Protein Information

Name AQP9
Synonyms AQP 9; SSC 1; SSC1; AQP9; Aquaporin 9; HsT17287; Small solute channel 1; Aquaporin 9s…

Compound Information

Name sodium arsenite
CAS sodium arsenenite

Reference List

PubMed Abstract RScore(About this table)
19805235 Carbrey JM, Song L, Zhou Y, Yoshinaga M, Rojek A, Wang Y, Liu Y, Lujan HL, DiCarlo SE, Nielsen S, Rosen BP, Agre P, Mukhopadhyay R: Reduced arsenic clearance and increased toxicity in aquaglyceroporin-9-null mice. Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):15956-60. Epub 2009 Sep 8.


Expressed in liver, aquaglyceroporin-9 (AQP9) is permeated by glycerol, arsenite, and other small, neutral solutes.
9(0,0,0,9) Details
19341753 Shinkai Y, Sumi D, Toyama T, Kaji T, Kumagai Y: Role of aquaporin 9 in cellular accumulation of arsenic and its cytotoxicity in primary mouse hepatocytes. Toxicol Appl Pharmacol. 2009 Jun 1;237(2):232-6. Epub 2009 Mar 31.

6(0,0,0,6) Details
19733843 Torres-Avila M, Leal-Galicia P, Sanchez-Pena LC, Del Razo LM, Gonsebatt ME: Arsenite induces aquaglyceroporin 9 expression in murine livers. Environ Res. 2009 Sep 4.

Mice exposed to sodium arsenite show a dose-related accumulation of inorganic arsenic (iAs) and its methylated metabolites in the liver.
We investigated here if the dose-related accumulation of arsenic in the liver was related to the expression of aquaglyceroporin 9 (AQP9) in the same organ.
3(0,0,0,3) Details
16672223 Lee TC, Ho IC, Lu WJ, Huang JD: Enhanced expression of multidrug resistance-associated protein 2 and reduced expression of aquaglyceroporin 3 in an arsenic-resistant human cell line. J Biol Chem. 2006 Jul 7;281(27):18401-7. Epub 2006 May 3.


Little AQP7 or AQP9 mRNA was detected by reverse transcription-PCR in either cell line, whereas AQP3 mRNA expression was 2-fold lower in R15 cells than in CL3 cells.
1(0,0,0,1) Details