| Name | cytochrome P450 (protein family or complex) |
|---|---|
| Synonyms | cytochrome P450; cytochrome P 450; CYP450; CYP 450 |
| Name | MCPA |
|---|---|
| CAS | 2-(4-chloro-2-methylphenoxy)acetic acid |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 1807004 | Inomata N, Yoshida H, Aoki Y, Tsunoda M, Yamamoto M: Effects of MCPA and other phenoxyacid compounds on hepatic xenobiotic metabolism in rats. Tohoku J Exp Med. 1991 Nov;165(3):171-82. Clofibrate also increased the activities of hepatic microsomal cytochrome P-450-mediated oxidation tested, but to a lesser extent when compared with the effects of MCPA. |
37(0,1,2,2) | Details |
| 6624478 | Hietanen E, Linnainmaa K, Vainio H: Effects of phenoxyherbicides and on the hepatic and intestinal biotransformation activities in the rat. Acta Pharmacol Toxicol. 1983 Aug;53(2):103-12. The effects of phenoxyacid herbicides 2,4-D (2,4-dichlorophenoxyacetic acid) and MCPA (4-chloro-2-methylphenoxyacetic acid), clofibrate, and on hepatic and intestinal drug metabolizing enzyme activities were studied in rats intragastrically exposed for 2 weeks. decreased the hepatic level of cytochrome P-450 and monooxygenase activities and the intestinal activity of aryl hydrocarbon hydroxylase. |
1(0,0,0,1) | Details |
| 9839397 | Camatini M, Bonfanti P, Colombo A, Urani C: Molecular approaches to evaluate pollutants. Chemosphere. 1998 Dec;37(14-15):2717-38. Moreover we present some significative results obtained by the use of cultured cell lines to test the herbicide MCPA. The results obtained demonstrate that the amphibian Xenopus is a suitable indicator for induction of cytochrome P-450 by B [a] P as well as for production of DNA adducts. |
1(0,0,0,1) | Details |