| Name | stress activated protein kinase 2 |
|---|---|
| Synonyms | MAP kinase 11; MAP kinase p38 beta; MAPK11; Mitogen activated protein kinase 11; Mitogen activated protein kinase p38 beta; P38B; P38BETA2… |
| Name | sodium arsenite |
|---|---|
| CAS | sodium arsenenite |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9877156 | McDowell HE, Eyers PA, Hundal HS: Regulation of System A amino acid transport in L6 rat skeletal muscle cells by insulin, chemical and hyperthermic stress. FEBS Lett. 1998 Dec 11;441(1):15-9. Uptake of alpha-methyl-aminoisobutyric acid (Me-AIB), a non-metabolisable System A substrate, was increased by between 50% and 80% when muscle cells were exposed to a maximally effective concentration of insulin (100 nM), sodium arsenite (ARS, 0.5 mM) or a 42 degrees C heat shock (HS). |
0(0,0,0,0) | Details |
| 9288946 | Thomas G, Haavik J, Cohen P: Participation of a stress-activated protein kinase cascade in the activation of tyrosine hydroxylase in chromaffin cells. Eur J Biochem. 1997 Aug 1;247(3):1180-9. Sodium arsenite and osmotic shock both stimulated stress-activated protein kinase-2 (SAPK2, also termed RK, p38, CSBP and Mxi2) and its downstream target mitogen-activated protein kinase (MAP kinase)-activated protein kinase-2 (MAPKAP-K2) in bovine chromaffin and rat PC12 cells. |
34(0,1,1,4) | Details |
| 9873045 | Macfarlane WM, McKinnon CM, Felton-Edkins ZA, Cragg H, James RF, Docherty K: stimulates translocation of the homeodomain transcription factor PDX1 from the cytoplasm to the nucleus in pancreatic beta-cells. J Biol Chem. 1999 Jan 8;274(2):1011-6. These effects of could be mimicked by chemical stress (sodium arsenite), or by overexpression of SAPK2 in the beta-cell line MIN6. |
10(0,0,1,5) | Details |
| 15362974 | McNeill H, Knebel A, Arthur JS, Cuenda A, Cohen P: A novel UBA and UBX domain protein that binds polyubiquitin and VCP and is a substrate for SAPKs. Biochem J. 2004 Dec 1;384(Pt 2):391-400. Termed SAKS1 (SAPK substrate-1), it was phosphorylated efficiently at Ser200 in vitro by SAPK3/p38gamma, SAPK4/p38delta and JNK (c-Jun N-terminal kinase), but weakly by SAPK2a/p38alpha, SAPK2b/p38beta2 or ERK (extracellular-signal-regulated kinase) 2. |
1(0,0,0,1) | Details |
| 9712902 | Cheong J, Coligan JE, Shuman JD: Activating transcription factor-2 regulates phosphoenolpyruvate carboxykinase transcription through a stress-inducible mitogen-activated protein kinase pathway. J Biol Chem. 1998 Aug 28;273(35):22714-8. We demonstrate that p38beta mitogen-activated protein (MAP) kinase augments ATF-2 transactivation activity on the PEPCK-C promoter, which is consistent with the interpretation that PEPCK-C promoter activity is maintained under stress through a p38 MAP kinase dependent pathway. In this regard, we show that treatment with sodium arsenite, a known activator of p38 MAP kinases, also stimulates expression from the PEPCK promoter. |
1(0,0,0,1) | Details |
| 10590320 | Fladeby C, Serck-Hanssen G: Stress-induced uptake in bovine chromaffin cells: a comparison of the effect of arsenite and anisomycin. Biochim Biophys Acta. 1999 Dec 9;1452(3):313-21. The selective inhibitor of stress-activated protein kinase 2 (SAPK2), SB 203580, inhibited completely anisomycin-induced uptake but only partly suppressed uptake stimulated by arsenite. |
3(0,0,0,3) | Details |
| 11574405 | Elrick LJ, Docherty K: Phosphorylation-dependent nucleocytoplasmic shuttling of pancreatic duodenal homeobox-1. Diabetes. 2001 Oct;50(10):2244-52. Insulin and sodium arsenite, an activator of the stress-activated pathway, also stimulated PDX-1 movement from the nuclear periphery to the nucleoplasm. and insulin regulate PDX-1 by way of a signaling pathway involving phosphatidylinositol 3-kinase (PI 3-kinase) and SAPK2/p38. |
2(0,0,0,2) | Details |