Protein Information

Name C4S
Synonyms Acidic C4; Acidic complement C4; C4; C4A; C4A2; C4A3; C4A4; C4A6…

Compound Information

Name ferrous sulfate
CAS sulfuric acid iron(2+) salt (1:1)

Reference List

PubMed Abstract RScore(About this table)
17879260 Campo GM, Avenoso A, Campo S, D'Ascola A, Traina P, Sama D, Calatroni A: NF-kB and caspases are involved in the hyaluronan and chondroitin-4-sulphate-exerted antioxidant effect in fibroblast cultures exposed to oxidative stress. J Appl Toxicol. 2008 May;28(4):509-17.


It was previously reported that hyaluronan (HA) and chondroitin-4-sulphate (C4S) were able to protect human skin fibroblasts from oxidative stress.
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15346651 Campo GM, Avenoso A, Campo S, D'Ascola A, Ferlazzo AM, Calatroni A: Reduction of DNA fragmentation and hydroxyl radical production by hyaluronic acid and chondroitin-4-sulphate in iron plus ascorbate-induced oxidative stress in fibroblast cultures. Free Radic Res. 2004 Jun;38(6):601-11.


Since several reports have shown that hyaluronic acid (HYA) and chondroitin-4-sulphate (C4S) are able to inhibit lipid peroxidation during oxidative stress, We investigated the antioxidant capacity of these GAGs in reducing oxidative damage in fibroblast cultures.
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