| Name | HSP70s |
|---|---|
| Synonyms | APG 2; APG2; HS24/P52; HSP70RY; HSPA 4; HSPA4; Heat shock 70 kDa protein 4; Heat shock 70 related protein APG 2… |
| Name | sodium arsenite |
|---|---|
| CAS | sodium arsenenite |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 7721337 | Salotra P, Chauhan D, Ralhan R, Bhatnagar R: Tumour necrosis factor-alpha induces preferential expression of stress proteins in virulent promastigotes of Leishmania donovani. Immunol Lett. 1995 Jan;44(1):1-5. In response to stress by H2O2 or sodium arsenite, an increased expression of Hsp60 was observed in the virulent, but not avirulent, parasites. |
0(0,0,0,0) | Details |
| 10600494 | Hatayama T, Hayakawa M: Differential temperature dependency of chemical stressors in HSF1-mediated stress response in mammalian cells. Biochem Biophys Res Commun. 1999 Nov 30;265(3):763-9. Hsp70 was not induced by treatment with sodium arsenite, azetidine-2-carboxylic acid, or zinc at the level of heat shock factor (HSF) 1 activation in cells incubated at low temperature, although these treatments induced hsp70 in cells incubated at 37 degrees C. |
0(0,0,0,0) | Details |
| 15327774 | Thomson S, Hollis A, Hazzalin CA, Mahadevan LC: Distinct stimulus-specific histone modifications at hsp70 chromatin targeted by the transcription factor heat shock factor-1. Mol Cell. 2004 Aug 27;15(4):585-94. The stress-inducible gene Hsp70 is activated by heat shock or by sodium arsenite. |
84(1,1,1,4) | Details |
| 14673132 | Wadekar SA, Li D, Sanchez ER: Agonist-activated glucocorticoid receptor inhibits binding of heat shock factor 1 to the heat shock protein 70 promoter in vivo. Mol Endocrinol. 2004 Mar;18(3):500-8. Epub 2003 Dec 12. Dexamethasone inhibited HSF1 binding at the Hsp70 promoter in response to heat or chemical shock (sodium arsenite). |
35(0,1,1,5) | Details |
| 12489113 | Barnes JA, Collins BW, Dix DJ, Allen JW: Effects of heat shock protein 70 (Hsp70) on arsenite-induced genotoxicity. . Environ Mol Mutagen. 2002;40(4):236-42. |
7(0,0,0,7) | Details |
| 9820195 | Dix DJ, Garges JB, Hong RL: Inhibition of hsp70-1 and hsp70-3 expression disrupts preimplantation embryogenesis and heightens embryo sensitivity to arsenic. Mol Reprod Dev. 1998 Dec;51(4):373-80. Mouse 70-kDa heat shock proteins Hsp70-1 and Hsp70-3 (Hsp70-1/3) are stress-inducible protein chaperones thought to protect embryonic cells and tissues from the effects of a wide range of environmental exposures. Limiting expression of Hsp70-1/3 with 5 microM A070-1/3 also heightened embryo sensitivity to arsenic, resulting in less than 5% in vitro development to blastocyst in the presence of the subtoxic dose of 0.4 microM sodium arsenite. |
3(0,0,0,3) | Details |
| 9764755 | Kato K, Ito H, Kamei K, Iwamoto I: Stimulation of the stress-induced expression of stress proteins by in cultured cells and in rat tissues in vivo. Cell Stress Chaperones. 1998 Sep;3(3):152-60. a major component of a seasoning commonly used in Indian food, and a known antioxidant, anti-inflammatory and anti-carcinogenic agent, is a potent stimulator of the stress-induced expression of Hsp27, alphaB crystallin and Hsp70. |
2(0,0,0,2) | Details |
| 15033002 | Sacco MG, Amicone L, Cato EM, Filippini D, Vezzoni P, Tripodi M: Cell-based assay for the detection of chemically induced cellular stress by immortalized untransformed transgenic hepatocytes. BMC Biotechnol. 2004 Mar 19;4:5. In these cell lines, stresses induced by exposure to inorganic [Sodium Arsenite (NaAsO2) and Cadmium (CdCl2)], and organic [Benzo (a) Pyrene (BaP), PentaChloroPhenol (PCP), TetraChloroHydroQuinone (TCHQ), 1-Chloro-2,4-DiNitro- (CDNB)] compounds, specifically induced hGH release in the culture medium. We previously described transgenic mice (Hsp70/hGH) secreting high levels of human Growth Hormone (hGH) following exposure to toxic compounds in vivo and in vitro in primary cultures derived from different organs. |
2(0,0,0,2) | Details |
| 11599568 | Kimura RH, Choudary PV, Stone KK, Schmid CW: Stress induction of Bm1 RNA in silkworm larvae: SINEs, an unusual class of stress genes. Cell Stress Chaperones. 2001 Jul;6(3):263-72. Sublethal heat shock and exposure to several toxic compounds increase the level of Bm1 RNA, the silkworm SINE transcript, while also transiently increasing expression of a well-characterized stress-induced transcript, Hsp70 messenger RNA (mRNA). |
2(0,0,0,2) | Details |
| 12085988 | Lee JS, Seo JS: Differential expression of two stress-inducible hsp70 genes by various stressors. Exp Mol Med. 2002 May 31;34(2):131-6. Inducible HSP70s encoded by two almost identical hsp70 genes, known as hsp70.1 and hsp70.3 are located in a tandem array on mouse chromosome 17. L-azetidine-2-carboxylic acid, sodium arsenite, CdCl2 and ZnCI2 caused induction of both isoforms of the hsp70 genes, even though their expression levels were variable. |
2(0,0,0,2) | Details |
| 12690470 | Zhou H, Kato A, Yasuda H, Odamaki M, Itoh H, Hishida A: The induction of heat shock protein-72 attenuates cisplatin-induced acute renal failure in rats. Pflugers Arch. 2003 Apr;446(1):116-24. Epub 2003 Feb 15. The aim of this study was to clarify the effects of the induction of HSP70s on cisplatin (CDDP) (6 mg/kg i.v.)-induced ARF in rats. Uranyl (UA) or sodium arsenite (SA) were administered i.v. 14 days or 1 day respectively before CDDP injection to induce HSPs. |
1(0,0,0,1) | Details |
| 11525244 | Mark PJ, Ward BK, Kumar P, Lahooti H, Minchin RF, Ratajczak T: Human cyclophilin 40 is a heat shock protein that exhibits altered intracellular localization following heat shock. Cell Stress Chaperones. 2001 Jan;6(1):59-70. The unactivated steroid receptors are chaperoned into a conformation that is optimal for binding hormone by a number of heat shock proteins, including Hsp90, Hsp70, Hsp40, and the immunophilin, FKBP52 (Hsp56). |
1(0,0,0,1) | Details |
| 6805927 | Kothary RK, Candido EP: Induction of a novel set of polypeptides by heat shock or sodium arsenite in cultured cells of rainbow trout, Salmo gairdnerii. Can J Biochem. 1982 Mar;60(3):347-55. Hsp70 from trout comigrates with the major hsp from Drosophila melanogaster on - polyacrylamide gels, suggesting that this protein may be highly conserved in evolution. |
1(0,0,0,1) | Details |
| 11786389 | Boone AN, Ducouret B, Vijayan MM: Glucocorticoid-induced release is abolished in trout hepatocytes with elevated hsp70 content. J Endocrinol. 2002 Jan;172(1):R1-5. Exposure of hepatocytes to either heat shock (HS;+15 degrees C) or sodium arsenite (50 microM) did not affect cell viability, but resulted in significantly higher hsp70 levels over a 24 h recovery period. |
0(0,0,0,0) | Details |