Protein Information

Name ferroxidase
Synonyms CP; CP protein; Ceruloplasmin; Ceruloplasmin precursor; Ferroxidase; ceruloplasmin (ferroxidase); CP; CP proteins…

Compound Information

Name ferrous sulfate
CAS sulfuric acid iron(2+) salt (1:1)

Reference List

PubMed Abstract RScore(About this table)
15752568 Babizhayev MA, Semiletov YA, Lul'kin YA, Sakina NL, Savel'yeva EL, Alimbarova LM, Barinskii IP: 3D molecular modeling, free radical modulating and immune cells signaling activities of the novel peptidomimetic L-glutamyl-histamine: possible immunostimulating role. Peptides. 2005 Apr;26(4):551-63. Epub 2004 Dec 29.

L-Glu-Hist accelerated the decrease of ferrous iron in the ferrous sulfate solution in a concentration-dependent mode and showed the ferroxidase-like activity at concentrations less than 3 mM in the phenanthroline assay, whereas in the concentration range 3-20 mM L-Glu-Hist restricted the availability of Fe2+ to phenanthroline due to binding of ferrous ions in chelating complexes.
32(0,1,1,2) Details
10381611 Babizhayev MA, Semiletov YA, Lul'kin YA, Sakina NL, Savel'yeva EL, Deyev AI, Alimbarova LI, Barinskii IF, Nicolay J, Paillet C, Langrand G, Seguin F: Cellular signalling and free-radical modulating activities of the novel peptidomimetic L-glutamyl-histamine. Biochemistry. 1999 May;64(5):510-22.

L-Glu-Hist concentration-dependently accelerates a decrease in ferrous iron in ferrous sulfate solution and shows ferroxidase-like activity at concentrations less than 3 mM in the phenanthroline assay, whereas in the concentration range 3-20 mM it restricts the availability of Fe2+ to phenanthroline by chelation of iron ions.
32(0,1,1,2) Details
1536576 de Silva D, Miller DM, Reif DW, Aust SD: In vitro loading of apoferritin. Arch Biochem Biophys. 1992 Mar;293(2):409-15.


This study compared the effect of loading apoferritin either with ferrous ammonium sulfate in various buffers or with ceruloplasmin and chelated ferrous iron.
4(0,0,0,4) Details
3759957 Bakker GR, Boyer RF: Iron incorporation into apoferritin. J Biol Chem. 1986 Oct 5;261(28):13182-5.


The role of apoferritin as a ferroxidase..
4(0,0,0,4) Details
10413229 Vitoratos N, Salamalekis E, Dalamaga N, Kassanos D, Creatsas G: Defective antioxidant mechanisms via changes in serum ceruloplasmin and total iron binding capacity of serum in women with pre-eclampsia. Eur J Obstet Gynecol Reprod Biol. 1999 May;84(1):63-7.

3(0,0,0,3) Details
12667611 Lindsay S, Brosnahan D, Lowery TJ Jr, Crawford K, Watt GD: Kinetic studies of iron deposition in horse spleen ferritin using O2 as oxidant. Biochim Biophys Acta. 2003 Apr 7;1621(1):57-66.


An optical flow cell provided a means to conveniently measure the rate of successive Fe (2+) oxidation reactions catalyzed by horse spleen ferritin (HoSF) to determine if both ferroxidase and mineral core Fe (2+) oxidation reactions occur.
2(0,0,0,2) Details
6405558 Kirchgessner M, Kim JJ, Grassmann E: [Cu and Fe content and ceruloplasmin and catalase activities in the blood of growing rats receiving different amounts of Fe and Cu] Zentralbl Veterinarmed A. 1983 Jan;30(1):15-25.

1(0,0,0,1) Details
12907830 Sozmen EY, Kavakli K, Cetinkaya B, Akcay YD, Yilmaz D, Aydinok Y: Effects of iron (II) salts and iron (III) complexes on trace element status in children with iron-deficiency anemia. Biol Trace Elem Res. 2003 Jul;94(1):79-86.

Fourteen of them were treated with ferric hydroxide-polymaltose complex (Ferrum, Vifor, Switzerland) (6 mg/d in the first 3 mo for initial therapy and 3 mg/kg for 3 mo as maintenance); the others were treated with a ferrous sulfate complex (FerroSanol, Schwarz, Germany) (6 mg/d in the first 3 mo for initial therapy and 3 mg/kg for 3 mo as maintenance).
Plasma copper, zinc, and ceruloplasmin levels as well as hematological parameters were determined at baseline and the first, third, and sixth month of the treatment period.
3(0,0,0,3) Details
8182785 Morais MB, Fisberg M, Suzuki HU, Amancio OM, Machado NL: Effects of oral iron therapy on serum copper and serum ceruloplasmin in children. J Trop Pediatr. 1994 Feb;40(1):51-2.

1(0,0,0,1) Details
2912000 Yadrick MK, Kenney MA, Winterfeldt EA: Iron, copper, and zinc status: response to supplementation with zinc or zinc and iron in adult females. Am J Clin Nutr. 1989 Jan;49(1):145-50.


Group Z received 50 mg Zn/d as Zn gluconate; group F-Z received 50 mg Fe as ferrous sulfate monohydrate in addition to the Zn.
0(0,0,0,0) Details