| Name | MRP2 |
|---|---|
| Synonyms | ABC30; ABCC 2; ABCC2; ATP binding cassette sub family C member 2; CMOAT; CMOAT 1; CMOAT1; CMRP… |
| Name | sodium arsenite |
|---|---|
| CAS | sodium arsenenite |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16737587 | Gao Y, Pei QL, Li GX, Han G, Tian FJ, Qin XJ, Zhang R, Hou WS, Li XY: [Effects of MRP2-GSH cotransport system on hepatic arsenic metabolism in rats]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2006 May;24(5):278-80. CONCLUSION: Sodium arsenite can induce expression of MRP2 and the up-regulation of MRP2 may play an important role in the bile secretion of arsenite and its metabolites. |
39(0,1,1,9) | Details |
| 17324950 | Miller DS, Shaw JR, Stanton CR, Barnaby R, Karlson KH, Hamilton JW, Stanton BA: MRP2 and acquired tolerance to inorganic arsenic in the kidney of killifish (Fundulus heteroclitus). Toxicol Sci. 2007 May;97(1):103-10. Epub 2007 Feb 25. Exposure of fish to arsenic as sodium arsenite (4-14 days) increased both MRP2 expression in the apical membrane of proximal tubules and MRP2-mediated transport activity. |
34(0,1,1,4) | Details |
| 15355704 | Li GX, Pei QL, Gao Y: [Toxic effect of arsenite on the expression of liver multidrug resistance-associated protein 2 in rat]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2004 Aug;22(4):264-6. METHODS: Thirty healthy Wistar rats were divided randomly into six groups based on time of administration (2 w, 4 w, 6 w) of 20 mg/kg of sodium arsenite, and their corresponding control groups. |
6(0,0,0,6) | Details |
| 16672223 | Lee TC, Ho IC, Lu WJ, Huang JD: Enhanced expression of multidrug resistance-associated protein 2 and reduced expression of aquaglyceroporin 3 in an arsenic-resistant human cell line. J Biol Chem. 2006 Jul 7;281(27):18401-7. Epub 2006 May 3. |
5(0,0,0,5) | Details |
| 11408547 | Vernhet L, Seite MP, Allain N, Guillouzo A, Fardel O: Arsenic induces expression of the multidrug resistance-associated protein 2 (MRP2) gene in primary rat and human hepatocytes. J Pharmacol Exp Ther. 2001 Jul;298(1):234-9. Treatment of primary rat hepatocytes by sodium arsenite [As (III)], arsenate and antimony but not cadmium was shown to markedly increase MRP2 mRNA and protein levels; As (III)-mediated induction was dose- and time-dependent and paralleled a strong increase in MRP2 amounts as assessed by Western blotting. |
5(0,0,0,5) | Details |
| 14967012 | Kala SV, Kala G, Prater CI, Sartorelli AC, Lieberman MW: Formation and urinary excretion of arsenic triglutathione and methylarsenic diglutathione. Chem Res Toxicol. 2004 Feb;17(2):243-9. Following administration of sodium arsenite to these mice, approximately 60-70% of urinary arsenic is present as one of these GSH conjugates. Rodents deficient in three known ABC family transporters (MRP1, MRP2, and MDR1a/1b) exhibited urinary arsenic levels similar or greater than those in wild-type rodents; however, administration of MK571, an MRP inhibitor, reduced urinary arsenic excretion by almost 50%. |
1(0,0,0,1) | Details |