Protein Information

Name MCAD
Synonyms CDH 3; MCAD; CDH3; Cadherin 3; CDH14; CDH15; CDHM; Cadherin 14…

Compound Information

Name MCPA
CAS 2-(4-chloro-2-methylphenoxy)acetic acid

Reference List

PubMed Abstract RScore(About this table)
9804184 Broadway NM, Engel PC: Novel methylenecyclopropyl-based acyl-CoA dehydrogenase inhibitor. . FEBS Lett. 1998 Oct 16;437(1-2):122-6.

The hexyl-substituent on the methylenecyclopropyl ring gave an inhibitor which rapidly inactivated MCAD and LCAD whilst VLCAD was inhibited more slowly and SCAD was essentially unaffected.
SCAD and MCPA-CoA) inhibition was accompanied by flavin bleaching.
1(0,0,0,1) Details
1931995 Tserng KY, Jin SJ, Hoppel CL: Spiropentaneacetic acid as a specific inhibitor of medium-chain acyl-CoA dehydrogenase. Biochemistry. 1991 Nov 5;30(44):10755-60.

In contrast, MCPA inhibited both MCAD and short-chain acyl-CoA dehydrogenase with a stronger inhibition toward the latter.
82(1,1,1,2) Details