| Name | polyamine oxidase |
|---|---|
| Synonyms | PAO; PAOX; Peroxisomal N1 acetyl spermine/spermidine oxidase; Polyamine oxidase; RP11 122K13.11; UNQ1923/PRO4398; polyamine oxidase (exo N4 amino); PAO… |
| Name | guazatine |
|---|---|
| CAS | guazatine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18783804 | Maiale SJ, Marina M, Sanchez DH, Pieckenstain FL, Ruiz OA: In vitro and in vivo inhibition of plant polyamine oxidase activity by polyamine analogues. Phytochemistry. 2008 Oct;69(14):2552-8. Epub 2008 Sep 8. On the contrary, with concentrations similar to those used for polyamine analogues, guazatine (a well-known fungicide and at the same time, a polyamine oxidase inhibitor) inhibited ( approximately 85%) S. sclerotiorum mycelial growth on Czapek-Dox medium. |
37(0,1,1,7) | Details |
| 12913153 | Yoda H, Yamaguchi Y, Sano H: Induction of hypersensitive cell death by peroxide produced through polyamine degradation in tobacco plants. Plant Physiol. 2003 Aug;132(4):1973-81. Polyamine oxidase activity in the apoplast increased up to 3-fold that of the basal level during the HR, and its suppression with a specific inhibitor, guazatine, resulted in reduced HR. |
31(0,1,1,1) | Details |
| 19261065 | Xue B, Zhang A, Jiang M: Involvement of polyamine oxidase in abscisic acid-induced cytosolic antioxidant defense in leaves of maize. J Integr Plant Biol. 2009 Mar;51(3):225-34. |
2(0,0,0,2) | Details |
| 15035614 | Cona A, Manetti F, Leone R, Corelli F, Tavladoraki P, Polticelli F, Botta M: Molecular basis for the binding of competitive inhibitors of maize polyamine oxidase. Biochemistry. 2004 Mar 30;43(12):3426-35. To shed light on the MPAO ligand binding mode, we studied the inhibition properties of linear diamines, prenylagmatine (G3), G3 analogues, and guazatine, and analyzed the structural determinants of their biological activity. |
2(0,0,0,2) | Details |
| 16778015 | Tavladoraki P, Rossi MN, Saccuti G, Perez-Amador MA, Polticelli F, Angelini R, Federico R: Heterologous expression and biochemical characterization of a polyamine oxidase from Arabidopsis involved in polyamine back conversion. Plant Physiol. 2006 Aug;141(4):1519-32. Epub 2006 Jun 15. The recombinant protein was purified by affinity chromatography on guazatine-Sepharose 4B and was shown to be a flavoprotein able to oxidize Spm, norspermine, and with a pH optimum at 8.0. |
2(0,0,0,2) | Details |
| 11258887 | Binda C, Angelini R, Federico R, Ascenzi P, Mattevi A: Structural bases for inhibitor binding and catalysis in polyamine oxidase. . Biochemistry. 2001 Mar 6;40(9):2766-76. To provide insight into the PAO substrate specificity and amine oxidation mechanism, we have investigated the crystal structure of maize PAO in the reduced state and in complex with three different inhibitors, guazatine, 1,8-diaminooctane, and N (1)-ethyl-N (11)-[(cycloheptyl) methyl]-4,8-diazaundecane (CHENSpm). |
2(0,0,0,2) | Details |
| 19591488 | Manetti F, Cona A, Angeli L, Mugnaini C, Raffi F, Capone C, Dreassi E, Zizzari AT, Tisi A, Federico R, Botta M: Synthesis and biological evaluation of guanidino compounds endowed with subnanomolar affinity as competitive inhibitors of maize polyamine oxidase. J Med Chem. 2009 Aug 13;52(15):4774-85. |
3(0,0,0,3) | Details |
| 11342283 | Federico R, Leone L, Botta M, Binda C, Angelini R, Venturini G, Ascenzi P: Inhibition of pig liver and Zea mays L. polyamine oxidase: a comparative study. J Enzyme Inhib. 2001;16(2):147-55. In the present study, the inhibitory effect of amiloride, p-aminobenzamidine, clonidine, 4',6-diamidino-2-phenyl- (DAPI), gabexate mesylate, guazatine, and N,N'-bis (2,3-butadienyl)-1,4-butane-diamine (MDL72527) on the catalytic activity of pig liver and Zea mays L. |
2(0,0,0,2) | Details |
| 16519678 | Bianchi M, Polticelli F, Ascenzi P, Botta M, Federico R, Mariottini P, Cona A: Inhibition of polyamine and spermine oxidases by polyamine analogues. FEBS J. 2006 Mar;273(6):1115-23. Polyamine oxidase (PAO) and spermine oxidase (SMO) are involved in the catabolism of polyamines--basic regulators of cell growth and proliferation. Here, a comparative study on murine PAO (mPAO) and SMO (mSMO) inhibition by the polyamine analogues 1,8-diaminooctane, 1,12-diaminododecane, N-prenylagmatine (G3), guazatine and N,N1-bis (2,3-butadienyl)- (MDL72527) is reported. |
1(0,0,0,1) | Details |
| 18583528 | Moschou PN, Sanmartin M, Andriopoulou AH, Rojo E, Sanchez-Serrano JJ, Roubelakis-Angelakis KA: Bridging the gap between plant and mammalian polyamine catabolism: a novel peroxisomal polyamine oxidase responsible for a full back-conversion pathway in Arabidopsis. Plant Physiol. 2008 Aug;147(4):1845-57. Epub 2008 Jun 26. Moreover, although AtPAO3 does not exhibit significant similarity to the other known PAOs, it is efficiently inhibited by guazatine, a potent PAO inhibitor. |
1(0,0,0,1) | Details |