Protein Information

Name CA1
Synonyms CA IX; CA1; Carbonic anhydrase I; CA2; CAII; Carbonic anhydrase II; Carbonic dehydratase; Carbonic anhydrase III…

Compound Information

Name ferrous sulfate
CAS sulfuric acid iron(2+) salt (1:1)

Reference List

PubMed Abstract RScore(About this table)
9705946 Wen TC, Tanaka J, Peng H, Desaki J, Matsuda S, Maeda N, Fujita H, Sato K, Sakanaka M: Interleukin 3 prevents delayed neuronal death in the hippocampal CA1 field. J Exp Med. 1998 Aug 17;188(4):635-49.

7(0,0,0,7) Details
10553945 Masino SA, Mesches MH, Bickford PC, Dunwiddie TV: Acute peroxide treatment of rat hippocampal slices induces adenosine-mediated inhibition of excitatory transmission in area CA1. Neurosci Lett. 1999 Oct 22;274(2):91-4.

Simultaneous addition of hydrogen peroxide (0.01%) and ferrous sulfate (100 microM) resulted in a > 80% decrease in synaptic potentials recorded in the CA1 region of hippocampal slices of adult male rats.
7(0,0,1,2) Details
9231752 Wilde GJ, Pringle AK, Wright P, Iannotti F: Differential vulnerability of the CA1 and CA3 subfields of the hippocampus to superoxide and hydroxyl radicals in vitro. J Neurochem. 1997 Aug;69(2):883-6.

5(0,0,0,5) Details
9538899 Peng H, Wen TC, Tanaka J, Maeda N, Matsuda S, Desaki J, Sudo S, Zhang B, Sakanaka M: Epidermal growth factor protects neuronal cells in vivo and in vitro against transient forebrain ischemia- and free radical-induced injuries. J Cereb Blood Flow Metab. 1998 Apr;18(4):349-60.


In the present in vivo study using a gerbil ischemia-model, we examined the effects of EGF on ischemia-induced learning disability and hippocampal CA1 neuron damage.
3(0,0,0,3) Details
3437974 Pellmar TC: Peroxide alters neuronal excitability in the CA1 region of guinea-pig hippocampus in vitro. Neuroscience. 1987 Nov;23(2):447-56.

2(0,0,0,2) Details
10436036 Ko GY, Kelly PT: Nitric oxide acts as a postsynaptic signaling molecule in calcium/calmodulin-induced synaptic potentiation in hippocampal CA1 pyramidal neurons. J Neurosci. 1999 Aug 15;19(16):6784-94.

In contrast, extracellular perfusion of membrane-impermeable NO scavengers N-methyl-D-glucamine dithiocarbamate/ferrous sulfate mixture (MGD-Fe) or 2-(4-carboxyphenyl)-4,4,5, 5-tetramethylimidazoline-1-oxyl-3-oxide (carboxy-PTIO) did not attenuate Ca (2+)/CaM-induced synaptic potentiation, even though MGD-Fe or carboxy-PTIO blocked tetanus-induced synaptic potentiation.
2(0,0,0,2) Details
9527626 Sudo S, Wen TC, Desaki J, Matsuda S, Tanaka J, Arai T, Maeda N, Sakanaka M: Beta-estradiol protects hippocampal CA1 neurons against transient forebrain ischemia in gerbil. Neurosci Res. 1997 Dec;29(4):345-54.

2(0,0,0,2) Details
18684804 Chao HM, Chen YH, Liu JH, Lee SM, Lee FL, Chang Y, Yeh PH, Pan WH, Chi CW, Liu TY, Lui WY, Ho LT, Kuo CD, Lin DE, Chan CC, Yang DM, Lin AM, Chao FP: Iron-generated hydroxyl radicals kill retinal cells in vivo: effect of ferulic acid. Hum Exp Toxicol. 2008 Apr;27(4):327-39.


Siderosis also resulted in an excessive glutamate release, increased [Ca (++)](i), and enhanced superoxide dismutase immunoreactivity.
1(0,0,0,1) Details