| Name | Iron regulatory protein 1 |
|---|---|
| Synonyms | ACO 1; ACO1; Aconitase; Aconitase 1; Aconitase 1 variant; Aconitate hydratase; Citrate hydro lyase; Ferritin repressor protein… |
| Name | ferrous sulfate |
|---|---|
| CAS | sulfuric acid iron(2+) salt (1:1) |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 10419470 | Brazzolotto X, Gaillard J, Pantopoulos K, Hentze MW, Moulis JM: Human cytoplasmic aconitase (Iron regulatory protein 1) is converted into its [3Fe-4S] form by peroxide in vitro but is not activated for iron-responsive element binding. J Biol Chem. 1999 Jul 30;274(31):21625-30. Iron regulatory protein 1 (IRP1) regulates the synthesis of proteins involved in iron homeostasis by binding to iron-responsive elements (IREs) of messenger RNA. Ferrous sulfate (but not other more tightly coordinated ferrous ions, such as the complex with ethylenediamine tetraacetic acid) counteracts the inhibitory action of peroxide on cytoplasmic aconitase, probably by replenishing iron at the active site. |
5(0,0,0,5) | Details |
| 4090766 | Szczodrak J, Ilczuk Z: Effect of iron on the activity of aconitate hydratase and synthesis of by Aspergillus niger. Zentralbl Mikrobiol. 1985;140(7):567-74. |
3(0,0,0,3) | Details |
| 19342511 | Khomenko T, Szabo S, Deng X, Ishikawa H, Anderson GJ, McLaren GD: Role of iron in the pathogenesis of -induced duodenal ulceration in rats. Am J Physiol Gastrointest Liver Physiol. 2009 Jun;296(6):G1277-86. Epub 2009 Apr 2. also enhanced activation of mucosal iron regulatory protein 1 and increased the expression of divalent metal transporter 1 mRNA and protein. |
1(0,0,0,1) | Details |