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De Moliner KL, Evangelista de Duffard AM, Soto E, Duffard R, Adamo AM: Induction of apoptosis in cerebellar granule cells by 2,4-dichlorophenoxyacetic acid. Neurochem Res. 2002 Nov;27(11):1439-46.
Treatment of CGC with 2,4-D appears to induce apoptosis by a direct effect on mitochondria producing cytochrome c release and consequently activation of caspase-3, being mitochondrial damage sufficient for triggering the events that may cause apoptosis. |
82(1,1,1,2) |
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Kaioumova D, Susal C, Opelz G: Induction of apoptosis in human lymphocytes by the herbicide 2,4-dichlorophenoxyacetic acid. Hum Immunol. 2001 Jan;62(1):64-74.
While an inhibitor of caspase-9, as well as caspase-9 and caspase-3 inhibitors in combination, strongly blocked DMA-2,4-D-induced apoptosis, an inhibitor of caspase-3 had a moderate inhibitory effect. |
81(1,1,1,1) |
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