Protein Information

Name MCADH
Synonyms ACAD 1; ACAD1; ACADM; MCAD; MCADH; medium chain acyl coenzyme A dehydrogenase; medium chain acyl CoA dehydrogenase; medium chain acyl coenzyme A dehydrogenases…

Compound Information

Name MCPA
CAS 2-(4-chloro-2-methylphenoxy)acetic acid

Reference List

PubMed Abstract RScore(About this table)
2331485 Ikeda Y, Tanaka K: Selective inactivation of various acyl-CoA dehydrogenases by (methylenecyclopropyl) acetyl-CoA. Biochim Biophys Acta. 1990 Apr 19;1038(2):216-21.

Short-chain acyl-CoA (SCADH), medium-chain acyl-CoA (MCADH) and isovaleryl-CoA (IVDH) dehydrogenases were severely and irreversibly inactivated by MCPA-CoA, while 2-methyl-branched chain acyl-CoA dehydrogenase (2-meBCADH) was only slowly and mildly inactivated.
163(2,2,2,3) Details
1931995 Tserng KY, Jin SJ, Hoppel CL: Spiropentaneacetic acid as a specific inhibitor of medium-chain acyl-CoA dehydrogenase. Biochemistry. 1991 Nov 5;30(44):10755-60.

However, only methylenecyclopropaneacetic acid (MCPA) and spiropentaneacetic acid (SPA) showed in vivo inhibitory activity in rats as indicated by the occurrence of dicarboxylic aciduria.
2(0,0,0,2) Details