; Acute phase response factor; STAT 3; STAT3; Signal transducer and activator of transcription 3; signal transducer and activator of transcription 3 (acute phase response factor); signal transducer and activator of transcription 3 isoform 1; Acute phase response factors… |
| Name | sodium arsenite |
|---|---|
| CAS | sodium arsenenite |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17070520 | Ivanov VN, Hei TK: Sodium arsenite accelerates TRAIL-mediated apoptosis in melanoma cells through upregulation of TRAIL-R1/R2 surface levels and downregulation of cFLIP expression. Exp Cell Res. 2006 Dec 10;312(20):4120-38. Epub 2006 Sep 28. Sodium arsenite is known to suppress both the IKK-NF-kappaB and JAK2-STAT3 signaling pathways and to activate the MAPK/JNK-cJun pathways, thereby committing some cancers to undergo apoptosis. |
82(1,1,1,2) | Details |
| 17689208 | Huang YC, Hung WC, Kang WY, Chen WT, Chai CY: Expression of STAT3 and Bcl-6 oncoprotein in sodium arsenite-treated SV-40 immortalized human uroepithelial cells. Toxicol Lett. 2007 Aug 30;173(1):57-65. Epub 2007 Jun 20. |
8(0,0,1,3) | Details |
| 20008137 | Kimura A, Ishida Y, Wada T, Hisaoka T, Morikawa Y, Sugaya T, Mukaida N, Kondo T: The absence of interleukin-6 enhanced arsenite-induced renal injury by promoting autophagy of tubular epithelial cells with aberrant extracellular signal-regulated kinase activation. Am J Pathol. 2010 Jan;176(1):40-50. Epub 2009 Dec 11. Sodium arsenite (NaAs)-induced autophagic cell death (ACD) of a mouse renal tubular epithelial cell line (mProx24), which expresses enhanced levels of interleukin-6 (IL-6), was reduced by the suppression of autophagy by 3-methyladenine or Atg7 knockdown. The inhibition of the IL-6/signal transducer and activator of transcription 3 (STAT3) signal pathway by anti-IL-6 antibody or a Jak2 inhibitor (AG490) exaggerated ACD of mProx24 cells after NaAs challenge, attenuating STAT3 activation and reciprocally enhancing extracellular signal-regulated kinase (ERK) phosphorylation. |
3(0,0,0,3) | Details |
| 18222423 | Ivanov VN, Partridge MA, Johnson GE, Huang SX, Zhou H, Hei TK: sensitizes melanomas to TRAIL through modulation of antiapoptotic gene expression. Exp Cell Res. 2008 Mar 10;314(5):1163-76. Epub 2007 Dec 23. One of the main contributors to TRAIL-resistance of melanoma cells is upregulation of transcription factors STAT3 and NF-kappaB that control the expression of antiapoptotic genes, including cFLIP and Bcl-xL. Interestingly, did not increase surface expression of DR5 in human melanomas, while gamma-irradiation or sodium arsenite treatment substantially upregulated DR5 expression. |
2(0,0,0,2) | Details |
| 18191166 | Ahlborn GJ, Nelson GM, Ward WO, Knapp G, Allen JW, Ouyang M, Roop BC, Chen Y, O'Brien T, Kitchin KT, Delker DA: Dose response evaluation of gene expression profiles in the skin of K6/ODC mice exposed to sodium arsenite. Toxicol Appl Pharmacol. 2008 Mar 15;227(3):400-16. Epub 2007 Nov 28. Approximately 20 genes exhibited a dose response, including several genes known to be associated with carcinogenesis or tumor progression including cyclin D1, CLIC4, Ephrin A1, STAT3 and DNA methyltransferase 3a. |
1(0,0,0,1) | Details |
| 15116095 | Cheng HY, Li P, David M, Smithgall TE, Feng L, Lieberman MW: Arsenic inhibition of the JAK-STAT pathway. Oncogene. 2004 Apr 29;23(20):3603-12. Pretreatment with sodium arsenite strongly inhibited IL-6-inducible STAT3 phosphorylation in HepG2 cells and did not affect its serine phosphorylation. |
0(0,0,0,0) | Details |
| 17224793 | Wang Q, Guo XL, Noel G, Ogle C: Heat shock stress ameliorates cytokine mixture-induced permeability by downregulating the and signal transducer and activator of transcription pathways in Caco-2 cells. Shock. 2007 Feb;27(2):179-85. A monolayer of Caco-2 cells were pretreated with sodium arsenite (SA, 500 micromol/L) for 1 h, followed by a 1-h recovery, and then stimulated with a cytokine mixture (cytomix: tumor necrosis factor alpha [10 ng/mL], interferon beta [1000 U/mL], and interleukin [IL] 1beta [1 ng/mL]) for 24 h. |
0(0,0,0,0) | Details |