Protein Information

Name hsp90 beta
Synonyms D6S182; HSP 84; HSP 90; HSP90 BETA; HSP90AB1; HSP90B; HSPC 2; HSPC2…

Compound Information

Name sodium arsenite
CAS sodium arsenenite

Reference List

PubMed Abstract RScore(About this table)
2340977 Deaton MA, Bowman PD, Jones GP, Powanda MC: Stress protein synthesis in human keratinocytes treated with sodium arsenite, phenyldichloroarsine, and nitrogen mustard. Fundam Appl Toxicol. 1990 Apr;14(3):471-6.

Sodium arsenite induced the highest levels of synthesis of these two proteins, approximately 10-fold and 3-fold increases in hsp-70 and hsp-90, respectively.
81(1,1,1,1) Details
1312348 Edwards DP, Estes PA, Fadok VA, Bona BJ, Onate S, Nordeen SK, Welch WJ: Heat shock alters the composition of heteromeric steroid receptor complexes and enhances receptor activity in vivo. Biochemistry. 1992 Mar 10;31(9):2482-91.

Interestingly, sodium arsenite produced both a greater induction of hsp 90 and hsp 70 synthesis and a greater fold enhancement of PR-mediated gene transcription than did heat shock.
32(0,1,1,2) Details
9222590 Ali A, Krone PH, Pearson DS, Heikkila JJ: Evaluation of stress-inducible hsp90 gene expression as a potential molecular biomarker in Xenopus laevis. Cell Stress Chaperones. 1996 Apr;1(1):62-9.

The deduced amino acid sequence is 102 amino acids in length and exhibited the highest degree of identity with zebrafish and human hsp90 beta genes.
While heat shock and sodium arsenite exposure resulted in the increased accumulation of hsp90 mRNA in A6 cells, treatment with cadmium chloride and zinc chloride did not.
2(0,0,0,2) Details
12119132 Somji S, Ann Sens M, Garrett SH, Gurel V, Todd JH, Sens DA: Expression of hsp 90 in the human kidney and in proximal tubule cells exposed to heat, sodium arsenite and cadmium chloride. Toxicol Lett. 2002 Jul 21;133(2-3):241-54.
7(0,0,1,2) Details