| Name | GADD153 |
|---|---|
| Synonyms | C/EBP homologous protein; CEBPZ; CHOP; CHOP/FUS fusion gene; CHOP10; DDIT 3; DDIT3; DNA damage inducible transcript 3… |
| Name | sodium arsenite |
|---|---|
| CAS | sodium arsenenite |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 10910055 | Simeonova PP, Wang S, Toriuma W, Kommineni V, Matheson J, Unimye N, Kayama F, Harki D, Ding M, Vallyathan V, Luster MI: Arsenic mediates cell proliferation and gene expression in the bladder epithelium: association with activating protein-1 transactivation. Cancer Res. 2000 Jul 1;60(13):3445-53. In the current studies, we demonstrate that mice exposed to 0.01% sodium arsenite in drinking water develop hyperplasia of the bladder urothelium within 4 weeks of exposure. Gene expression studies using RNase protection assays, reverse transcription-PCR, and cDNA microarrays indicated that arsenite alters the expression of a number of genes associated with cell growth, such as c-fos, c-jun, and EGR-1, as well as cell arrest, such as GADD153 and GADD45. |
1(0,0,0,1) | Details |
| 11319142 | Fontanier-Razzaq N, McEvoy TG, Robinson JJ, Rees WD: DNA damaging agents increase gadd153 (CHOP-10) messenger RNA levels in bovine preimplantation embryos cultured in vitro. Biol Reprod. 2001 May;64(5):1386-91. Treatment of bovine granulosa cell cultures with the DNA-damaging agents, methyl -sulphonate (MMS) or sodium arsenite, induced the expression of an mRNA, which hybridized with the hamster gadd153 cDNA. |
41(0,1,2,6) | Details |
| 8662954 | Fawcett TW, Eastman HB, Martindale JL, Holbrook NJ: Physical and functional association between GADD153 and CCAAT/enhancer-binding protein beta during cellular stress. J Biol Chem. 1996 Jun 14;271(24):14285-9. In this report we have demonstrated that treatment of rat pheochromocytoma PC12 cells with sodium arsenite leads to enhanced expression of C/EBP-beta and GADD153 (growth arrest and DNA damage inducible gene 153) but not other C/EBPs. |
10(0,0,0,10) | Details |
| 10542372 | Fontanier-Razzaq NC, Hay SM, Rees WD: Upregulation of CHOP-10 (gadd153) expression in the mouse blastocyst as a response to stress. Mol Reprod Dev. 1999 Dec;54(4):326-32. When mouse blastocysts were exposed to the alkylating agent MMS, the metabolic inhibitor sodium arsenite or an inhibitor of protein glycosylation tunicamycin, levels of the CHOP-10 mRNA were increased by two- to threefold relative to the mRNA for beta-actin. |
2(0,0,0,2) | Details |