| Name | HSP27 |
|---|---|
| Synonyms | DMPK binding protein; HSP27; HSPB 2; HSPB2; Heat shock 27kD protein 2; Heat shock protein beta 2; Hs.78846; MKBP… |
| Name | sodium arsenite |
|---|---|
| CAS | sodium arsenenite |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 8917706 | Wu W, Welsh MJ: Expression of the 25-kDa heat-shock protein (HSP27) correlates with resistance to the toxicity of cadmium mercuric cis-platinum (II)-diammine dichloride, or sodium arsenite in mouse embryonic stem cells transfected with sense or antisense HSP27 cDNA. Toxicol Appl Pharmacol. 1996 Nov;141(1):330-9. Compared to the parental ES cell lines or ES cells transfected with the vector lacking any HSP27 sequence, all ES cell lines overexpressing HSP27 were resistant to killing by cadmium (CdCl2), mercuric (HgCl2), cis-platinum (II)-diammine dichloride (cDDP), sodium arsenite (NaAsO2), and heat while ES cell lines expressing reduced HSP27 were more sensitive to metal toxicity and heat. |
91(1,1,2,6) | Details |
| 7541446 | Satoh J, Kim SU: Cytokines and growth factors induce HSP27 phosphorylation in human astrocytes. J Neuropathol Exp Neurol. 1995 Jul;54(4):504-12. The level of HSP27 phosphorylation was elevated greatly after a 30 minute exposure to heat shock, sodium arsenite, interleukin-1 (IL-1 alpha and IL-1 beta), and tumor necrosis factor-alpha (TNF-alpha) with an increased expression of a diphosphorylated "c" isoform. |
88(1,1,1,8) | Details |
| 11862762 | Kozawa O, Tokuda H: [Heat shock protein 27 in osteoblasts] . Nippon Yakurigaku Zasshi. 2002 Feb;119(2):89-94. Chemical stress by sodium arsenite (arsenite) induces HSP27 coupled to the metabolic activity of the cascade, and the HSP27 induction by arsenite is negatively regulated by activation of protein kinase C (PKC). |
83(1,1,1,3) | Details |
| 10841042 | Miwa M, Kozawa OO, Tokuda H, Uematsu T: Involvement of in chemical stress-induced interleukin-6 synthesis in osteoblast-like cells: comparison with heat shock protein 27 induction. Prostaglandins Leukot Essent Fatty Acids. 2000 Mar;62(3):189-93. In a previous study, we have demonstrated that sodium arsenite (arsenite) as chemical stress stimulates heat shock protein 27 (HSP27) induction and release in osteoblast-like MC3T3-E1 cells, and that the response of HSP27 induction is coupled with metabolic activity of the cascade. |
32(0,1,1,2) | Details |
| 7737136 | Huang RN, Ho IC, Yih LH, Lee TC: Sodium arsenite induces chromosome endoreduplication and inhibits protein phosphatase activity in human fibroblasts. Environ Mol Mutagen. 1995;25(3):188-96. Sodium arsenite treatment also inhibited the activities of serine/threonine protein phosphatases and enhanced phosphorylation levels of a small heat shock protein (HSP27). |
31(0,1,1,1) | Details |
| 11746514 | Tanabe K, Kozawa O, Niwa M, Yamomoto T, Matsuno H, Ito H, Kato K, Dohi S, Uematsu T: Contrasting effects of midazolam on induction of heat shock protein 27 by and heat in aortic smooth muscle cells. J Cell Biochem. 2001;84(1):39-46. In the present study, we examined the effects of midazolam, an intravenous anesthetic, on the HSP27 induction stimulated by heat, or sodium arsenite (arsenite) in A10 cells. |
13(0,0,1,8) | Details |
| 7851416 | Huot J, Lambert H, Lavoie JN, Guimond A, Houle F, Landry J: Characterization of 45-kDa/54-kDa HSP27 kinase, a stress-sensitive kinase which may activate the phosphorylation-dependent protective function of mammalian 27-kDa heat-shock protein HSP27. Eur J Biochem. 1995 Jan 15;227(1-2):416-27. The kinase activity in extracts of cells stimulated by heat shock, H2O2, sodium arsenite, TNF or growth factors was identified by in-gel renaturation and purified approximately 8000-fold by sequential chromatography. |
7(0,0,0,7) | Details |
| 1913647 | Huot J, Roy G, Lambert H, Chretien P, Landry J: Increased survival after treatments with anticancer agents of Chinese hamster cells expressing the human Mr 27,000 heat shock protein. Cancer Res. 1991 Oct 1;51(19):5245-52. A family of 10 thermoresistant cell lines cloned from Chinese hamster cells transfected with a plasmid containing the structural gene for the small human Mr 27,000 heat shock protein (HSP27) was used to assess the putative role of this heat shock protein in chemoresistance. A statistically significant increased survival relative to the parental cells was observed following treatment with daunorubicin (three clones studied), colchicine, vincristine, actinomycin D, peroxide, and sodium arsenite (one clone studied). |
6(0,0,0,6) | Details |
| 1730670 | Landry J, Lambert H, Zhou M, Lavoie JN, Hickey E, Weber LA, Anderson CW: Human HSP27 is phosphorylated at serines 78 and 82 by heat shock and mitogen-activated kinases that recognize the same amino acid motif as S6 kinase II. J Biol Chem. 1992 Jan 15;267(2):794-803. |
6(0,0,0,6) | Details |
| 17479414 | Yang P, He XQ, Peng L, Li AP, Wang XR, Zhou JW, Liu QZ: The role of oxidative stress in hormesis induced by sodium arsenite in human embryo lung fibroblast (HELF) cellular proliferation model. J Toxicol Environ Health A. 2007 Jun;70(11):976-83. Similarly, heat-shock protein 27 (HSP27) levels were increased by sodium arsenite of low concentrations with early exposure time (3, 6, and 12 h), but decreased with high metal concentrations with greater exposure time (24 and 48 h). |
6(0,0,1,1) | Details |
| 10923011 | Brophy CM, Molinaro JR, Dickinson M: The macromolecular associations of heat shock protein-27 in vascular smooth muscle. Surgery. 2000 Aug;128(2):320-6. Two small heat shock proteins, HSP27 and HSP20, have been implicated in the regulation of the contraction and relaxation of smooth muscle. |
5(0,0,0,5) | Details |
| 10664502 | Knoepp L, Beall A, Woodrum D, Mondy JS, Shaver E, Dickinson M, Brophy CM: Cellular stress inhibits vascular smooth muscle relaxation. J Vasc Surg. 2000 Feb;31(2):343-53. Recent evidence suggests that a group of small HSPs may modulate vascular smooth muscle contraction (HSP27) and/or relaxation (HSP20). |
4(0,0,0,4) | Details |
| 11740261 | Hashiguchi N, Ogura H, Tanaka H, Koh T, Nakamori Y, Noborio M, Shiozaki T, Nishino M, Kuwagata Y, Shimazu T, Sugimoto H: Enhanced expression of heat shock proteins in activated polymorphonuclear leukocytes in patients with sepsis. J Trauma. 2001 Dec;51(6):1104-9. METHODS: In blood samples from 21 patients with sepsis and serum C-reactive protein levels more than 10 mg/dL, we used flow cytometry to measure expressions of HSP27, HSP60, HSP70, and HSP90; oxidative activity; and levels of apoptosis in PMNLs during sepsis. (30 microM), a suppressor of HSP, and sodium arsenite (100 microM), an inducer of HSP, were used to regulate the expression of HSP70 in PMNLs, and oxidative activity and apoptosis in these cells were measured. |
2(0,0,0,2) | Details |
| 14676650 | Hashiguchi N, Shiozaki T, Ogura H, Tanaka H, Koh T, Noborio M, Fugita K, Akimau P, Kuwagata Y, Shimazu T, Sugimoto H: Mild hypothermia reduces expression of heat shock protein 60 in leukocytes from severely head-injured patients. J Trauma. 2003 Dec;55(6):1054-60. In in vitro studies, PMNLs from 10 healthy volunteers were incubated at 37 degrees C, 34 degrees C, or 26 degrees C for 1 hour with sodium arsenite (100 micromol/L), an HSP inducer. We measured the expression of HSP27, HSP60, HSP70, and HSP90 by flow cytometry. |
1(0,0,0,1) | Details |
| 9837746 | Kitagawa M, Mukai H, Takahashi M, Ono Y: The role of PKN in the regulation of alphaB-crystallin expression via heat shock transcription factor 1. Biochem Biophys Res Commun. 1998 Nov 27;252(3):561-5. We previously reported that PKN, a fatty acid-activated serine/threonine protein kinase, translocates from the cytosol to the nucleus by stresses such as heat shock, sodium arsenite, and serum starvation. |
0(0,0,0,0) | Details |