Protein Information

Name glutathione reductase
Synonyms GLUR; GR; GRD 1; GRD1; GRase; GSR; Glutathione reductase; GRases…

Compound Information

Name MCPA
CAS 2-(4-chloro-2-methylphenoxy)acetic acid

Reference List

PubMed Abstract RScore(About this table)
3969683 Hietanen E, Ahotupa M, Heinonen T, Hamalainen H, Kunnas T, Linnainmaa K, Mantyla E, Vainio H: Enhanced peroxisomal beta-oxidation of fatty acids and glutathione metabolism in rats exposed to phenoxyacetic acids. Toxicology. 1985 Feb;34(2):103-11.

Glutathione reductase activity increased by about 40% after administration of either 2,4-D or MCPA, and glutathione peroxidase activity increased by 30% in animals given MCPA.
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9580876 Holovska K, Lenartova V, Rosival I, Kicinkova M, Majerciakova A, Legath J: Antioxidant and detoxifying enzymes in the liver and kidney of pheasants after intoxication by herbicides MCPA and ANITEN I. J Biochem Mol Toxicol. 1998;12(4):235-44.

The activity of antioxidant and detoxifying enzymes, such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSHPx), glutathione reductase, glutathione-S-transferase (GST), the contents of thiobarbituric acid reactive substances, and the superoxide dismutase and glutathione-S-transferase isoenzyme patterns, were determined in the liver and kidney of pheasants after acute intoxication by herbicides MCPA and ANITEN I.
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