| Name | IkappaBalpha |
|---|---|
| Synonyms | I kappa B alpha; Mad3; IKB alpha; IKBA; IKBalpha; IkappaBalpha; Inhibitor of kappa light chain gene enhancer in B cells alpha; MAD 3… |
| Name | sodium arsenite |
|---|---|
| CAS | sodium arsenenite |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11835394 | Hershko DD, Robb BW, Hungness ES, Luo G, Hasselgren PO: Arsenite stabilizes IkappaBalpha and prevents NF-kappaB activation in IL-1 beta-stimulated Caco-2 cells independent of the heat shock response. J Cell Biochem. 2002;84(4):687-98. Recent studies suggest that sodium arsenite downregulates NF-kappaB activity by inhibiting phosphorylation and subsequent degradation of IkappaBalpha. |
89(1,1,2,4) | Details |
| 15611262 | Pittet JF, Lee H, Pespeni M, O'Mahony A, Roux J, Welch WJ: Stress-induced inhibition of the NF-kappaB signaling pathway results from the insolubilization of the IkappaB kinase complex following its dissociation from heat shock protein 90. J Immunol. 2005 Jan 1;174(1):384-94. In this study, we show that the activation of the cellular stress response, either by heat shock treatment or after exposure to sodium arsenite, leads to a transient inhibition of IkappaBalpha phosphorylation. |
83(1,1,1,3) | Details |
| 16243048 | Sun D, Chen D, Du B, Pan J: Heat shock response inhibits NF-kappaB activation and cytokine production in murine Kupffer cells. J Surg Res. 2005 Nov;129(1):114-21. MATERIALS AND METHODS: Kupffer cells were isolated from mice by collagenase digestion and HSP was induced by culturing Kupffer cells with sodium arsenite. Heat shock protein (HSP)-70 expression and cytoplasmic IkappaBalpha protein was determined by Western blot. |
5(0,0,0,5) | Details |
| 10799907 | Yoo CG, Lee S, Lee CT, Kim YW, Han SK, Shim YS: Anti-inflammatory effect of heat shock protein induction is related to stabilization of I kappa B alpha through preventing I kappa B kinase activation in respiratory epithelial cells. J Immunol. 2000 May 15;164(10):5416-23. Both HS and sodium arsenite treatment increased HSP70 expression time dependently at mRNA and protein levels. |
4(0,0,0,4) | Details |
| 10896383 | Pritts TA, Wang Q, Sun X, Moon MR, Fischer DR, Fischer JE, Wong HR, Hasselgren PO: Induction of the stress response in vivo decreases nuclear factor-kappa B activity in jejunal mucosa of endotoxemic mice. Arch Surg. 2000 Jul;135(7):860-6. The increase in NF-kappa B DNA binding activity and decrease in I kappa B-alpha levels seen after endotoxin injection were inhibited by previous induction of the stress response. METHODS: The stress response was induced in mice by hyperthermia (42 degrees C) or injection with sodium arsenite (10 mg/kg). |
1(0,0,0,1) | Details |
| 17941083 | Bhagat L, Singh VP, Dawra RK, Saluja AK: Sodium arsenite induces heat shock protein 70 expression and protects against secretagogue-induced trypsinogen and NF-kappaB activation. J Cell Physiol. 2008 Apr;215(1):37-46. |
0(0,0,0,0) | Details |
| 10521501 | Jaspers I, Samet JM, Reed W: Arsenite exposure of cultured airway epithelial cells activates kappaB-dependent interleukin-8 gene expression in the absence of nuclear factor-kappaB nuclear translocation. J Biol Chem. 1999 Oct 22;274(43):31025-33. We compared intracellular signaling mediating IL-8 gene expression in bronchial epithelial cells cultured in vitro and exposed to two inducers of cellular stress, sodium arsenite (As (III)), and vanadyl (V (IV)). Accordingly, V (IV) induced IkappaBalpha breakdown and NF-kappaB nuclear translocation, whereas As (III) did not. |
1(0,0,0,1) | Details |
| 9751585 | DeMeester SL, Qiu Y, Buchman TG, Hotchkiss RS, Dunnigan K, Karl IE, Cobb JP: inhibits stress-induced endothelial cell apoptosis. Crit Care Med. 1998 Sep;26(9):1500-9. The ability of these agents to alter the rate of cell death by apoptosis (induced by the sequence stimuli lipopolysaccharide [LPS] followed by sodium arsenite) was measured. Mechanistic studies included examining the ability of: a) "donors" to alter nuclear factor kappa B (NF-kappaB) DNA binding activity and the level of IkappaBalpha accumulation; and b) a stable cyclic analog (8-bromo- to mimic the effect of donors. |
1(0,0,0,1) | Details |
| 16160914 | Chen D, Pan J, Du B, Sun D: Induction of the heat shock response in vivo inhibits NF-kappaB activity and protects murine liver from endotoxemia-induced injury. J Clin Immunol. 2005 Sep;25(5):452-61. We report here on the effects of the heat shock response (HSR) induced by sodium arsenite on endotoxemia-induced liver injury as well as hepatic NF-kappaB activation and proinflammatory cytokine expression. Prior induction of HSR significantly attenuated endotoxemia-induced histological changes, inhibited hepatic NF-kappaB activation and IkappaBalpha degradation and decreased mortality. |
1(0,0,0,1) | Details |