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Richards RG, Brown OE, Sedwick WD: Misincorporation of deoxyuridine in human cells: consequences of antifolate exposure. Basic Life Sci. 1985;31:149-62.
Treatment of B and T lymphoblastoid cell lines (SB and MOLT-4, respectively) and a promyelocytic leukemia cell line (HL-60) with the lipid soluble antifolate, 2,4-diamino-5-methyl-6-(2',5'-dimeth-oxybenzyl) -pyrido (2,4-d) pyrimidine (BW301U), led to drug dose-dependent inhibition of [3H] deoxyuridine (dU) incorporation into DNA as thymidine, and to misincorporation of [3H] dU as dUMP. |
31(0,1,1,1) |
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