Protein Information

Name tyrosine hydroxylase
Synonyms Putative tyrosine hydroxylase variant; TH; TH protein; TYH; Truncated tyrosine hydroxylase; Tyrosine 3 hydroxylase; Tyrosine 3 monooxygenase; Tyrosine hydroxylase…

Compound Information

Name 2,4-D
CAS 2-(2,4-dichlorophenoxy)acetic acid

Reference List

PubMed Abstract RScore(About this table)
16931444 Garcia GB, Konjuh C, Duffard RO, Evangelista de Duffard AM: Dopamine-beta-hydroxylase immunohistochemical study in the locus coeruleus of neonate rats exposed to 2,4-dichlorophenoxyacetic acid through mother's milk. Drug Chem Toxicol. 2006;29(4):435-42.

As tyrosine hydroxylase levels in the LC are regulated by serotonin and in a previous study we demonstrated that this neurotransmitter was increased in 2,4-D-exposed pups, an indirect effect through serotonergic inhibition could be involved in the decreased DbetaH synthesis in the LC of these pups.
31(0,1,1,1) Details
15474613 Garcia G, Tagliaferro P, Ferri A, Evangelista de Duffard AM, Duffard R, Brusco A: Study of tyrosine hydroxylase immunoreactive neurons in neonate rats lactationally exposed to 2,4-dichlorophenoxyacetic Acid. Neurotoxicology. 2004 Dec;25(6):951-7.

Dopaminergic neurons from the midbrain nuclei substantia nigra (SN; A9) and ventral tegmental area (VTA; A10) were investigated by tyrosine hydroxylase (TH) immunostaining in neonate rat brains exposed to 2,4-dichlorophenoxyacetic acid (2,4-D) through lactation.
7(0,0,1,2) Details