Protein Information

Name lactate dehydrogenase (protein family or complex)
Synonyms LDH; lactate dehydrogenase; lactate dehydrogenases

Compound Information

Name alachlor
CAS

Reference List

PubMed Abstract RScore(About this table)
20120471 Tilak KS, Raju PW, Butchiram MS: Effects of alachlor on biochemical parameters of the freshwater fish, Channa punctatus (Bloch). J Environ Biol. 2009 May;30(3):420-6.

The fresh water fish Channa punctatus (Bloch) were exposed to lethal and sublethal concentrations of a chloroacetanilide herbicide Alachlor and its commercial formulation Lasso 50% Emulsifiable Concentrate EC to study the impacts on some biochemical parameters - the energy dependent sources: such as glycogen, total proteins and metabolic enzymes: Aspartate amino transferase (AAT), Alanine amino transferase (ALAT), Lactate Dehydrogenase (LDH), Deoxyribonucleic acid (DNA) and Ribonucleic acid (RNA).
7(0,0,1,2) Details
17207564 Miranda SR, Meyer SA: Cytotoxicity of chloroacetanilide herbicide alachlor in HepG2 cells independent of CYP3A4 and CYP3A7. Food Chem Toxicol. 2007 May;45(5):871-7. Epub 2006 Nov 26.

Here, we report time-dependent alachlor cytotoxicity (EC (50) approximately 500 microM and 264+/-17 microM at 6 and 24h, respectively) as assessed by lactate dehydrogenase leakage.
6(0,0,1,1) Details
8560491 Bagchi D, Bagchi M, Hassoun EA, Stohs SJ: In vitro and in vivo generation of reactive oxygen species, DNA damage and lactate dehydrogenase leakage by selected pesticides. Toxicology. 1995 Dec 15;104(1-3):129-40.

Reactive oxygen species may be involved in the toxicity of various pesticides and we have, therefore, examined the in vivo effects of structurally dissimilar polyhalogenated cyclic hydrocarbons (PCH), such as endrin and chlordane, chlorinated acetamide herbicides (CAH), such as alachlor, and organophosphate pesticides (OPS), such as chlorpyrifos and fenthion, on the production of hepatic and brain lipid peroxidation and DNA-single strand breaks (SSB), two indices of oxidative stress and oxidative tissue damage.
3(0,0,0,3) Details
16998629 Fernandez M, Rios JC, Jos A, Repetto G: Comparative cytotoxicity of alachlor on RTG-2 trout and SH-SY5Y human cells. Arch Environ Contam Toxicol. 2006 Nov;51(4):515-20. Epub 2006 Sep 5.

After 24 h, cytoplasmic membrane integrity by cytosolic lactate dehydrogenase (LDH) leakage and LDH intracellular activity were also studied.
1(0,0,0,1) Details