Protein Information

Name protoporphyrinogen oxidase
Synonyms Mutant protoporphyrinogen oxidase; VP; PPO; PPOX; Protoporphyrinogen oxidase; V290M; Protoporphyrinogen oxidases

Compound Information

Name lactofen
CAS 2-ethoxy-1-methyl-2-oxoethyl 5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrobenzoate

Reference List

PubMed Abstract RScore(About this table)
16299178 Graham MY: The diphenylether herbicide lactofen induces cell death and expression of defense-related genes in soybean. Plant Physiol. 2005 Dec;139(4):1784-94. Epub 2005 Nov 18.

Lactofen belongs to the diphenylether class of herbicides, which targets protoporphyrinogen oxidase, which in turn causes singlet oxygen generation.
81(1,1,1,1) Details
16894159 Patzoldt WL, Hager AG, McCormick JS, Tranel PJ: A codon deletion confers resistance to herbicides inhibiting protoporphyrinogen oxidase. Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12329-34. Epub 2006 Aug 7.

One gene from the resistant biotype, designated PPX2L, contained a codon deletion that was shown to confer resistance by complementation of a hemG mutant strain of Escherichia coli grown in the presence and absence of the PPO inhibitor lactofen.
2(0,0,0,2) Details