| Name | p65 |
|---|---|
| Synonyms | Erythrocyte 65 kDa protein; p65 |
| Name | sodium arsenite |
|---|---|
| CAS | sodium arsenenite |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12241537 | Hershko DD, Robb BW, Hungness ES, Luo G, Guo X, Hasselgren PO: Arsenite inhibits interleukin-6 production in human intestinal epithelial cells by down-regulating nuclear factor-kappaB activity. Clin Sci. 2002 Oct;103(4):381-90. When cells were transfected with a plasmid expressing the p65 subunit of NF-kappaB, the inhibitory effect of sodium arsenite on NF-kappaB activity and IL-6 production was blunted. |
81(1,1,1,1) | Details |
| 19429265 | Das J, Ghosh J, Manna P, Sinha M, Sil PC: protects rat testes against NaAsO (2)-induced oxidative stress and apoptosis via mitochondrial dependent and independent pathways. Toxicol Lett. 2009 Jun 22;187(3):201-10. Epub 2009 Mar 14. Arsenite has also been shown to induce activation of mitogen-activated protein kinases (MAPKs), Akt as well as NF-kappaB (p65) in testicular tissue. |
1(0,0,0,1) | Details |
| 12676792 | Mathas S, Lietz A, Janz M, Hinz M, Jundt F, Scheidereit C, Bommert K, Dorken B: Inhibition of NF-kappaB essentially contributes to arsenic-induced apoptosis. Blood. 2003 Aug 1;102(3):1028-34. Epub 2003 Apr 3. A direct role of the NF-kappaB pathway in arsenic-induced apoptosis is shown by transient overexpression of NF-kappaB-p65 in L540Cy HRS cells, which protected the cells from arsenic-induced apoptosis. |
1(0,0,0,1) | Details |
| 19616567 | Ghosh J, Das J, Manna P, Sil PC: prevents arsenic-induced cardiac oxidative stress and apoptotic damage: role of NF-kappa B, p38 and JNK MAPK pathway. Toxicol Appl Pharmacol. 2009 Oct 1;240(1):73-87. Epub 2009 Jul 17. These changes due to arsenic exposure were found to be associated with increased IKK and NF-kappaB (p65) phosphorylation. |
1(0,0,0,1) | Details |
| 8902524 | Barchowsky A, Dudek EJ, Treadwell MD, Wetterhahn KE: Arsenic induces oxidant stress and NF-kappa B activation in cultured aortic endothelial cells. Free Radic Biol Med. 1996;21(6):783-90. Supershift analysis demonstrated that p65/p50 heterodimers accounted for the majority of proteins binding consensus kappa B sequences in cells treated with arsenite or oxidants. |
1(0,0,0,1) | Details |
| 10799907 | Yoo CG, Lee S, Lee CT, Kim YW, Han SK, Shim YS: Anti-inflammatory effect of heat shock protein induction is related to stabilization of I kappa B alpha through preventing I kappa B kinase activation in respiratory epithelial cells. J Immunol. 2000 May 15;164(10):5416-23. Both HS and sodium arsenite treatment increased HSP70 expression time dependently at mRNA and protein levels. |
0(0,0,0,0) | Details |