Protein Information

Name albumin
Synonyms ALB; Albumin; PRO0883; PRO0903; PRO1341; PRO1708; PRO2044; PRO2619…

Compound Information

Name MCPA
CAS 2-(4-chloro-2-methylphenoxy)acetic acid

Reference List

PubMed Abstract RScore(About this table)
2778260 Braunlich H, Bernhardt H, Bernhardt I: Renal handling of 2-methyl-4-chlorophenoxyacetic acid (MCPA) in rats. J Appl Toxicol. 1989 Aug;9(4):255-8.

Accumulation of MCPA under anaerobic conditions indicates an additional passive uptake and binding of MCPA in kidney tissue in accordance with the high degree of binding to plasma albumin (85%).
81(1,1,1,1) Details
2904874 Elo HA, Hervonen H, Ylitalo P: Comparative study on cerebrovascular injuries by three chlorophenoxyacetic acids (2,4-D, 2,4,5-T and MCPA). Comp Biochem Physiol C. 1988;90(1):65-8.

At toxic doses in rats, 2,4-dichlorophenoxyacetic acid (2,4-D) and 2-methyl-4-chlorophenoxyacetic acid (MCPA) caused injuries in blood vessels in the brain. 2. 2,4-D caused extravasations of the circulating Evans blue-albumin complex also in the spinal cord. 3.
31(0,1,1,1) Details
6978592 Elo HA, Ylitalo P, Kyottila J, Hervonen H: Increase in the penetration of tracer compounds into the rat brain during 2-methyl-4-chlorophenoxyacetic acid (MCPA) intoxication. Acta Pharmacol Toxicol. 1982 Feb;50(2):104-7.

The penetration of different intravenous tracer molecules such as 14C-labelled 2-methyl-4-chlorophenoxyacetic acid (14C-MCPA), 14C-p-aminobenzoic acid (14C-PABA), 14C-sucrose, 14C-antipyrine and iodinated (125I) human albumin (125I-HA) into the brain and cerebrospinal fluid (CSF) was studied in MCPA-intoxicated and control rats.
6(0,0,1,1) Details
6741574 Porsti I, Ylitalo P: Penetration of some compounds through blood-brain and blood-testis barriers in chronically hypertensive rats. Acta Physiol Scand. 1984 Mar;120(3):387-91.

In chronic hypertension after 14C-MCPA and 14C-sucrose administration the penetration of radioactivity into the brain, cerebrospinal fluid and testis had significantly decreased or showed evidence of decrease, while after 14C-antipyrine administration the penetration remained unchanged.
Penetration of Evans blue-albumin complex into the brain was studied by giving intravenous injection of Evans blue (5% solution) which is firmly bound to serum albumin.
1(0,0,0,1) Details