| Name | c Myc |
|---|---|
| Synonyms | MYC; Myc proto oncogene protein; Oncogene MYC; Transcription factor p64; c Myc; v myc avian myelocytomatosis viral oncogene homolog; v myc myelocytomatosis viral oncogene homolog (avian); Myc proto oncogene proteins… |
| Name | sodium arsenite |
|---|---|
| CAS | sodium arsenenite |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18996220 | Ruiz-Ramos R, Lopez-Carrillo L, Rios-Perez AD, De Vizcaya-Ruiz A, Cebrian ME: Sodium arsenite induces ROS generation, DNA oxidative damage, HO-1 and c-Myc proteins, NF-kappaB activation and cell proliferation in human breast cancer MCF-7 cells. Mutat Res. 2009 Mar 31;674(1-2):109-15. Epub 2008 Oct 18. Therefore, our aim was to further explore the ability of sodium arsenite to induce MCF-7 epithelial breast cell proliferation and some of its underlying mechanisms by studying ROS production, c-Myc and HO-1 protein levels, formation and NF-kappaB activation. |
88(1,1,2,3) | Details |
| 19766132 | Ruiz-Ramos R, Lopez-Carrillo L, Albores A, Hernandez-Ramirez RU, Cebrian ME: Sodium arsenite alters cell cycle and MTHFR, MT1/2, and c-Myc protein levels in MCF-7 cells. Toxicol Appl Pharmacol. 2009 Dec 15;241(3):269-74. Epub 2009 Sep 17. |
15(0,0,2,5) | Details |
| 11559025 | Chen H, Liu J, Zhao CQ, Diwan BA, Merrick BA, Waalkes MP: Association of c-myc overexpression and hyperproliferation with arsenite-induced malignant transformation. Toxicol Appl Pharmacol. 2001 Sep 15;175(3):260-8. |
9(0,0,0,9) | Details |
| 9219559 | Germolec DR, Spalding J, Boorman GA, Wilmer JL, Yoshida T, Simeonova PP, Bruccoleri A, Kayama F, Gaido K, Tennant R, Burleson F, Dong W, Lang RW, Luster MI: Arsenic can mediate skin neoplasia by chronic stimulation of keratinocyte-derived growth factors. Mutat Res. 1997 Jun;386(3):209-18. Total cell numbers, as well as c-myc expression and incorporation of [3H] both indicators of cell proliferation, were also elevated in keratinocyte cultures treated with sodium arsenite. |
6(0,0,1,1) | Details |
| 8917704 | Germolec DR, Yoshida T, Gaido K, Wilmer JL, Simeonova PP, Kayama F, Burleson F, Dong W, Lange RW, Luster MI: Arsenic induces overexpression of growth factors in human keratinocytes. . Toxicol Appl Pharmacol. 1996 Nov;141(1):308-18. Treatment with sodium arsenite resulted in a significant increase in cell proliferation, as indicated by increases in cell numbers, c-myc gene expression, and incorporation of [3H] thymidine into cellular DNA. |
6(0,0,1,1) | Details |
| 9848127 | Shimizu M, Hochadel JF, Fulmer BA, Waalkes MP: Effect of depletion and metallothionein gene expression on arsenic-induced cytotoxicity and c-myc expression in vitro. Toxicol Sci. 1998 Oct;45(2):204-11. |
5(0,0,0,5) | Details |
| 14691202 | Liu J, Xie Y, Ward JM, Diwan BA, Waalkes MP: Toxicogenomic analysis of aberrant gene expression in liver tumors and nontumorous livers of adult mice exposed in utero to inorganic arsenic. Toxicol Sci. 2004 Feb;77(2):249-57. Epub 2003 Dec 22. Liver tumors and nontumorous liver samples were taken at necropsy from adult male mice exposed in utero to either 42.5 or 85 ppm arsenic as sodium arsenite or unaltered water from day 8 to 18 of gestation. Overexpression of alpha-fetoprotein, c-myc, cyclin D1, proliferation-associated protein PAG, and cytokeratin-18 were more dramatic in arsenic-induced HCC than spontaneous tumors. |
2(0,0,0,2) | Details |
| 10764629 | Trouba KJ, Wauson EM, Vorce RL: Sodium arsenite-induced dysregulation of proteins involved in proliferative signaling. Toxicol Appl Pharmacol. 2000 Apr 15;164(2):161-70. Analysis of positive proliferative regulators revealed an increase in the expression of c-myc and E2F-1, thereby supporting the hypothesis that arsenic increases activity of positive growth modulators. |
1(0,0,0,1) | Details |
| 12115494 | Takahashi M, Barrett JC, Tsutsui T: Transformation by inorganic arsenic compounds of normal Syrian hamster embryo cells into a neoplastic state in which they become anchorage-independent and cause tumors in newborn hamsters. Int J Cancer. 2002 Jun 10;99(5):629-34. Amplification of the c-myc or c-Ha-ras oncogene was detected in 3 of 5 and 4 of 5 tumorigenic cell lines, respectively. In order to investigate the ability of inorganic arsenics to transform normal cells into a neoplastic state, mass cultures of normal, diploid Syrian hamster embryo (SHE) cells exposed to various concentrations of sodium arsenite or arsenate for 48 hr were continually passaged and tested for neoplastic transformation, as determined by anchorage-independent growth in semisolid agar and tumorigenicity in newborn hamsters. |
1(0,0,0,1) | Details |
| 9511760 | Lu TH, Lambrecht RW, Pepe J, Shan Y, Kim T, Bonkovsky HL: Molecular cloning, characterization, and expression of the chicken heme oxygenase-1 gene in transfected primary cultures of chick embryo liver cells. Gene. 1998 Jan 30;207(2):177-86. These include AP-1, AP-2, NF-kB, C/EBP, c-Myc and a metal-responding element identified in the promoter region, and two Sp-1 elements in intron 1. Transient expression studies in transfected primary cultures of chick embryo liver cells showed that a CAT reporter gene construct containing 2.8 kb of the cHO-1 promoter region responded to sodium arsenite, H2O2, transition metals and 12-0-tetradecanoylphorbol 13- but not to heme. |
1(0,0,0,1) | Details |
| 18037969 | Wen G, Calaf GM, Partridge MA, Echiburu-Chau C, Zhao Y, Huang S, Chai Y, Li B, Hu B, Hei TK: Neoplastic transformation of human small airway epithelial cells induced by arsenic. Mol Med. 2008 Jan-Feb;14(1-2):2-10. Human small airway epithelial cells (SAECs) previously immortalized with human telomerase reverse transcriptase (h-TERT) were continuously treated with sodium arsenite at a dose of 0.5 microg/mL in culture for up to 6 months. In addition, arsenic-treated cells showed an increase in c-H-ras, c-myc, and c-fos protein expression relative to controls. |
1(0,0,0,1) | Details |