Protein Information

Name MC1
Synonyms ATP7A; MK; ATPase; Cation transporting ATPase; ATP7A protein; ATPase Cu(2+) transporting alpha polypeptide; Copper pump 1; Copper transporting ATPase 1…

Compound Information

Name dichlorprop
CAS 2-(2,4-dichlorophenoxy)propanoic acid

Reference List

PubMed Abstract RScore(About this table)
11572451 Muller RH, Kleinsteuber S, Babel W: Physiological and genetic characteristics of two bacterial strains utilizing phenoxypropionate and phenoxyacetate herbicides. Microbiol Res. 2001;156(2):121-31.

Strain MC1 has about threefold higher activities for the degradation of dichlorprop and for growth on this substrate (mumax = 0.15 h (-1)) than strain P230; the maximum growth rate on 2,4-D amounts to 0.045 h (-1) with strain MC1.
89(1,1,2,4) Details
15345421 Schleinitz KM, Kleinsteuber S, Vallaeys T, Babel W: Localization and characterization of two novel genes encoding stereospecific dioxygenases catalyzing 2 (2,4-dichlorophenoxy) propionate cleavage in Delftia acidovorans MC1. Appl Environ Microbiol. 2004 Sep;70(9):5357-65.

Two novel genes, rdpA and sdpA, encoding the enantiospecific alpha-ketoglutarate dependent dioxygenases catalyzing R,S-dichlorprop cleavage in Delftia acidovorans MC1 were identified.
82(1,1,1,2) Details
9642189 Zipper C, Bunk M, Zehnder AJ, Kohler HP: Enantioselective uptake and degradation of the chiral herbicide dichlorprop [(RS)-2-(2,4-dichlorophenoxy) propanoic acid] by Sphingomonas herbicidovorans MH. J Bacteriol. 1998 Jul;180(13):3368-74.

Transport of (R)-dichlorprop, (S)-dichlorprop, and 2,4-D was completely inhibited by various uncouplers and by nigericin but was only marginally inhibited by valinomycin and by the ATPase inhibitor N,N'-dicyclohexylcarbodiimine.
31(0,1,1,1) Details
20305027 Paulin MM, Nicolaisen MH, Sorensen J: Abundance and expression of enantioselective rdpA and sdpA dioxygenase genes during degradation of the racemic herbicide (R,S)-dichlorprop in soil. Appl Environ Microbiol. 2010 Mar 19.

Expression of rdpA and sdpA in Delftia acidovorans MC1 inoculated in soil was monitored by reverse-transcription quantitative real-time PCR (qPCR) during in situ degradation of 2 and 50 mg kg (-1) of (R,S)-dichlorprop. (R,S)-dichlorprop amendment created a clear up-regulation of both rdpA and sdpA gene expression during the active phase of (14) C-labeled (R,S)-dichlorprop mineralization, particularly following the second dose of 50 mg kg (-1) herbicide.
31(0,1,1,1) Details
16715405 Hoffmann D, Muller RH: 2,4-Dichlorophenoxyacetic acid (2,4-D) utilization by Delftia acidovorans MC1 at alkaline pH and in the presence of dichlorprop is improved by introduction of the tfdK gene. Biodegradation. 2006 Jun;17(3):263-73.
9(0,0,1,4) Details
12501996 Westendorf A, Benndorf D, Muller RH, Babel W: The two enantiospecific dichlorprop/alpha-ketoglutarate-dioxygenases from Delftia acidovorans MC1--protein and sequence data of RdpA and SdpA. Microbiol Res. 2002;157(4):317-22.
7(0,0,1,2) Details
10652787 Muller RH, Jorks S, Kleinsteuber S, Babel W: Comamonas acidovorans strain MC1: a new isolate capable of degrading the chiral herbicides dichlorprop and mecoprop and the herbicides 2,4-D and MCPA. Microbiol Res. 1999 Dec;154(3):241-6.
6(0,0,1,1) Details
15056896 Muller RH, Babel W: Delftia acidovorans MC1 resists high herbicide concentrations--a study of nutristat growth on (RS)-2-(2,4-Dichlorophenoxy) propionate and 2,4-dichlorophenoxyacetate. Biosci Biotechnol Biochem. 2004 Mar;68(3):622-30.

2(0,0,0,2) Details
15466552 Muller TA, Byrde SM, Werlen C, van der Meer JR, Kohler HP: Genetic analysis of phenoxyalkanoic acid degradation in Sphingomonas herbicidovorans MH. Appl Environ Microbiol. 2004 Oct;70(10):6066-75.


No coherent pattern was derived on the possible origin of the sdp, rdp, and dcc pathway genes. rdpA (MH) was 99% identical to rdpA (MC1), an (R)-dichlorprop/alpha-ketoglutarate dioxygenase from Delftia acidovorans MC1, which is evidence for a recent gene exchange between Alpha- and Betaproteobacteria.
0(0,0,0,0) Details