Protein Information

Name myoglobin
Synonyms MB; Myoglobin; PVALB; Myoglobins

Compound Information

Name borax
CAS borax

Reference List

PubMed Abstract RScore(About this table)
15652203 Coviello T, Grassi M, Palleschi A, Bocchinfuso G, Coluzzi G, Banishoeib F, Alhaique F: A new scleroglucan/borax hydrogel: swelling and drug release studies. Int J Pharm. 2005 Jan 31;289(1-2):97-107. Epub 2004 Dec 25.

B12) and Myoglobin (MGB)) from the gel and from the dried system used as a matrix for tablets was studied.
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19694483 Frasconi M, Rea S, Matricardi P, Favero G, Mazzei F: Scleroglucan-borax hydrogel: a flexible tool for redox protein immobilization. Langmuir. 2009 Sep 15;25(18):11097-104.

Heme proteins, such as hemoglobin (Hb), myoglobin (Mb), and horseradish peroxidase (HRP), were chosen as model proteins to investigate the immobilized system.
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16554128 Matricardi P, Onorati I, Coviello T, Alhaique F: Drug delivery matrices based on scleroglucan/alginate/borax gels. Int J Pharm. 2006 Jun 19;316(1-2):21-8. Epub 2006 Mar 6.

In this work, description is given of the in vitro ability of the matrix to deliver in a controlled manner a protein, Myoglobin, in distilled water, simulated gastric fluid and simulated intestinal fluid; the release, simulating a gastric passage, followed by an enteric delivery, was also carried out.
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12957304 Coviello T, Coluzzi G, Palleschi A, Grassi M, Santucci E, Alhaique F: Structural and rheological characterization of Scleroglucan/borax hydrogel for drug delivery. Int J Biol Macromol. 2003 Sep;32(3-5):83-92.

The obtained hydrogel was loaded with three different model molecules (Theophylline, Vitamin B12 and Myoglobin) and then, after freeze-drying, was used as a matrix for tablets.
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