Protein Information

Name ATPase
Synonyms ATP7A; MK; ATPase; Cation transporting ATPase; ATP7A protein; ATPase Cu(2+) transporting alpha polypeptide; Copper pump 1; Copper transporting ATPase 1…

Compound Information

Name ferrous sulfate
CAS sulfuric acid iron(2+) salt (1:1)

Reference List

PubMed Abstract RScore(About this table)
8394084 Rohn TT, Hinds TR, Vincenzi FF: Ion transport ATPases as targets for free radical damage. Biochem Pharmacol. 1993 Aug 3;46(3):525-34.

Preincubation of red blood cell membranes in the presence of ferrous sulfate and EDTA resulted in both a concentration- and time-dependent inhibition of the Na+/K+ pump ATPase, basal Ca2+ pump ATPase, and the calmodulin- (CaM) activated Ca2+ pump ATPase.
82(1,1,1,2) Details
7494543 Shao Q, Matsubara T, Bhatt SK, Dhalla NS: Inhibition of cardiac sarcolemma Na (+)-K+ ATPase by oxyradical generating systems. Mol Cell Biochem. 1995 Jun 7-21;147(1-2):139-44.

7(0,0,0,7) Details
11406113 Souza-Santos P, Ramos RS, Ferreira ST, Carvalho-Alves PC: Iron-induced oxidative damage of corn root plasma membrane H (+)-ATPase. . Biochim Biophys Acta. 2001 Jun 6;1512(2):357-66.

7(0,0,0,7) Details
8080446 Wei N, Sadrzadeh SM: Enhancement of hemin-induced membrane damage by artemisinin. Biochem Pharmacol. 1994 Aug 17;48(4):737-41.


We used erythrocyte membrane-bound Ca2+ pump ATPase (basal) and calmodulin (CaM)-activated Ca2+ pump ATPase as our model.
6(0,0,0,6) Details
2931083 Promkhatkaew D, Komaratat P, Wilairat P: Ascorbic acid-Fe2+ treatment mimics effect of vitamin E deficiency on sarcoplasmic Ca-ATPase of rabbit muscle. Biochem Int. 1985 Jun;10(6):937-43.

4(0,0,0,4) Details
10914467 Tomeckova V, Barnova E, Guzy J, Chavkova Z, Marekova M, Dubayova K, Kusnir J: [Fe2+-induced oxidative processes in the liver mitochondria of rats] . Bratisl Lek Listy. 2000;101(4):213-8.


The activity of ATPase was insignificantly raised to 105%, whereas the superoxide dismutase activity has decreased significantly to 77%.
2(0,0,0,2) Details
8619892 Rohn TT, Hinds TR, Vincenzi FF: Inhibition of Ca2+-pump ATPase and the Na+/K+-pump ATPase by iron-generated free radicals. Biochem Pharmacol. 1996 Feb 23;51(4):471-6.

Preincubation of red blood cell (RBC) membranes with a model system known to generate reactive oxygen species (ROS) and free radicals (200 microM ferrous sulfate and 200 microM EDTA, Fe2+/EDTA) resulted inhibition of the Na+/K+ -pump ATPases was also associated with membrane protein crosslinking and lipid peroxidation, the latter as monitored by the formation of thiobarbituric acid reactive substances (TBARS).
2(0,0,0,2) Details
10905541 Agil A, Sadrzadeh SM: Hydroxy-urea protects erythrocytes against oxidative damage. Redox Rep. 2000;5(1):29-34.

In addition, OH-U blocked t-BHP-mediated changes in membrane ATPase activities.
Intact RBCs or RBC membranes were exposed to t-butyl hydroperoxide (t-BHP, 0.75 mM) or iron (ferrous sulfate; 100 microM) at 37 degrees C for 60 min in the presence or absence of OH-U (1.25 mM).
1(0,0,0,1) Details
1646970 Oldfield FF, Cowan DL, Sun AY: The involvement of ethanol in the free radical reaction of 6-hydroxydopamine. Neurochem Res. 1991 Jan;16(1):83-7.


The amount of hydroxyethyl free radicals in the system was dependent upon the concentration of ethanol and the formation of hydroxyethyl free radicals correlated well with the extent of lipid peroxidation and the loss of enzymic activity of the membrane-bound (Na+,K+)-ATPase.
1(0,0,0,1) Details
12916070 Thirunavukkarasu V, Anuradha CV, Viswanathan P: Protective effect of fenugreek (Trigonella foenum graecum) seeds in experimental ethanol toxicity. Phytother Res. 2003 Aug;17(7):737-43.


Activity of Ca (2+) ATPase in brain was significantly lowered.
1(0,0,0,1) Details