Protein Information

Name alanine aminotransferase
Synonyms AAT1; AAT1; GPT; ALT 1; ALT1; Alanine aminotransferase; Alanine aminotransferase 1; GPT 1…

Compound Information

Name 2,4-D
CAS 2-(2,4-dichlorophenoxy)acetic acid

Reference List

PubMed Abstract RScore(About this table)
1726651 Paulino CA, Palermo-Neto J: Effects of acute 2,4-dichlorophenoxyacetic acid intoxication on some rat serum components and enzyme activities. Braz J Med Biol Res. 1991;24(2):195-8.

The present study was undertaken to investigate the effects of acute 2,4-dichlorophenoxyacetic acid (2,4-D) intoxication (0.6 g/kg, po) on lactate dehydrogenase, alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, amylase, creatinine, glucose, total protein and albumin levels in rats.
12(0,0,2,2) Details
8540221 Paulino CA, Palermo-Neto J: Effects of acute 2,4-dichlorophenoxyacetic acid on cattle serum components and enzyme activities. Vet Hum Toxicol. 1995 Aug;37(4):329-32.

The acute toxicity of 2,4-dichlorophenoxyacetic acid (2,4-D) was studied in cattle.
Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (AP), O-glutamyl transferase (O-GT), creatine kinase (CK), lactate dehydrogenase (LDH) activities and urea, creatinine, glucose, total proteins and albumin levels were determined at intervals after dosing.
1(0,0,0,1) Details
9928676 Charles JM, Leeming NM: Chronic dietary toxicity study on 2,4-dichlorophenoxybutyric acid in the dog. Toxicol Sci. 1998 Nov;46(1):134-42.


Treatment-related findings included reductions in body weight gain and food consumption, and minor increases in inorganic phosphorus, blood urea nitrogen, creatinine, aspartate aminotransferase, and alanine aminotransferase.
1(0,0,0,1) Details
8888538 Paulino CA, Guerra JL, Oliveira GH, Palermo-Neto J: Acute, subchronic and chronic 2,4-dichlorophenoxyacetic acid (2,4-D) intoxication in rats. Vet Hum Toxicol. 1996 Oct;38(5):348-52.

After acute exposure, the herbicide decreased locomotor activity and induced ataxia, sedation, muscular weakness (mainly of the hind quarters) and gasping for breath; increased aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), alkaline phosphatase (AP), amylase activities and creatinine levels; decreased total protein (TP) and glucose levels; and increased hematocrit values.
1(0,0,0,1) Details
9565231 Morgulis MS, Oliveira GH, Dagli ML, Palermo-Neto J: Acute 2,4-dichlorophenoxyacetic acid intoxication in broiler chicks. Poult Sci. 1998 Apr;77(4):509-15.


The acute toxicity of 2,4-dichlorophenoxyacetic acid (2,4-D), a herbicide, was studied in chicks dosed with 100, 300, 500, or 600 mg 2,4-D/kg BW, by the oral route.
0(0,0,0,0) Details
8838642 Charles JM, Dalgard DW, Cunny HC, Wilson RD, Bus JS: Comparative subchronic and chronic dietary toxicity studies on 2,4-dichlorophenoxyacetic acid, amine, and ester in the dog. Fundam Appl Toxicol. 1996 Jan;29(1):78-85.

Forms of 2,4-dichlorophenoxyacetic acid (2,4-D) are herbicides used in the control of a wide variety of broadleaf and woody plants.
Treatment related findings in the three studies included reductions in body weight gain, and food consumption, and minor increases in blood urea nitrogen, creatinine, and alanine aminotransferase.
1(0,0,0,1) Details