| Name | aconitase |
|---|---|
| Synonyms | ACO 2; Aconitase; Citrate hydro lyase; ACO2; ACO2 protein; ACONM; Aconitase 2; Citrate hydrolyase aconitase… |
| Name | ferrous sulfate |
|---|---|
| CAS | sulfuric acid iron(2+) salt (1:1) |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16841252 | Murakami K, Haneda M, Yoshino M: Prooxidant action of and quinoline compounds: role of transition metals in the generation of reactive oxygen species and enhanced formation of 8-hydroxy-2'-deoxyguanosine in DNA. Biometals. 2006 Aug;19(4):429-35. Aconitase, the most sensitive enzyme to oxidative stress was inactivated effectively by and to a lesser extent by 8-quinolinol in the presence of ferrous sulfate. |
32(0,1,1,2) | Details |
| 17316945 | Murakami K, Haneda M, Makino T, Yoshino M: Prooxidant action of furanone compounds: implication of reactive oxygen species in the metal-dependent strand breaks and the formation of 8-hydroxy-2'-deoxyguanosine in DNA. Food Chem Toxicol. 2007 Jul;45(7):1258-62. Epub 2007 Jan 18. Only 2.5-furanone known as a "strawberry or pineapple furanone" inactivated aconitase the most sensitive enzyme to active in the presence of ferrous sulfate, suggesting the furaneol/iron-mediated generation of reactive species. 2,5-Furanone caused strand scission of pBR322 DNA in the presence of |
32(0,1,1,2) | Details |
| 9466826 | Cheung PY, Danial H, Jong J, Schulz R: Thiols protect the inhibition of myocardial aconitase by . Arch Biochem Biophys. 1998 Feb 1;350(1):104-8. |
4(0,0,0,4) | Details |
| 10419470 | Brazzolotto X, Gaillard J, Pantopoulos K, Hentze MW, Moulis JM: Human cytoplasmic aconitase (Iron regulatory protein 1) is converted into its [3Fe-4S] form by peroxide in vitro but is not activated for iron-responsive element binding. J Biol Chem. 1999 Jul 30;274(31):21625-30. IRP1 is a cytoplasmic aconitase when it contains a [4Fe-4S] cluster and an RNA-binding protein after complete removal of the metal center by an unknown mechanism. Ferrous sulfate (but not other more tightly coordinated ferrous ions, such as the complex with ethylenediamine tetraacetic acid) counteracts the inhibitory action of peroxide on cytoplasmic aconitase, probably by replenishing iron at the active site. |
3(0,0,0,3) | Details |
| 16364055 | Murakami K, Ohara Y, Haneda M, Tsubouchi R, Yoshino M: Prooxidant action of hinokitiol: hinokitiol-iron dependent generation of reactive species. Basic Clin Pharmacol Toxicol. 2005 Dec;97(6):392-4. The inactivation of aconitase was iron-dependent, and prevented by TEMPOL, a scavenger of reactive species and superoxide dismutase, suggesting that the hinokitiol/iron-mediated generation of is responsible for the inactivation of aconitase. |
2(0,0,0,2) | Details |