| Name | ferritin (protein family or complex) |
|---|---|
| Synonyms | Ferritin; Ferritins |
| Name | ferrous sulfate |
|---|---|
| CAS | sulfuric acid iron(2+) salt (1:1) |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16920866 | Hicks PD, Zavaleta N, Chen Z, Abrams SA, Lonnerdal B: Iron deficiency, but not anemia, upregulates iron absorption in breast-fed peruvian infants. J Nutr. 2006 Sep;136(9):2435-8. We studied 2 groups of human milk-fed infants using (57) Fe (given as ferrous sulfate without any milk) and (58) Fe (given at the time of a breast-milk feeding) stable isotopes to determine whether healthy infants at risk for iron deficiency would regulate their iron absorption based on their iron status. Following log transformation, iron absorption from (57) Fe (r = -0.61, P = < 0.001) and (58) Fe (r = -0.61, P = < 0.001) were inversely correlated to serum ferritin (S-Ft). |
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| 8468108 | Liguori L: protein succinylate in the treatment of iron deficiency: controlled, double-blind, multicenter clinical trial on over 1,000 patients. Int J Clin Pharmacol Ther Toxicol. 1993 Mar;31(3):103-23. Although in the first month the reference treatment appears to provide somewhat faster results, at the end of the observation, the values of hematocrit, hemoglobin and ferritin were greater in the ITF 282 group, indicating a more progressive and steady therapeutic effect. |
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| 19740974 | Zimmermann MB, Troesch B, Biebinger R, Egli I, Zeder C, Hurrell RF: Plasma hepcidin is a modest predictor of dietary iron bioavailability in humans, whereas oral iron loading, measured by stable-isotope appearance curves, increases plasma hepcidin. Am J Clin Nutr. 2009 Nov;90(5):1280-7. Epub 2009 Sep 9. DESIGN: In the first study, young women (n = 98) with an iron status varying from iron deficiency anemia to iron sufficiency (women with serum ferritin concentrations 25-40 microg/L were not included) were given stable isotope-labeled test meals (n = 196) containing ferrous sulfate, ferrous or ferric after which plasma hepcidin and iron bioavailability were measured. RESULTS: In study 1, plasma hepcidin and plasma ferritin were strongly correlated (r = 0.79, P < 0.001). |
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| 3810831 | Gordeuk VR, Brittenham GM, Hughes MA, Keating LJ: for short-term supplementation in female blood donors. Transfusion. 1987 Jan-Feb;27(1):80-5. In those treated with ferrous sulfate (n = 17) the mean TIBC increased (p less than 0.001), and in the placebo group (n = 19) there were decreases in mean MCV (p less than 0.01), serum ferritin (p less than 0.001), and percent saturation (p = 0.027) with an increase in mean TIBC (p = 0.004). |
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| 15811774 | Chang YJ, Jo MY, Hwang EH, Park CU, Kim KS: Recovery from iron deficiency in rats by the intake of recombinant yeast producing human H-ferritin. Nutrition. 2005 Apr;21(4):520-4. |
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| 8221666 | Cermak J, Balla J, Jacob HS, Balla G, Enright H, Nath K, Vercellotti GM: Tumor cell heme uptake induces ferritin synthesis resulting in altered oxidant sensitivity: possible role in chemotherapy efficacy. Cancer Res. 1993 Nov 1;53(21):5308-13. |
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| 18054688 | Konofal E, Lecendreux M, Deron J, Marchand M, Cortese S, Zaim M, Mouren MC, Arnulf I: Effects of iron supplementation on attention deficit hyperactivity disorder in children. Pediatr Neurol. 2008 Jan;38(1):20-6. Twenty-three nonanemic children (aged 5-8 years) with serum ferritin levels <30 ng/mL who met DSM-IV criteria for ADHD were randomized (3:1 ratio) to either oral iron (ferrous sulfate, 80 mg/day, n = 18) or placebo (n = 5) for 12 weeks. |
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| 14522736 | Cogswell ME, Parvanta I, Ickes L, Yip R, Brittenham GM: supplementation during pregnancy, anemia, and birth weight: a randomized controlled trial. Am J Clin Nutr. 2003 Oct;78(4):773-81. Of these, 275 had a hemoglobin concentration >/= 110 g/L and a ferritin concentration >/= 20 micro g/L and were randomly assigned to receive a monthly supply of capsules containing either 30 mg Fe as ferrous sulfate or placebo until 28 wk of gestation. |
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| 7774536 | Hallberg L, Hulthen L, Bengtsson C, Lapidus L, Lindstedt G: balance in menstruating women. Eur J Clin Nutr. 1995 Mar;49(3):200-7. OBJECTIVES: To study factors determining iron balance in menstruating women by examining the relationships between total iron requirements, based on menstrual iron losses and basal iron losses, and serum ferritin concentration, transferrin saturation, blood haemoglobin concentration, bone marrow haemosiderin and absorption of iron from a test dose of ferrous sulphate (0.56 mg Fe). |
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| 18408148 | King SM, Donangelo CM, Knutson MD, Walter PB, Ames BN, Viteri FE, King JC: Daily supplementation with iron increases lipid peroxidation in young women with low iron stores. Exp Biol Med. 2008 Jun;233(6):701-7. Epub 2008 Apr 11. The aim of this study was to determine whether women with low iron stores (plasma ferritin Twelve women participated in the study for a 70-day period and consumed daily iron supplements (98 mg of iron as ferrous sulfate) from day 14 to day 70. |
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| 9756115 | Bhandari S, Brownjohn A, Turney J: Effective utilization of erythropoietin with intravenous iron therapy. J Clin Pharm Ther. 1998 Feb;23(1):73-8. All patients had a serum ferritin (SF) of < or = 60 microg/L, despite oral iron therapy. |
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| 12362799 | Dutra-de-Oliveira JE, de Almeida CA: Domestic drinking water--an effective way to prevent anemia among low socioeconomic families in Brazil. Food Nutr Bull. 2002 Sep;23(3 Suppl):213-6. Blood samples were collected, before and after the four months, for hemoglobin and serum ferritin measurements. |
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| 2485578 | Olivares M, Walter T, Hertrampf E, Pizarro F, Stekel A: Prevention of iron deficiency by milk fortification. Acta Paediatr Scand Suppl. 1989;361:109-13. Saturation of Transferrin less than 9% was present in 33.8% and serum ferritin less than 10 micrograms/l in 39.1% of the nonfortified infants. Initially a field study involving the simple addition of ferrous sulfate to a low-fat powdered milk was only partially successful due to the relatively low iron absorption from this product. |
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| 2458347 | Yariv J, Kalb AJ, Helliwell JR, Papiz MZ, Bauminger ER, Nowik I: Chemical and Mossbauer spectroscopic evidence that iron-containing concanavalin A is a ferritin. J Biol Chem. 1988 Sep 25;263(27):13508-10. |
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| 12746164 | Tavil B, Sipahi T, Gokce H, Akar N: Effect of twice weekly versus daily iron treatment in Turkish children with iron deficiency anemia. Pediatr Hematol Oncol. 2003 Jun;20(4):319-26. With respect to certain parameters, such as red cell distribution, serum iron binding capacity, transferrin saturation, transferrin receptor, and transferrin receptor/log ferritin, however, intermittent treatment was superior to the conventional treatment method (p <.05). |
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| 18376840 | He WL, Feng Y, Li XL, Yang XE: Comparison of iron uptake from reduced iron powder and FeSO4 using the Caco-2 cell model: effects of and pH. J Agric Food Chem. 2008 Apr 23;56(8):2637-42. Epub 2008 Apr 1. The cell ferritin formation is used as a marker of iron uptake. |
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| 7257364 | Dallman PR: Iron deficiency: diagnosis and treatment. West J Med. 1981 Jun;134(6):496-505. Other laboratory tests that may be helpful in selected cases include determining serum ferritin, transferrin saturation or erythrocyte values. However, in most cases, a simple therapeutic trial with ferrous sulfate may be instituted on the basis of history and a screening test alone. |
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| 14704300 | Binkoski AE, Kris-Etherton PM, Beard JL: supplementation does not affect the susceptibility of LDL to oxidative modification in women with low iron status. J Nutr. 2004 Jan;134(1):99-103. In addition, subjects received either a supplement containing 160 mg of ferrous sulfate (50 mg elemental iron) or a placebo twice daily [supplement group received a total of 320 mg ferrous sulfate (100 mg elemental iron) daily]. After supplementation, serum ferritin differed between the supplement and placebo groups (P=0.008). |
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| 19125674 | Fagan RP, Dunaway CE, Bruden DL, Parkinson AJ, Gessner BD: Controlled, household-randomized, open-label trial of the effect of treatment of Helicobacter pylori infection on iron deficiency among children in rural Alaska: results at 40 months. J Infect Dis. 2009 Mar 1;199(5):652-60. METHODS: We enrolled 219 children 7-11 years old who had H. pylori infection (as diagnosed by (13) C-labeled urea breath test) and iron deficiency (serum ferritin level, <22.47 pmol/L) in a controlled, household-randomized trial of the effect of treatment of H. pylori on iron deficiency and anemia (hemoglobin level, <115 g/L). |
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| 19432567 | Chan KK, Chan BC, Lam KF, Tam S, Lao TT: supplement in pregnancy and development of gestational diabetes--a randomised placebo-controlled trial. BJOG. 2009 May;116(6):789-97; discussion 797-8. Maternal Hb and ferritin levels were higher in the iron supplement group at delivery (P < 0.001 and P= 0.003, respectively). |
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| 10850644 | Skikne BS, Ahluwalia N, Fergusson B, Chonko A, Cook JD: Effects of erythropoietin therapy on iron absorption in chronic renal failure. J Lab Clin Med. 2000 Jun;135(6):452-8. The absorption of 50 mg of iron as ferrous sulfate increased 2.4-fold from 3.8% to 9.4% (P < .05) when given without food and 4.2-fold from 1.4% to 5.9% (P < .05) when given with food after erythropoietin administration. After adjusting for changes in iron stores with serum ferritin after erythropoietin therapy, the enhanced erythropoiesis associated with erythropoietin therapy increased absorption about 2-fold, which was similar to the response observed previously in normal subjects. |
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| 18775429 | Sarker SA, Mahmud H, Davidsson L, Alam NH, Ahmed T, Alam N, Salam MA, Beglinger C, Gyr N, Fuchs GJ: Causal relationship of Helicobacter pylori with iron-deficiency anemia or failure of iron supplementation in children. Gastroenterology. 2008 Nov;135(5):1534-42. Epub 2008 Aug 5. METHODS: We randomized 200 Hp-infected children (positive urea breath test) 2-5 years of age with IDA (hemoglobin level <110 g/L; serum ferritin level <12 microg/L; and soluble transferrin receptor > 8.3 mg/L) or ID (serum ferritin level <12 microg/L or soluble transferrin receptor level > 8.3 mg/L) to 1 of 4 regimens: 2-week anti-Hp therapy (amoxicillin, clarithromycin, and plus 90-day oral ferrous sulfate (anti-Hp plus iron), 2-week anti-Hp therapy alone, 90-day oral iron alone, or placebo. |
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| 17977537 | Ziaei S, Mehrnia M, Faghihzadeh S: status markers in nonanemic pregnant women with and without iron supplementation. Int J Gynaecol Obstet. 2008 Feb;100(2):130-2. Epub 2007 Oct 31. METHODS: In a randomized, double-blind, placebo-controlled trial 244 women who had a hemoglobin concentration of 13.2 g/dL or greater and a serum ferritin level higher than 15 microg/L between the 13th and 18th week of pregnancy took either one 150-mg tablet of ferrous sulfate daily or placebo during their pregnancies. |
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| 1536576 | de Silva D, Miller DM, Reif DW, Aust SD: In vitro loading of apoferritin. Arch Biochem Biophys. 1992 Mar;293(2):409-15. Isoelectric focusing and amino acid analysis of the differently loaded ferritins showed that ferrous ammonium loading of apoferritin resulted in the depletion of the basic amino acids, and probably as a result of protein oxidation. |
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| 19073791 | Ziegler EE, Nelson SE, Jeter JM: supplementation of breastfed infants from an early age. Am J Clin Nutr. 2009 Feb;89(2):525-32. Epub 2008 Dec 10. Blood concentrations of ferritin, transferrin receptor, hemoglobin, and red cell indexes were determined at bimonthly intervals. (7 mg/d as multivitamin preparation with ferrous sulfate) or placebo (multivitamin preparation without iron) was given from 1 to 5.5 mo of age. |
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| 11533326 | Zlotkin S, Arthur P, Antwi KY, Yeung G: Randomized, controlled trial of single versus 3-times-daily ferrous sulfate drops for treatment of anemia. Pediatrics. 2001 Sep;108(3):613-6. Hemoglobin and serum ferritin values were measured at baseline and at the end of the study. |
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| 18370395 | Laparra JM, Tako E, Glahn RP, Miller DD: Inulin affects iron dialyzability from FeSO4 and FeEDTA solutions but does not alter Fe uptake by Caco-2 cells. J Agric Food Chem. 2008 Apr 23;56(8):2846-51. Epub 2008 Mar 28. Cell ferritin formation was used as a measure of Fe uptake. |
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| 19245362 | Pieracci FM, Henderson P, Rodney JR, Holena DN, Genisca A, Ip I, Benkert S, Hydo LJ, Eachempati SR, Shou J, Barie PS: Randomized, double-blind, placebo-controlled trial of effects of enteral iron supplementation on anemia and risk of infection during surgical critical illness. Surg Infect. 2009 Feb;10(1):9-19. METHODS: Anemic, critically ill surgical patients with an expected intensive care unit length of stay (ULOS) > or= 5 days were randomized to either enteral iron supplementation (ferrous sulfate 325 mg three times daily) or placebo until hospital discharge. Outcomes included hematocrit, iron markers (i.e., serum concentrations of iron, ferritin, and erythrocyte zinc [eZPP]), red blood cell (RBC) transfusion, transfusion rate (mL RBC/study day), nosocomial infection, antibiotic days, study length of stay (LOS), ULOS, and death. |
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| 2628746 | Bergmann R, Bergler H, Moshoudis E, Bergmann E, Lachmann E, Bergmann KE: [Preventing iron deficiency in breast-fed infants by suitable supplementary food. Monatsschr Kinderheilkd. 1989 Dec;137(12):775-9. At 6 months of age values of hemoglobin, MCV, serum iron, ferritin, and transferrin saturation were higher in the meat dinner group compared to the cereal first group. |
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| 12311947 | Zhu SM, Liu ZY: [The restoration of serum ferritin level of stainless steel ring IUD users after iron supplementary (author's transl)] Zhe Jiang Yi Ke Da Xue Xue Bao. 1982;11(2):52-4. |
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| 3788834 | Walter T, Arredondo S, Arevalo M, Stekel A: Effect of iron therapy on phagocytosis and bactericidal activity in neutrophils of iron-deficient infants. Am J Clin Nutr. 1986 Dec;44(6):877-82. All infants had hemoglobins less than 11 mg/dL with low saturation of transferrin and serum ferritin but were otherwise in good health. After 3-5 days of ferrous sulfate administration, there was no significant improvement. |
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| 17002471 | Zhu L, Glahn RP, Yeung CK, Miller DD: uptake by Caco-2 cells from NaFeEDTA and FeSO4: Effects of pH, and a Fe (II) chelating agent. J Agric Food Chem. 2006 Oct 4;54(20):7924-8. Ferritin formation in the cells was used as the indicator of iron uptake. |
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| 19070025 | Eftekhari MH, Eshraghian MR, Mozaffari-Khosravi H, Saadat N, Shidfar F: Effect of iron repletion and correction of iron deficiency on thyroid function in iron-deficient Iranian adolescent girls. Pak J Biol Sci. 2007 Jan 15;10(2):255-60. Participants were randomly assigned to one of two groups and treated with a 300 mg ferrous sulfate 5 times/week (n = 47) and placebo 5 times/week (n = 47) for 12 weeks. Blood samples were collected and assayed for hemoglobin, hematocrit, serum ferritin, iron, total iron binding capacity (TIBC), Thyroid stimulating hormone (TSH), total (TT4), total (TT3), free thyroid hormones (FT4 and FT3), resin uptake (T3RU), reverse (rT3), and albumin concentrations. |
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| 8825405 | Abrams SA, O'Brien KO, Wen J, Liang LK, Stuff JE: Absorption by 1-year-old children of an iron supplement given with cow's milk or juice. Pediatr Res. 1996 Jan;39(1):171-5. In this study, we used a two-tracer stable isotope technique to determine Fe absorption from a 5-mg dose of stable isotopically enriched (57Fe or 58Fe) ferrous sulfate given with cow's milk (CM) compared with the same dose given with apple juice. Fe absorption from the dose given with juice was significantly negatively correlated with serum ferritin (n = 9, r = -0.70, p < 0.05). |
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| 12499347 | de Silva A, Atukorala S, Weerasinghe I, Ahluwalia N: supplementation improves iron status and reduces morbidity in children with or without upper respiratory tract infections: a randomized controlled study in Colombo, Sri Lanka. Am J Clin Nutr. 2003 Jan;77(1):234-41. supplementation significantly improved iron status by increasing hemoglobin (P < 0.001) and serum ferritin (P < 0.001) concentrations from baseline values in the children with or without infection. Subjects in both groups were supplemented with ferrous sulfate (60 mg Fe) or placebo once daily for 8 wk. |
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| 2874330 | Rosove MH, Perloff JK, Hocking WG, Child JS, Canobbio MM, Skorton DJ: Chronic hypoxaemia and decompensated erythrocytosis in cyanotic congenital heart disease. Lancet. 1986 Aug 9;2(8502):313-5. In one extreme case, erythropoiesis remained persistently iron deficient despite normal serum iron and ferritin levels. "Decompensated erythrocytosis" is an apt term for the excessive erythrocytic response and the associated phenomena. |
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| 15510758 | Siddiqui IA, Rahman MA, Jaleel A: Efficacy of daily vs. weekly supplementation of iron in schoolchildren with low iron status. J Trop Pediatr. 2004 Oct;50(5):276-8. Hemoglobin (Hb), hematocrit (Hct), serum iron, total iron binding capacity (TIBC), and serum ferritin were determined before the start of the study. Ferrous sulfate (200 mg) was given daily to the daily supplementation group and once-weekly to the weekly supplementation group for 2 months. |
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| 7647009 | Skikne BS, Whittaker P, Cooke A, Cook JD: Ferritin excretion and iron balance in humans. Br J Haematol. 1995 Jul;90(3):681-7. |
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| 7388178 | Wheby MS: Effect of iron therapy on serum ferritin levels in iron-deficiency anemia. . Blood. 1980 Jul;56(1):138-40. To evaluate this in adults, 14 patients with iron-deficiency anemia were studied prior to and after beginning treatment with oral ferrous sulfate in standard dose, 300 mg t.i.d., or double dose, 600 mg t.i.d. |
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| 16332661 | Zimmermann MB, Winichagoon P, Gowachirapant S, Hess SY, Harrington M, Chavasit V, Lynch SR, Hurrell RF: Comparison of the efficacy of wheat-based snacks fortified with ferrous sulfate, electrolytic iron, or -reduced elemental iron: randomized, double-blind, controlled trial in Thai women. Am J Clin Nutr. 2005 Dec;82(6):1276-82. RESULTS: Between baseline and 35 wk, geometric mean serum ferritin (SF) increased significantly in all 3 groups receiving iron (P < 0.01), and geometric mean serum transferrin receptor (TfR) decreased significantly in the groups receiving ferrous sulfate and electrolytic iron (P < 0.05). |
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| 16316362 | Van Wyck DB, Roppolo M, Martinez CO, Mazey RM, McMurray S: A randomized, controlled trial comparing IV iron to oral iron in anemic patients with nondialysis-dependent CKD. Kidney Int. 2005 Dec;68(6):2846-56. METHODS: In a randomized, controlled multicenter trial, we compared the efficacy of iron given as 1 g in divided IV doses over 14 days, with that of ferrous sulfate, given 325 mg orally thrice daily for 56 days in patients with ND-CKD stages 3 to 5, Hb < or =11 g/dL, TSAT < or =25%, and ferritin < or =300 ng/mL. |
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| 19332906 | Monajemzadeh SM, Zarkesh MR: Iron deficiency anemia in infants aged 12-15 months in Ahwaz, Iran. Indian J Pathol Microbiol. 2009 Apr-Jun;52(2):182-4. The mean corpuscular volume and hemoglobin (Hb), serum ferritin and hematocrit levels were measured. The tendency to have IDA in infants fed with cow's milk and infants who did not receive ferrous sulfate was higher than in the other subjects. |
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| 12776894 | Siddiqui IA, Jaleel A, Rahman MA: Preventive strategy to control iron deficiency anemia in children and adults. J Pak Med Assoc. 2003 Apr;53(4):131-3. OBJECTIVE: To compare improvement in hemoglobin, mean corpuscular volume, mean corpuscular hemoglobin and ferritin levels in children aged 5-10 years and women of reproductive age (15-45) supplemented with daily oral and once weekly with single and double dose of ferrous sulphate. METHOD: Twenty children received 200 mg ferrous sulfate daily and 20 received the same dose once weekly for two months. |
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| 18371137 | Kulnigg S, Stoinov S, Simanenkov V, Dudar LV, Karnafel W, Garcia LC, Sambuelli AM, D'Haens G, Gasche C: A novel intravenous iron formulation for treatment of anemia in inflammatory bowel disease: the ferric carboxymaltose (FERINJECT) randomized controlled trial. Am J Gastroenterol. 2008 May;103(5):1182-92. Epub 2008 Mar 26. BACKGROUND AIMS: Anemia is a common complication of inflammatory bowel diseases (IBD) This multicenter study tested the noninferiority and safety of a new intravenous iron preparation, ferric carboxymaltose (FeCarb), in comparison with oral ferrous sulfate (FeSulf) in reducing iron deficiency anemia (IDA) in IBD. Median ferritin increased from 5.0 to 323.5 mug/L at week 2, followed by a continuous decrease in the FeCarb group (43.5 mug/L at week 12). |
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| 19469261 | Nikitin EN, Krasnoperova OV, Nikitin IuE: [Experience in the treatment of iron deficiency anemia with ferro-folgamma]. Klin Med. 2009;87(3):64-7. Criteria for the efficiency were changes in clinical symptoms of anemia, hemoglobin level, erythrocyte and reticulocyte counts, packed cell volume, erythrocyte indices (mean erythrocyte volume, average content and concentration of hemoglobin in erythrocytes), erythropoietin level, and characteristics of iron metabolism (serum iron and ferritin levels, total iron-binding capacity of the serum, coefficient of ferritin saturation with iron), and drug tolerance. |
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| 6679216 | Rao KR, Patel AR, Honig GR, Vida LN, McGinnis PR: Iron deficiency and sickle cell anemia. . Arch Intern Med. 1983 May;143(5):1030-2. In a patient with sickle cell anemia, iron deficiency was accompanied by hypochromic, microcytic RBCs, absence of bone marrow iron, and a low serum ferritin level. |
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| 15531676 | Alarcon K, Kolsteren PW, Prada AM, Chian AM, Velarde RE, Pecho IL, Hoeree TF: Effects of separate delivery of zinc or zinc and on hemoglobin response, growth, and diarrhea in young Peruvian children receiving iron therapy for anemia. Am J Clin Nutr. 2004 Nov;80(5):1276-82. The increase in serum ferritin in the FS group (24.5 mug/L) was significantly less than that in the other 2 groups (33.0 and 30.8 mug/L in the FSZn and FSZnA groups, respectively). Anemic children aged 6-35 mo were assigned to 3 treatment groups: ferrous sulfate (FS; n = 104), ferrous sulfate and zinc (FSZn; n = 109), and ferrous sulfate, zinc and (FSZnA; n = 110). |
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| 7960194 | Dunea G, Swagel MA, Bodiwala U, Arruda JA: Intra-dialytic oral iron therapy. Int J Artif Organs. 1994 May;17(5):261-4. In these studies the patients received supervised iron therapy as 3-4 ferrous sulfate (325 mg) tablets during each dialysis. |
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| 12097667 | Chung CS, Nagey DA, Veillon C, Patterson KY, Jackson RT, Moser-Veillon PB: A single 60-mg iron dose decreases zinc absorption in lactating women. J Nutr. 2002 Jul;132(7):1903-5. This study determined whether a single 60-mg dose of ferrous sulfate interferes with fractional zinc absorption (FZA) at 7-9 wk of lactation. |
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| 7112553 | Tanno Y, Arai S, Takishima T: -containing proteins augment responses of human lymphocytes to phytohemagglutinin and pokeweek mitogen in serum-free medium. Tohoku J Exp Med. 1982 Jul;137(3):335-43. Hemoglobin, transferrin and ferritin enhanced the incorporation of 3H- into DNA after PHA-stimulation of lymphocytes, while hemin, iron metal powder, ferrous sulfate, powder, and zinc have little effect. |
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| 1430787 | Baader SL, Bruchelt G, Handgretinger R, Niethammer D: A simple assay for determination of iron release from ferritin in neuroblastoma cells. J Biochem Biophys Methods. 1992 Aug;25(1):11-5. |
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| 1680462 | Bender FH, Piraino B: Polycythemia in diabetic patients on CAPD. Adv Perit Dial. 1991;7:77-80. Prior to the development of polycythemia, ferritin levels were low and ferrous sulfate therapy was begun at a time the Hct values were 36 to 40%. |
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| 16458655 | Siega-Riz AM, Hartzema AG, Turnbull C, Thorp J, McDonald T, Cogswell ME: The effects of prophylactic iron given in prenatal supplements on iron status and birth outcomes: a randomized controlled trial. Am J Obstet Gynecol. 2006 Feb;194(2):512-9. STUDY DESIGN: Eight hundred sixty-seven women in Raleigh, North Carolina, who were at < 20 weeks of gestation were enrolled; 429 of these women had hemoglobin levels of > or = 110 g/L and ferritin levels of > or = 40 microg/L and were assigned randomly to receive prenatal supplements with 30 mg of iron as ferrous sulfate (n = 218 women) or 0 mg of iron (n = 211 women) until 26 to 29 weeks of gestation. |
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| 1748105 | Lukaski HC, Hall CB, Siders WA: Altered metabolic response of iron-deficient women during graded, maximal exercise. Eur J Appl Physiol Occup Physiol. 1991;63(2):140-5. Metabolic responses during a standardized, progressive, maximal work capacity test on a cycle ergometer were studied in 11 women, mean age 28 (SEM 2) years, at admission to the study, after their body iron stores were depleted by diet, phlebotomy and menstruation for about 80 days and after iron repletion by diet for about 100 days, including daily iron supplementation (0.9 mmol iron as ferrous sulfate) for the last 14 days of repletion. depletion was characterized by a decline (P less than 0.05) in hemoglobin, ferritin and body iron balance. |
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| 10989766 | Kianfar H, Kimiagar M, Ghaffarpour M: Effect of daily and intermittent iron supplementation on iron status of high school girls. Int J Vitam Nutr Res. 2000 Jul;70(4):172-7. Among anemic subjects, changes in serum ferritin levels in 3 supplemented groups were significantly different from the control group. During a 3-month period, the test groups were given 150 mg ferrous sulfate tablets (50 mg Fe). |
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| 17509858 | Kalgaonkar S, Lonnerdal B: Effects of dietary factors on iron uptake from ferritin by Caco-2 cells. J Nutr Biochem. 2008 Jan;19(1):33-9. Epub 2007 May 16. |
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| 15231078 | de Souza AI, Batista Filho M, Ferreira LO, Figueiroa JN: [The effectiveness of three regimens using ferrous sulfate to treat anemia in pregnant women]. Rev Panam Salud Publica. 2004 May;15(5):313-9. The groups were compared for the values for hemoglobin (Hb) concentration, mean corpuscular volume, and ferritin before and after the treatment. |
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| 18607114 | Toblli JE, Cao G, Olivieri L, Angerosa M: Comparative study of gastrointestinal tract and liver toxicity of ferrous sulfate, iron amino chelate and iron polymaltose complex in normal rats. Pharmacology. 2008;82(2):127-37. Epub 2008 Jul 8. Ferritin was elevated (p < 0.01) in the IPC group versus FS and iron AC in the small intestine and liver. |
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| 12042158 | Belmonte Torras JA, Tusell Puigbert J, Piera Carreras A, Soler Palacin P, Aulesa Martinez C, Iglesias Berengue J: supplementation in a child with severe burns] . An Esp Pediatr. 2002 Jun;56(6):579-81. These findings were interpreted as a functional iron insufficiency, despite the increased ferritin value (219 ng/mL). We highlight the satisfactory outcome of the different hematologic values, with the development of reticulocyte crisis and normalization of hematological parameters after administration of 0.5 mg/kg/day of ferrous sulfate, plus iron corresponding to the follow-up milk formula and a regular diet for the child's age. |
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| 3325320 | Landucci G, Frontespezi S: Treatment of iron deficiency conditions in blood donors: controlled study of iron sulphate versus iron protein succinylate. J Int Med Res. 1987 Nov-Dec;15(6):379-82. The amount of stored iron, evaluated by serum ferritin levels, significantly increased in both treatment groups. |
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| 7997105 | Engelhardt R, Langkowski JH, Fischer R, Nielsen P, Kooijman H, Heinrich HC, Bucheler E: Liver iron quantification: studies in aqueous iron solutions, iron overloaded rats, and patients with hereditary hemochromatosis. Magn Reson Imaging. 1994;12(7):999-1007. For the noninvasive liver iron quantification by MRI in human iron overload diseases, fundamental relaxation mechanisms were studied in aqueous solutions with ferritin and other iron compounds, in experimentally iron overloaded rats, and in patients with iron overload diseases. |
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| 9239288 | Franco E, Hertrampf E, Hazbun J, Segu S, Illanes JC, Palacios L, Figueroa G, Orellana J: supplementation in Chilean Mapuche infants of the Cautin Province, Chile]. Arch Latinoam Nutr. 1996 Jun;46(2):118-21. A 1.8 ml iron supplementation of ferrous sulfate is administered for 90 days to 76 Mapuche infants, 12 months of age, male and female, from the rural area of the Cautin province of Chile. The iron nutrition is evaluated before and after the supplementation, through: hemoglobin, haematocrit, transferrin saturation and seric ferritin. |
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| 10731864 | Arvas A, Elgormus Y, Gur E, Alikasifoglu M, Celebi A: status in breast-fed full-term infants. Turk J Pediatr. 2000 Jan-Mar;42(1):22-6. Some of the infants (51) were later given appropriate complementary food besides breast-feeding (Group A) and some (42) were given ferrous sulfate (1 mg/kg/d) (Group B). Blood count and serum iron and ferritin measurements were done at four and six months of age. |
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| 9201139 | Rapetti MC, Donato H, de Galvagni A, Lubovitsky M, Lanzilotta M, Trepacka E, Burlando G, Weill R: Correction of iron deficiency with an iron-fortified fluid whole cow's milk in children: results of a pilot study. J Pediatr Hematol Oncol. 1997 May-Jun;19(3):192-6. PURPOSE: This study assesses the efficacy of an iron-fortified (15 mg Fe, as stabilized ferrous sulfate (SFE-171), per liter) fluid whole cow's milk (IFFWCM) for the treatment of mild iron deficiency in children. PATIENTS AND METHODS: Seventeen children (12 to 48 months old) with iron deficiency (serum iron (SI) < 60 micrograms/dl, transferrin saturation (TS) < 15%, serum ferritin (SF) < 15 ng/ml) were included in this study; 11 of them were anemic. |
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| 10721929 | Zavaleta N, Respicio G, Garcia T: Efficacy and acceptability of two iron supplementation schedules in adolescent school girls in Lima, Peru. J Nutr. 2000 Feb;130(2S Suppl):462S-464S. Adolescent girls (n = 312), 12-18 y old, were randomly assigned to one of the following three groups: 1) 60 mg iron as ferrous sulfate daily from Monday to Friday; 2) 60 mg iron as ferrous sulfate 2 d/wk and 3 d placebo (intermittent); 3) placebo, from Monday to Friday. Postintervention, hemoglobin (Hb), serum ferritin (SF) and free erythrocyte (FEP) were improved significantly in the iron-supplemented groups compared with placebo (P <0.05). |
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| 11880565 | Sungthong R, Mo-Suwan L, Chongsuvivatwong V, Geater AF: Once weekly is superior to daily iron supplementation on height gain but not on hematological improvement among schoolchildren in Thailand. J Nutr. 2002 Mar;132(3):418-22. The effects of once weekly and daily iron supplementation on hemoglobin (Hb), serum ferritin (SF), prevalence of anemia, weight and height are compared in this study. All children received Albendazole and then randomly received ferrous sulfate (300 mg/tablet) either daily or weekly, or a placebo for 16 wk. |
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| 19653920 | Biebinger R, Zimmermann MB, Al-Hooti SN, Al-Hamed N, Al-Salem E, Zafar T, Kabir Y, Al-Obaid I, Petry N, Hurrell RF: Efficacy of wheat-based biscuits fortified with microcapsules containing ferrous sulfate and or a new -reduced elemental iron: a randomised, double-blind, controlled trial in Kuwaiti women. Br J Nutr. 2009 Nov;102(9):1362-9. Epub 2009 Aug 5. |
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| 17296819 | Henry DH, Dahl NV, Auerbach M, Tchekmedyian S, Laufman LR: Intravenous ferric significantly improves response to epoetin alfa versus oral iron or no iron in anemic patients with cancer receiving chemotherapy. Oncologist. 2007 Feb;12(2):231-42. PURPOSE: To evaluate the safety and efficacy of intravenous (IV) ferric complex (FG), oral ferrous sulfate, or no iron to increase hemoglobin (Hb) in anemic cancer patients receiving chemotherapy and epoetin alfa. |
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| 11083968 | de la Torre Aguilar M, Gascon Jimenez FJ, Zapatero Martinez M, Guzman Cabanas J, Huertas Munoz D, Ruiz Gonzalez D, Jaraba Caballero P: [Prophylaxis of anemia of prematurity with erythropoietin. An Esp Pediatr. 2000 Sep;53(3):243-8. A ferrous sulfate supplement was also administered orally (4-6 mg/kg/day) with a multivitamin complex. |
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| 19230757 | Wang J, O'Reilly B, Venkataraman R, Mysliwiec V, Mysliwiec A: Efficacy of oral iron in patients with restless legs syndrome and a low-normal ferritin: A randomized, double-blind, placebo-controlled study. Sleep Med. 2009 Oct;10(9):973-5. Epub 2009 Feb 18. |
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| 11795240 | Nogueira NN, Marreiro DN, Parente JV, Cozzolino SM: [Utilization of different iron concentrations on pregnant adolescents also supplemented with zinc and Arch Latinoam Nutr. 2001 Sep;51(3):225-9. The main objective of this study was to investigate the effect of different concentrations of iron supplementation (80 and 120 mg of ferrous sulfate) together with (250 micrograms) and zinc (5 mg) on the hemoglobin concentration and iron stores (plasma ferritin) of pregnant adolescents. |
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| 7177278 | Marco-Franco JE, Alarcon A, Morey A, Piza C, Bestard J, Mairata S, Galmes A, Dalmau M: Serum ferritin in haemodialysis. Nephron. 1982;32(1):57-9. |
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| 7991433 | Aufricht C, Ties M, Wimmer M, Haschke F, Pietschnig B, Herkner K: supplementation in children after cardiopulmonary bypass for surgical repair of congenital heart disease. Pediatr Cardiol. 1994 Jul-Aug;15(4):167-9. Hemoglobin, reticulocytes, transferrin saturation, free erythrocyte and ferritin were measured, the final outcome measure being postoperative iron status on day 56. |
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| 18720044 | Westad S, Backe B, Salvesen KA, Nakling J, Okland I, Borthen I, Rognerud Jensen OH, Kolas T, Lokvik B, Smedvig E: A 12-week randomised study comparing intravenous iron versus oral ferrous sulphate for treatment of postpartum anemia. Acta Obstet Gynecol Scand. 2008;87(9):916-23. MAIN OUTCOME MEASURES: Hemoglobin, ferritin and quality of life assessed with the Medical Outcomes Study Short Form 36 (SF-36) and the Fatigue Scale. |
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| 2805611 | Vreugdenhil G, Baltus JA, van Eijk HG, Swaak AJ: Prediction and evaluation of the effect of iron treatment in anaemic RA patients. Clin Rheumatol. 1989 Sep;8(3):352-62. MCV showed highest specificity and predictive value (90 and 88%) and ferritin was the most valid predictor of a Hb rise within 6 weeks. |
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| 3341258 | Stekel A, Olivares M, Cayazzo M, Chadud P, Llaguno S, Pizarro F: Prevention of iron deficiency by milk fortification. Am J Clin Nutr. 1988 Feb;47(2):265-9. In a longitudinal study from age 3 to 15 mo, 276 term, healthy, spontaneously weaned infants received a full-fat acidified milk fortified with 15 mg of elemental Fe as ferrous sulfate and 100 mg of /100 g of powder and 278 control infants received milk without additives. Saturation of transferrin less than 9% was present in 33.8% and serum ferritin less than 10 micrograms/L in 39.1% of the nonfortified infants. |
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| 11328902 | Stoves J, Inglis H, Newstead CG: A randomized study of oral vs intravenous iron supplementation in patients with progressive renal insufficiency treated with erythropoietin. Nephrol Dial Transplant. 2001 May;16(5):967-74. Haemoglobin response and changes in red cell hypochromasia were similar in the two groups, but serum ferritin was significantly higher in the intravenous group. |
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| 15113952 | Pena-Rosas JP, Nesheim MC, Garcia-Casal MN, Crompton DW, Sanjur D, Viteri FE, Frongillo EA, Lorenzana P: Intermittent iron supplementation regimens are able to maintain safe maternal hemoglobin concentrations during pregnancy in Venezuela. J Nutr. 2004 May;134(5):1099-104. Women were randomly allocated to receive a 120-mg oral dose of iron as ferrous sulfate and 0.5 mg of weekly (n = 52) or 60 mg iron and 0.25 mg and a placebo twice weekly (n = 44). Hb, hematocrit, serum ferritin, and transferrin saturation were estimated at baseline and at 36-39 wk of gestation. |
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| 7342203 | Marco Franco JE, Alarcon Zurita A, Morey Molina A, Piza Bunola C, Bestard Palmer J, Mairata Bosch S, Galmes Llodra A, Dalmau Diana M: [Serum ferritin in hemodialysis. Rev Clin Esp. 1981 Dec 31;163(6):403-6. |
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| 6599114 | Jacobs P, Johnson G, Wood L: Oral iron therapy in human subjects, comparative absorption between ferrous salts and iron polymaltose. J Med. 1984;15(5-6):367-77. In the first study, bioavailability of iron from ferrous sulfate and the complex was defined at physiologic doses of 5 mg (Group 1: n = 14) and therapeutic doses of 50 mg (Group 2: n = 13). At all three dosage levels, iron is equally available from salt or polymaltose for hemoglobin synthesis (p greater than 0.20), and absorption negatively correlated with plasma ferritin (p less than 0.01). |
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| 19142566 | Roe MA, Collings R, Hoogewerff J, Fairweather-Tait SJ: Relative bioavailability of micronized, dispersible ferric added to an apple juice drink. Eur J Nutr. 2009 Mar;48(2):115-9. Epub 2009 Jan 13. Absorption from SunActive Fe was positively correlated (r = 0.97, P = 0.01) with absorption from ferrous sulphate, and negatively correlated with serum ferritin concentration (ferrous sulphate r = -0.81, P < 0.001; SunActive Fe r = -0.76, P = 0.01). |
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| 18234203 | Breymann C, Gliga F, Bejenariu C, Strizhova N: Comparative efficacy and safety of intravenous ferric carboxymaltose in the treatment of postpartum iron deficiency anemia. Int J Gynaecol Obstet. 2008 Apr;101(1):67-73. Epub 2008 Jan 29. OBJECTIVES: To compare the safety and efficacy of iron carboxymaltose with ferrous sulfate to treat iron deficiency anemia in the post partum. Ferritin levels were significantly higher. |
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| 15447900 | Hunt JR, Zeng H: absorption by heterozygous carriers of the HFE C282Y mutation associated with hemochromatosis. Am J Clin Nutr. 2004 Oct;80(4):924-31. CONCLUSIONS: HFE C282Y-heterozygous subjects did not absorb dietary iron more efficiently, even when foods were highly fortified with iron from ferrous sulfate and than did control subjects. |
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| 8002746 | Ovaert C, Bachy A: [Iron deficiency anemia is not always simple] . Arch Fr Pediatr. 1993 Oct;50(8):697-9. The serum iron was 1 microgram/dl, iron binding capacity (IBC) was 284 micrograms/dl and ferritin was 14.9 ng/ml. The patient was given ferrous sulfate but iron deficiency persisted at the ages of 11 months and 3 years, probably due to poor compliance. |
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| 11010941 | Roughead ZK, Hunt JR: Adaptation in iron absorption: iron supplementation reduces nonheme-iron but not heme-iron absorption from food. Am J Clin Nutr. 2000 Oct;72(4):982-9. DESIGN: In a randomized, placebo-controlled trial, heme- and nonheme-iron absorption by healthy men and women (n = 57) were measured before and after 12 wk of supplementation with 50 mg Fe/d as ferrous sulfate. Serum and fecal ferritin were measured during supplementation and for 6 mo thereafter. |
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| 10444519 | Smirnov IM, Bailey K, Flowers CH, Garrigues NW, Wesselius LJ: Effects of TNF-alpha and IL-1beta on iron metabolism by A549 cells and influence on cytotoxicity. Am J Physiol. 1999 Aug;277(2 Pt 1):L257-63. However, the synthesis of ferritin stimulated by metal exposure for intracellular iron storage is normally protective. |
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| 3945045 | Harju E, Lindberg H: The increase of body iron stores estimated by the increase of serum ferritin concentration during ferrous sulphate treatment after gastrointestinal surgery. JPEN J Parenter Enteral Nutr. 1986 Jan-Feb;10(1):66-9. |
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| 18791976 | Angeles-Agdeppa I, Capanzana MV, Barba CV, Florentino RF, Takanashi K: Efficacy of iron-fortified rice in reducing anemia among schoolchildren in the Philippines. Int J Vitam Nutr Res. 2008 Mar;78(2):74-86. Greater, significant increases were also observed in plasma ferritin in the fortified groups than in the Control group from baseline to 6 months. Design: 180 randomly selected 6-to 9-year-old anemic children were randomly allocated to three groups in a double-blinded manner: One group received iron-enriched rice (IER) with extruded iron premix rice (IPR) using ferrous sulfate as fortificant (ExFeSO4); the second group received IER with extruded IPR using micronized dispersible ferric (ExFeP80); and the third group received non-fortified rice (Control). |
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| 12499339 | Murray-Kolb LE, Welch R, Theil EC, Beard JL: Women with low iron stores absorb iron from soybeans. Am J Clin Nutr. 2003 Jan;77(1):180-4. Because much of soybean iron is in ferritin [distinct from the poorly bioavailable iron in cereals resulting from interactions between Fe (III), and proteins in the meal], soybeans provide a target for manipulating seed iron composition to achieve increased iron bioavailability. DESIGN: Eighteen women, most with marginal iron deficiency, consumed meals with intrinsically labeled ((55) Fe) soybeans (hydroponically grown and nonnodulating) as soup (n = 11) or muffins (n = 7) and a reference dose of (59) Fe as ferrous sulfate in solution. |
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| 10837299 | Bovell-Benjamin AC, Viteri FE, Allen LH: absorption from ferrous bisglycinate and ferric trisglycinate in whole maize is regulated by iron status. Am J Clin Nutr. 2000 Jun;71(6):1563-9. In studies 2A and 2B, absorption from all sources was strongly inversely related to serum ferritin, with geometric means of 32.5% (iron 9.1% (bisglycinate), and 15.3% (trisglycinate). OBJECTIVE: The objective of this study was to compare iron absorption from ferrous sulfate, ferrous bisglycinate, and ferric trisglycinate in whole-maize meal; to determine whether iron from ferrous bisglycinate and ferrous sulfate exchanges in the intestinal pool; and to assess iron absorption from ferrous bisglycinate and ferric trisglycinate over a range of iron statuses. |
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| 17338998 | Beck-da-Silva L, Rohde LE, Pereira-Barretto AC, de Albuquerque D, Bocchi E, Vilas-Boas F, Moura LZ, Montera MW, Rassi S, Clausell N: Rationale and design of the IRON-HF study: a randomized trial to assess the effects of iron supplementation in heart failure patients with anemia. J Card Fail. 2007 Feb;13(1):14-7. METHODS AND RESULTS: IRON-HF study is a multicenter, investigator initiated, randomized, double-blind, placebo controlled trial that will enroll anemic HF patients with relatively preserved renal function, low transferrin saturation, low iron levels, and low to moderately elevated ferritin levels. Interventions are iron intravenously 200 mg once per week for 5 weeks, ferrous sulfate 200 mg by mouth 3 times per day for 8 weeks, or placebo. |
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| 12279567 | Zhu SM, Liu ZY: [The decrease of serum ferritin level in women using intrauterine device and its restoration after iron-loading (author's transl)] Ying Yang Xue Bao. 1983 Feb;5(1):19-24. |
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| 17206511 | Horl WH: therapy for renal anemia: how much needed, how much harmful? . Pediatr Nephrol. 2007 Apr;22(4):480-9. Epub 2007 Jan 6. status can be monitored by different parameters such as ferritin, transferrin saturation, percentage of hypochromic red blood cells, and/or the reticulocyte hemoglobin content, but an increased erythropoietic response to iron supplementation is the most widely accepted reference standard of iron-deficient erythropoiesis. |
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| 2207011 | Cook JD, Dassenko S, Skikne BS: Serum transferrin receptor as an index of iron absorption. Br J Haematol. 1990 Aug;75(4):603-9. To determine whether the latter plays a role in the regulation of iron absorption, we examined the relationship between serum receptor, serum ferritin and iron absorption in healthy subjects. |
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| 3693637 | Jenkins KJ, Hidiroglou M: Effect of excess iron in milk replacer on calf performance. J Dairy Sci. 1987 Nov;70(11):2349-54. Milk replacers containing 100, 500, 1000, 2000, or 5000 ppm iron were fed to 3-d-old calves for 6 wk to estimate the lowest amount of dietary iron (added as ferrous sulfate) that would reduce calf performance. At 100 ppm iron intake, nonheme iron in liver, spleen, and kidney was composed of similar proportions of ferritin and hemosiderin, but at 5000 ppm iron intake, hemosiderin predominated in these tissues. |
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| 2393012 | Calvo EB, Gnazzo N: Prevalence of iron deficiency in children aged 9-24 mo from a large urban area of Argentina. Am J Clin Nutr. 1990 Sep;52(3):534-40. Mean corpuscular volume was less than 73 fL in 28.2% of subjects, free erythrocyte was greater than 1.77 mumol/L erythrocytes in 57.1%, and serum ferritin was less than 12 micrograms/L in 60.2%.incidence of two or three abnormal values for iron status indicators was 46.1%. |
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| 1730148 | Jaeschke H, Kleinwaechter C, Wendel A: -dependent reductive stress and ferritin-bound iron in allyl -induced lipid peroxidation in vivo: the protective effect of Chem Biol Interact. 1992 Jan;81(1-2):57-68. Ferrous sulfate (0.36 mmol/kg) or a low dose of ally (0.6 mmol/kg) itself caused only minor lipid peroxidation and injury to the liver within 1 h. |
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| 17175555 | Cha'on U, Valmas N, Collins PJ, Reilly PE, Hammock BD, Ebert PR: Disruption of iron homeostasis increases phosphine toxicity in Caenorhabditis elegans. Toxicol Sci. 2007 Mar;96(1):194-201. Epub 2006 Dec 14. In this report, we demonstrate the following dose-dependent actions of phosphine, in vitro: (1) reduction of ferric iron (Fe3+) to ferrous iron (Fe2+), (2) release of iron from horse ferritin, (3) and the peroxidation of lipid as a result of iron release from ferritin. |
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| 17542112 | Faqih AM, Kakish SB, Izzat M: Effectiveness of intermittent iron treatment of two- to six-year-old Jordanian children with iron-deficiency anemia. Food Nutr Bull. 2006 Sep;27(3):220-7. All of the children received medicinal iron drops at a dosage of 5 mg elemental iron as ferrous sulfate per kilogram of body weight. Anemic children underwent further screening for iron deficiency, defined as serum ferritin level < or =12 microg/L. |
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| 9763580 | Suominen P, Punnonen K, Rajamaki A, Irjala K: Serum transferrin receptor and transferrin receptor-ferritin index identify healthy subjects with subclinical iron deficits. Blood. 1998 Oct 15;92(8):2934-9. |
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| 7571614 | Roszkowska-Blaim M, Korniszewska J, Makarewicz W: [Assessment of iron absorption in children with chronic renal insufficiency]. Wiad Lek. 1994 Sep;47(17-18):659-65. The curves of iron absorption at serum ferritin level 250-500 ng/ml pointed to impaired absorption and depended on the initial TSI value and initial iron level in the serum. |
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| 20016013 | Zimmermann MB, Harrington M, Villalpando S, Hurrell RF: Nonheme-iron absorption in first-degree relatives is highly correlated: a stable-isotope study in mother-child pairs. Am J Clin Nutr. 2010 Mar;91(3):802-7. Epub 2009 Dec 16. DESIGN: We provided 72 test meals based on degermed maize flour and milk powder and fortified with [(57) Fe] ferrous or [(58) Fe] ferrous sulfate to healthy Mexican preschool children [n = 18; mean (+/-SD) age: 3.6 +/- 1.0 y] and their mothers [n = 18; mean (+/-SD) age: 28.0 +/- 5.2 y]. After adjustment for serum ferritin, the significant difference in absorption between mothers and their children disappeared. |
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| 1542922 | Biesma DH, Kraaijenhagen RJ, Poortman J, Marx JJ, van de Wiel A: The effect of oral iron supplementation on erythropoiesis in autologous blood donors. Transfusion. 1992 Feb;32(2):162-5. During the preoperative period, in which 4 units of blood were collected, 17 patients received oral iron supplementation with 287 mg of ferrous sulfate (105 mg of elemental iron/day), while 17 patients did not use any iron supplementation. Oral iron supplementation during the 4-week preoperative period lessened the decrease in ferritin levels after two phlebotomies. |
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| 8147338 | Li R, Chen X, Yan H, Deurenberg P, Garby L, Hautvast JG: Functional consequences of iron supplementation in iron-deficient female cotton mill workers in Beijing, China. Am J Clin Nutr. 1994 Apr;59(4):908-13. In the iron-treated group mean hemoglobin (Hb) increased from 114 to 127 g/L (P < 0.001), mean serum ferritin increased from 9.7 to 30.0 micrograms/L (P < 0.001), and mean free erythrocyte decreased from 1.01 to 0.49 mumol/L (P < 0.001). |
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| 10992272 | Anderson D, Yardley-Jones A, Vives-Bauza C, Chua-Anusorn W, Cole C, Webb J: Effect of iron salts, haemosiderins, and chelating agents on the lymphocytes of a thalassaemia patient without chelation therapy as measured in the comet assay. Teratog Carcinog Mutagen. 2000;20(5):251-64. Ferritin iron appears to be more available than haemosiderin iron in reactions leading to DNA damage. |
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| 3763274 | Hertrampf E, Cayazzo M, Pizarro F, Stekel A: Bioavailability of iron in soy-based formula and its effect on iron nutriture in infancy. Pediatrics. 1986 Oct;78(4):640-5. bioavailability from a soy formula (Prosobee-PP 710) (iron added as ferrous sulfate: 12 mg/L; 54 mg/L) was examined in 16 adult women using the extrinsic radioactive tag method. Infants fed soy formula and iron-fortified cow's milk had similar mean values of hemoglobin, mean corpuscular volume, transferrin saturation, free erythrocyte and serum ferritin; both formula groups differed significantly (P less than .05) from the breast-fed group in all measurements except free erythrocyte |
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| 19406557 | Bencaiova G, von Mandach U, Zimmermann R: prophylaxis in pregnancy: intravenous route versus oral route. Eur J Obstet Gynecol Reprod Biol. 2009 Jun;144(2):135-9. Epub 2009 Apr 29. There was a significant difference of repleted iron stores before delivery (ferritin> 50 microg/l) in the group with three intravenous iron doses in comparison to the oral iron group (49 vs. 14%; p <0.001). |
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| 19149890 | Pedrazzini B, Waldvogel S, Cornuz J, Vaucher P, Bize R, Tissot JD, Pecoud A, Favrat B: The impact of iron supplementation efficiency in female blood donors with a decreased ferritin level and no anaemia. Trials. 2009 Jan 16;10:4. Our objective is to determine the clinical effect of iron supplementation on fatigue in female blood donors without anaemia, but with a mean serum ferritin < or = 30 ng/ml. |
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| 12763985 | Verdon F, Burnand B, Stubi CL, Bonard C, Graff M, Michaud A, Bischoff T, de Vevey M, Studer JP, Herzig L, Chapuis C, Tissot J, Pecoud A, Favrat B: supplementation for unexplained fatigue in non-anaemic women: double blind randomised placebo controlled trial. BMJ. 2003 May 24;326(7399):1124. Most had a low serum ferritin concentration; |
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| 3749034 | Bergamaschi G, Eng MJ, Huebers HA, Finch CA: The effect of transferrin saturation on internal iron exchange. Proc Soc Exp Biol Med. 1986 Oct;183(1):66-73. Radioiron introduced into the lumen of the gut as ferrous sulfate and as transferrin-bound iron was absorbed about half as well in iron-infused animals, and absorbed iron was localized in the liver. The decrease in absorption was associated with an increase in mucosal iron and ferritin content produced by the iron infusion. |
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| 1869005 | Barrada M, Pateisky N, Schatten C, Salzer H, Vavra N, Spona J, Sevelda P: [Ferritin level in newborn infants after prepartal iron medication] . Geburtshilfe Frauenheilkd. 1991 May;51(5):366-8. |
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| 17963760 | Ziaei S, Janghorban R, Shariatdoust S, Faghihzadeh S: The effects of iron supplementation on serum and zinc levels in pregnant women with high-normal hemoglobin. Int J Gynaecol Obstet. 2008 Feb;100(2):133-5. Epub 2007 Oct 25. From the 20th week until the end of pregnancy the case group received one ferrous sulfate tablet containing 50 mg elemental iron daily, while the control group received placebo. Hemoglobin, ferritin, and zinc levels at 24-28 and 32-36 weeks of pregnancy were measured and compared. |
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| 1431504 | Skikne BS, Cook JD: Effect of enhanced erythropoiesis on iron absorption. J Lab Clin Med. 1992 Nov;120(5):746-51. The absorption of heme and nonheme iron from a standard meal was measured in nine subjects, and the absorption of a therapeutic dose of ferrous sulfate given with or without food was determined in an additional 11 subjects. To assess the effect of erythropoiesis independently of the induced changes in iron status, the absorption data were adjusted to a common serum ferritin level. |
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| 18752926 | Navas-Carretero S, Perez-Granados AM, Sarria B, Vaquero MP: absorption from meat pate fortified with ferric in iron-deficient women. Nutrition. 2009 Jan;25(1):20-4. Epub 2008 Aug 26. We compared in iron-deficient women the bioavailability of iron of three meat pate products enriched with ferrous sulfate, ferric encapsulated in liposomes, or ferric encapsulated in liposomes plus a hemoglobin-based meat pigment. METHODS: Seventeen women with low iron stores (ferritin <30 microg/L) took part in a three-way, randomized, crossover, double-blind postprandial intervention. |
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| 3566867 | Kaltwasser JP, Werner E, Niechzial M: Bioavailability and therapeutic efficacy of bivalent and trivalent iron preparations. Arzneimittelforschung. 1987 Jan;37(1A):122-9. There was also a small but significant rise in serum ferritin during the oral treatment in both treatment groups. |
1(0,0,0,1) | Details |
| 9580762 | Walter T, Pino P, Pizarro F, Lozoff B: Prevention of iron-deficiency anemia: comparison of high- and low-iron formulas in term healthy infants after six months of life. J Pediatr. 1998 Apr;132(4):635-40. STUDY DESIGN: Healthy Chilean 6-month-old infants (without iron-deficiency anemia, born at term weighing > or 3.0 kg) who were totally or partially weaned from the breast were randomly allocated in a double-blind fashion to receive high-iron (n = 430) or low-iron formula (n = 405), containing an average of 12.7 mg/L or 2.3 mg/L, respectively, of elemental iron as ferrous sulfate. Nevertheless, infants receiving high-iron formula had somewhat higher levels of hemoglobin and serum ferritin, greater mean cell volumes, and lower erythrocyte levels (p < 0.005). |
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| 11916761 | Brownlie T 4th, Utermohlen V, Hinton PS, Giordano C, Haas JD: Marginal iron deficiency without anemia impairs aerobic adaptation among previously untrained women. Am J Clin Nutr. 2002 Apr;75(4):734-42. RESULTS: Six weeks of iron supplementation significantly improved serum ferritin and serum transferrin receptor (sTfR) concentrations and transferrin saturation without affecting hemoglobin concentrations or hematocrit. |
1(0,0,0,1) | Details |
| 11840762 | Lin X, Tang Y, Long Z: [Effects of and iron supplementation on the improvement of iron status and immunological function in preschool children]. Zhonghua Yu Fang Yi Xue Za Zhi. 2001 Nov;35(6):374-7. METHODS: Serum concentration and hemoglobin (Hb), serum iron (SI), transferrin saturation (TS), serum ferritin (SF) were determined in 270 rural preschool children aged 3-7 years in Beijing, and the subjects were divided into four groups based on their determinations: control, lower serum lower iron, and both lower iron and serum Forty-one subjects who had lower iron and lower serum (< 1.12 mumol/L) were divided into two groups: one of them supplemented with 30 mg iron element (ferrous sulfate 0.15 g) once a day for 8 weeks, and the other group supplemented with iron and 12,500 IU twice a week for 8 weeks. |
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| 8602626 | Hartman KR, Barker JA: Microcytic anemia with iron malabsorption: an inherited disorder of iron metabolism. Am J Hematol. 1996 Apr;51(4):269-75. These children had severe microcytosis (MCV 48 fl, hemoglobin 7.5 g/dl) with decreased serum iron, elevated serum TIBC, and decreased serum ferritin, despite prolonged treatment with oral iron. An iron challenge study with an oral dose of 2 mg/kg elemental iron as ferrous sulfate documented iron malabsorption. |
1(0,0,0,1) | Details |
| 11053509 | Mumtaz Z, Shahab S, Butt N, Rab MA, DeMuynck A: Daily iron supplementation is more effective than twice weekly iron supplementation in pregnant women in Pakistan in a randomized double-blind clinical trial. J Nutr. 2000 Nov;130(11):2697-702. Anemic pregnant women (n = 191) were assigned to receive daily (200 mg ferrous sulfate) or twice weekly (2 x 200 mg ferrous sulfate) iron supplementation. Serum ferritin was measured at baseline and 8 or 12 wk. |
1(0,0,0,1) | Details |
| 9328369 | Ahluwalia N, Skikne BS, Savin V, Chonko A: Markers of masked iron deficiency and effectiveness of EPO therapy in chronic renal failure. Am J Kidney Dis. 1997 Oct;30(4):532-41. In patients on rHuEPO replacement with serum ferritin levels greater than 30 microg/L, none of the panel of tests, including serum TfR, reliably detected masked iron deficiency. |
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| 9502420 | Cable EE, Connor JR, Isom HC: Accumulation of iron by primary rat hepatocytes in long-term culture: changes in nuclear shape mediated by non-transferrin-bound forms of iron. Am J Pathol. 1998 Mar;152(3):781-92. Hepatocytes in long-term DMSO culture can be iron loaded by exposure to non-transferrin-bound iron (NTBI) in the form of ferrous sulfate (FeSO4), ferric nitrilotriacetate, or trimethylhexanoyl (TMH)-ferrocene. The cellular deposition of iron was different in hepatocytes exposed to TMH-ferrocene compared with those exposed to FeSO4; exposure to TMH-ferrocene resulted in the presence of more ferritin cores within lysosomes than were seen with FeSO4. |
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| 3920380 | Caballero B, Solomons NW, Batres R, Torun B: Homeostatic mechanisms in the utilization of exogenous iron in children recovering from severe malnutrition. J Pediatr Gastroenterol Nutr. 1985 Feb;4(1):97-102. Twenty-six preschool children were divided in two groups according to their initial iron reserves, as estimated from serum ferritin concentration, using a cutoff criterion of 30 ng/ml. All children received an adequate therapeutic diet and 60 mg iron daily as ferrous sulfate. |
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| 8286880 | Brigham DE, Beard JL, Krimmel RS, Kenney WL: Changes in iron status during competitive season in female collegiate swimmers. Nutrition. 1993 Sep-Oct;9(5):418-22. On entry into the study, 17 of the swimmers had depleted iron stores (plasma ferritin < 12 micrograms/L) and 5 were anemic (Hb < 120 g/L). |
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| 3367745 | Risser WL, Lee EJ, Poindexter HB, West MS, Pivarnik JM, Risser JM, Hickson JF: Iron deficiency in female athletes: its prevalence and impact on performance. Med Sci Sports Exerc. 1988 Apr;20(2):116-21. All subjects had determinations of hemoglobin, ferritin, and transferrin saturation. |
2(0,0,0,2) | Details |
| 12667611 | Lindsay S, Brosnahan D, Lowery TJ Jr, Crawford K, Watt GD: Kinetic studies of iron deposition in horse spleen ferritin using O2 as oxidant. Biochim Biophys Acta. 2003 Apr 7;1621(1):57-66. |
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| 7492158 | Stevens D, Nelson A: The effect of iron in formula milk after 6 months of age. Arch Dis Child. 1995 Sep;73(3):216-20. Very few infants developed iron deficiency anaemia in either group but there was a tendency for serum ferritin levels to fall between 6 and 18 months of age in both groups. |
1(0,0,0,1) | Details |
| 3759957 | Bakker GR, Boyer RF: incorporation into apoferritin. J Biol Chem. 1986 Oct 5;261(28):13182-5. Ferritins with varying loads of iron have the same ferroxidase activity level. |
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| 17532714 | Lazzari F, Carrara M: Overview of clinical trials in the treatment of iron deficiency with iron-acetyl-aspartylated casein. Clin Drug Investig. 2005;25(11):679-89. therapy is necessary in a wide variety of clinical situations, and new formulations with improved tolerability and efficacy would be a welcome alternative to ferrous sulfate. In healthy volunteers, Fe-ASP proved to be an efficient vehicle for providing iron with high bioavailability and more rapid and persistent increases in serum iron levels than ferritin. |
1(0,0,0,1) | Details |
| 15958324 | Li YQ, Mai LS, Chang HL, Yu BJ, Huang ZL: [Efficacy of complex Hongyibuxue oral solution and ferrous sulfate for iron deficiency anemia]. Di Yi Jun Yi Da Xue Xue Bao. 2005 Jun;25(6):732-3. RESULTS: Hemoglobin, serum iron and serum ferritin in the test group rose faster than those in control group (P <0.05). |
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| 1764677 | Renaud DL, Nichol H, Locke M: The visualization of apoferritin in the secretory pathway of vertebrate liver cells. J Submicrosc Cytol Pathol. 1991 Oct;23(4):501-7. We conclude that ferritin occurs in the endoplasmic reticulum and could be secreted, allowing the liver to be a source of serum ferritin. |
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| 18363581 | Maghsudlu M, Nasizadeh S, Toogeh GR, Zandieh T, Parandoush S, Rezayani M: Short-term ferrous sulfate supplementation in female blood donors. Transfusion. 2008 Jun;48(6):1192-7. Epub 2008 Mar 17. Their hemoglobin (Hb) concentration, hematocrit (Hct), serum ferritin, total iron-binding capacity (TIBC), and percent saturation of the TIBC were tested throughout the course of the study. |
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| 17572803 | Dos Santos MM, Nogueira Ndo N, Diniz Ada S: [Effectiveness of different iron supplementation strategies on hemoglobin and ferritin levels among schoolchildren in Teresina, Piaui State, Brazil]. Cad Saude Publica. 2007 Jul;23(7):1547-52. This study evaluated the effectiveness of supplementation with ferrous sulfate and iron bis-glycinate chelate on hemoglobin and serum ferritin levels among schoolchildren (7-11 years) of both sexes. |
82(1,1,1,2) | Details |
| 15377970 | Pitsis GC, Fallon KE, Fallon SK, Fazakerley R: Response of soluble transferrin receptor and iron-related parameters to iron supplementation in elite, iron-depleted, nonanemic female athletes. Clin J Sport Med. 2004 Sep;14(5):300-4. OBJECTIVES: To assess the effect of short-term iron supplementation on soluble transferrin receptor (sTfR) and the soluble transferrin receptor/log ferritin ratio in a group of elite, iron-depleted, nonanemic female athletes and to assess the relationship between soluble transferrin receptor and serum ferritin in a group of elite, iron-depleted female athletes. INTERVENTION: Ingestion of 1 iron tablet (325 mg dried ferrous sulfate, equivalent to 105 mg elemental iron) plus one 500-mg tablet of each morning for 60 days. |
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| 3167502 | Mahlamaki E, Mahlamaki S: Iron deficiency in adolescent female dancers. Br J Sports Med. 1988 Jun;22(2):55-6. The concentrations of fasting blood haemoglobin, serum iron, serum transferrin and serum ferritin were determined. |
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| 16478282 | Proulx AK, Reddy MB: bioavailability of hemoglobin from soy root nodules using a Caco-2 cell culture model. J Agric Food Chem. 2006 Feb 22;54(4):1518-22. Our objective was to test the effectiveness of soy root nodule (SRN) and purified soy hemoglobin (LHb) in improving iron bioavailability using an in vitro Caco-2 cell model, with ferritin response as the bioavailability index. We assessed bioavailability of iron from LHb (either partially purified (LHbA) or purified (LHbD)) with and without food matrix and compared it with that from bovine hemoglobin (BHb), ferrous sulfate (FeSO4), or SRN. |
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| 3341317 | Rowland TW, Deisroth MB, Green GM, Kelleher JF: The effect of iron therapy on the exercise capacity of nonanemic iron-deficient adolescent runners. Am J Dis Child. 1988 Feb;142(2):165-9. In 14 iron-deficient (serum ferritin level, less than 20 micrograms/L [less than 20 ng/L]) nonanemic runners, hematologic and treadmill running values were followed up during a competitive season. Following a four-week control period, runners were treated for one month in a double-blind protocol with ferrous sulfate (975 mg/d) or placebo. |
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| 2241732 | Lukaski HC, Hall CB, Nielsen FH: Thermogenesis and thermoregulatory function of iron-deficient women without anemia. Aviat Space Environ Med. 1990 Oct;61(10):913-20. Physiological responses at 16 degrees C were studied in 11 women, age 28 +/- 2 (mean +/- S.E.) years and 26 +/- 2% fat, after their body iron stores were depleted by diet (5.0 mg iron x 2,000 kcal-1 x d-1), phlebotomy and menstruation for about 80 d and were repleted by diet (13.7 mg iron x 2,000 kcal-1 x d-1) for about 100 d, including daily iron supplementation (50 mg of iron as ferrous sulfate) for the last 14 d of repletion. depletion was characterized by a decline (p less than 0.05) in hemoglobin (12.0 +/- 0.2 g x dl-1), ferritin (5.5 +/- 0.5 ng x ml-1) and body iron balance (-9.1 +/- 2.6 mg x 6 d-1). |
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| 3947745 | Gordeuk VR, Brittenham GM, McLaren CE, Hughes MA, Keating LJ: therapy for iron deficiency anemia. . Blood. 1986 Mar;67(3):745-52. Single doses of 1,000 to 10,000 mg of (15 to 150 times the 65 mg of iron in the usual dose of ferrous sulfate) were tolerated by nonanemic volunteers with no evidence of toxicity and only minor gastrointestinal side effects. After 12 weeks anemia was corrected in 29 of 32 patients, and serum ferritin was greater than 12 micrograms/L in 14. |
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| 1361844 | Johnson CA, Rosowski E, Zimmerman SW: A prospective open-label study evaluating the efficacy and adverse reactions of the use of Niferex-150 in ESRD patients receiving EPOGEN. Adv Perit Dial. 1992;8:444-7. Ferrous sulfate is commonly prescribed, however many patients experience adverse gastrointestinal effects. The following laboratory information was recorded: hematocrit, serum iron concentration, percent transferrin saturation, total iron-binding capacity, serum ferritin concentration. |
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| 18937740 | Page EA, Harrison JF, Jaldow EJ, Kopelman M: Impairment of short-term memory associated with low iron stores in a volunteer multidose plateletpheresis donor. Transfus Med. 2008 Oct;18(5):312-4. He was found to have a normal haemoglobin of 157 g L (-1) with normal red blood cell indices, but a low serum ferritin (15 ng mL (-1)) and a low serum iron (8.1 mmol L (-1)). |
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| 9351406 | Eskeland B, Malterud K, Ulvik RJ, Hunskaar S: supplementation in pregnancy: is less enough? A randomized, placebo controlled trial of low dose iron supplementation with and without heme iron. Acta Obstet Gynecol Scand. 1997 Oct;76(9):822-8. The women were tested for red cell indices and iron status markers (s-ferritin, s-iron, Total Binding Capacity and erythrocyte throughout pregnancy and 8 and 24 weeks postpartum. |
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| 15883447 | Hunt JR: Absorption of iron from ferritin. Am J Clin Nutr. 2005 May;81(5):1178-9; author reply 1179-80. |
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| 1227766 | Greengard J: poisoning in children. Clin Toxicol. 1975;8(6):575-97. In this connection breakdown of the mucosal barrier with release of apoferritin and ferritin as a hypotensive mechanism has also been suggested by Smith. And the anion may indeed play the predominant role as demonstrated by the observation of the severe corrosive changes observed when accumulations of ferrous sulfate tablets occur in areas of the stomach or small bowel. |
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| 11688081 | Szarfarc SC, de Cassana LM, Fujimori E, Guerra-Shinohara EM, de Oliveira IM: Relative effectiveness of iron bis-glycinate chelate (Ferrochel) and ferrous sulfate in the control of iron deficiency in pregnant women. Arch Latinoam Nutr. 2001 Mar;51(1 Suppl 1):42-7. The relative effectiveness of daily supplementation of iron deficiency during pregnancy using 15 mg/day of iron from iron-bis-glycinate chelate (71 pregnant women), or 40 mg iron from ferrous sulfate (74 pregnant women) was evaluated by measuring hemoglobin, transferrin saturation and serum ferritin, at the beginning of the study (< 20 weeks of pregnancy) and at 20-30 weeks and 30-40 weeks thereafter. |
31(0,1,1,1) | Details |
| 16469988 | Lonnerdal B, Bryant A: Absorption of iron from recombinant human lactoferrin in young US women. Am J Clin Nutr. 2006 Feb;83(2):305-9. Serum ferritin and iron absorption were inversely correlated in subjects when they received either lactoferrin or ferrous sulfate, which suggested that iron is absorbed from the 2 sources by a similar mechanism. |
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| 15447902 | Davila-Hicks P, Theil EC, Lonnerdal B: in ferritin or in salts (ferrous sulfate) is equally bioavailable in nonanemic women. Am J Clin Nutr. 2004 Oct;80(4):936-40. |
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| 3299394 | Sas G, Scheffer K, Schreiber G, Brauer H, Ceccarelli G: Ferritin versus ferrous sulphate preparations: a controlled study in sideropaenic patients. Pharmatherapeutica. 1986;4(10):673-8. |
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| 6726596 | Wallenburg HC, van Eijk HG: Effect of oral iron supplementation during pregnancy on maternal and fetal iron status. J Perinat Med. 1984;12(1):7-12. Maternal concentrations of hemoglobin, serum iron, serum transferrin and serum ferritin were determined at 16, 28 and 36 weeks of amenorrhea, at delivery, and 6 and 12 weeks post partum. |
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| 19474138 | McClung JP, Karl JP, Cable SJ, Williams KW, Nindl BC, Young AJ, Lieberman HR: Randomized, double-blind, placebo-controlled trial of iron supplementation in female soldiers during military training: effects on iron status, physical performance, and mood. Am J Clin Nutr. 2009 Jul;90(1):124-31. Epub 2009 May 27. DESIGN: In this 8-wk randomized, double-blind, placebo-controlled trial, soldier volunteers (n = 219) were provided with capsules containing either 100 mg ferrous sulfate or a placebo. RESULTS: The BCT course affected iron status: red blood cell distribution width and soluble transferrin receptor were elevated (P < 0.05), and serum ferritin was lowered (P < 0.05) post-BCT. |
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| 11722961 | Zlotkin S, Arthur P, Antwi KY, Yeung G: Treatment of anemia with microencapsulated ferrous plus supplied as sprinkles to complementary (weaning) foods. Am J Clin Nutr. 2001 Dec;74(6):791-5. BACKGROUND: Standard therapy for anemia in infants is ferrous sulfate drops administered 3 times/d. Hemoglobin and serum ferritin concentrations were measured at baseline and at the end of treatment. |
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| 14704299 | Etcheverry P, Miller DD, Glahn RP: A low-molecular-weight factor in human milk whey promotes iron uptake by Caco-2 cells. J Nutr. 2004 Jan;134(1):93-8. Samples were prepared by mixing various combinations of the fractions, bringing the samples to prefractionation weight with minimum essential medium (MEM), and adding iron (10 micro mol/L) as ferrous sulfate. Ferritin formation in the cells was used as an index of iron uptake. |
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| 11377130 | Pineda O, Ashmead HD: Effectiveness of treatment of iron-deficiency anemia in infants and young children with ferrous bis-glycinate chelate. Nutrition. 2001 May;17(5):381-4. Both groups had significant hemoglobin increases (P < 0.001), but only the group treated with ferrous bis-glycinate chelate had significant increases (P < 0.005) in plasma ferritin. |
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| 7608597 | Shinonaga M: [Changes in hematological indices, iron levels and marrow erythroids through autologous blood donation before cardiac surgery--predonation with versus without recombinant human erythropoietin]. Nippon Kyobu Geka Gakkai Zasshi. 1995 Apr;43(4):479-87. A unit of autologous blood (200 ml) was to be donated every 3 or 4 days for 2 weeks. 200mg of ferrous sulfate was given orally every day in 10 patients (the simple donation group), while 200 U/kg of rEPO was given intravenously 3 times a week in combination with oral ferrous sulfate supplementation in 15 patients (the rEPO-treatment group). In the rEPO-treatment group, hematocrit levels remained unchanged and serum ferritin levels decreased significantly (p < 0.02) after the donation; in addition, serum iron levels in the rEPO-treatment group decreased significantly (p < 0.05) than those in the simple donation group during donation. |
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| 4055462 | Rosen GM, Deinard AS, Schwartz S, Smith C, Stephenson B, Grabenstein B: Iron deficiency among incarcerated juvenile delinquents. J Adolesc Health Care. 1985 Nov;6(6):419-23. A population of 163 incarcerated delinquents (126 males and 37 females aged 12-18 years) was studied to determine the prevalence of iron deficiency and to compare hemoglobin (Hgb), mean corpuscular volume (MCV), serum ferritin (SF), and erythrocyte /hemoglobin (EP/Hgb) as predictors of response to iron therapy. |
1(0,0,0,1) | Details |
| 12358889 | El-Agouza I, Abu Shahla A, Sirdah M: The effect of iron deficiency anaemia on the levels of haemoglobin subtypes: possible consequences for clinical diagnosis. Clin Lab Haematol. 2002 Oct;24(5):285-9. Serum ferritin, HbA2, HbF, and HbA1C levels were determined for all microcytic/hypochromic subjects. |
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| 19357222 | Lonnerdal B: Soybean ferritin: implications for iron status of vegetarians. Am J Clin Nutr. 2009 May;89(5):1680S-1685S. Epub 2009 Apr 8. In human subjects, iron from purified soybean ferritin given in a meal was as well absorbed as iron from ferrous sulfate. |
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| 18214015 | Lonnerdal B: The importance and bioavailability of phytoferritin-bound iron in cereals and legume foods. Int J Vitam Nutr Res. 2007 May;77(3):152-7. In human subjects, we found that iron absorption from animal ferritin was similar to that from ferrous sulfate, suggesting that iron is well absorbed from ferritin. |
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| 19292462 | Lukac RJ, Aluru MR, Reddy MB: Quantification of ferritin from staple food crops. J Agric Food Chem. 2009 Mar 25;57(6):2155-61. Ferritin-iron has been shown to be as bioavailable as ferrous sulfate in humans. |
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| 3524335 | Harju E, Lindberg H: does not augment the restoration effect of iron treatment for empty iron stores in patients after gastrointestinal surgery. Am Surg. 1986 Aug;52(8):463-6. The effect of a 6-week combined treatment with ferrous sulfate (80 mg Fe++ three times daily) and (75 mg three times daily) on the empty iron stores in 20 patients after gastrointestinal surgery was examined from changes of serum ferritin. |
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| 18971162 | Lei J, Zhang MQ, Huang CY, Bai L, He ZH: [Effects of and on iron bioavailability in an in vitro digestion/ Caco-2 cell culture model]. Nan Fang Yi Ke Da Xue Xue Bao. 2008 Oct;28(10):1743-7. Ferritin formation in the Caco-2 cells was measured as the indicator of Fe uptake by exposing Caco-2 cells to the digests containing Fe plus or |
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| 18979587 | Shamah-Levy T, Villalpando S, Rivera-Dommarco JA, Mundo-Rosas V, Cuevas-Nasu L, Jimenez-Aguilar A: Ferrous and ferrous sulfate added to a complementary food distributed by the Mexican nutrition program Oportunidades have a comparable efficacy to reduce iron deficiency in toddlers. J Pediatr Gastroenterol Nutr. 2008 Nov;47(5):660-6. In final blood samples, the concentrations of hemoglobin, serum ferritin, and soluble transferrin receptors (sTfR) were determined. |
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| 11074539 | Barton JC, Bottomley SS: Iron deficiency due to excessive therapeutic phlebotomy in hemochromatosis. Am J Hematol. 2000 Nov;65(3):223-6. Levels of transferrin saturation were 10% +/- 5% (1 SD), and serum ferritin concentrations were 8 +/- 3 ng/mL. Ten of the patients were treated with ferrous sulfate, 325 mg daily, for 2-6 weeks when anemia was corrected. |
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| 17035697 | Agarwal R, Rizkala AR, Bastani B, Kaskas MO, Leehey DJ, Besarab A: A randomized controlled trial of oral versus intravenous iron in chronic kidney disease. Am J Nephrol. 2006;26(5):445-54. Epub 2006 Oct 11. METHODS: The participants were randomized to receive either a ferric complex (intravenous iron) 250 mg i.v. weekly x 4 or ferrous sulfate (oral iron) 325 mg t.i.d. x 42 days. Hemoglobin (Hgb), ferritin and transferrin saturation (TSAT) were measured serially, and the Kidney Disease Quality of Life (KDQoL) questionnaire was administered on days 1 and 43. |
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| 19643212 | Messer JG, Kilbarger AK, Erikson KM, Kipp DE: Iron overload alters iron-regulatory genes and proteins, down-regulates osteoblastic phenotype, and is associated with apoptosis in fetal rat calvaria cultures. Bone. 2009 Nov;45(5):972-9. Epub 2009 Jul 28. Cells were incubated with media supplemented with 0-10 microM ferrous sulfate (FeSO (4)) during differentiation (days 6-20). Intracellular iron status was assessed by measuring iron content in cell layers and changes in transferrin receptor (TrfR) and ferritin gene and protein expression. |
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| 12540404 | Zimmermann MB, Zeder C, Chaouki N, Saad A, Torresani T, Hurrell RF: Dual fortification of salt with and microencapsulated iron: a randomized, double-blind, controlled trial in Moroccan schoolchildren. Am J Clin Nutr. 2003 Feb;77(2):425-32. At 40 wk, mean hemoglobin concentrations in the DFS group had increased by 14 g/L (P < 0.01), and serum ferritin, transferrin receptor, and zinc concentrations were significantly better (P < 0.05) in the DFS group than in the iodized salt group. We then formulated a DFS containing 25 micro g /g salt (as iodide) and 1 mg iron/g salt (as ferrous sulfate hydrate encapsulated with partially hydrogenated vegetable oil). |
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| 19403640 | Davidsson L, Sarker SA, Jamil KA, Sultana S, Hurrell R: Regular consumption of a complementary food fortified with and ferrous or ferric is as useful as ferrous sulfate in maintaining hemoglobin concentrations > 105 g/L in young Bangladeshi children. Am J Clin Nutr. 2009 Jun;89(6):1815-20. Epub 2009 Apr 29. RESULTS: Raw data were reformatted, and a "time to event" was calculated that corresponded to reaching the following thresholds: hemoglobin <105 g/L, plasma ferritin <12 microg/L, or plasma C-reactive protein > 10 mg/L at baseline, 4.5 mo, or 9 mo. |
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| 925814 | Lundstrom U, Siimes MA, Dallman PR: At what age does iron supplementation become necessary in low-birth-weight infants?. J Pediatr. 1977 Dec;91(6):878-83. In order to accurately determine when this depletion occurs, we measured the hemoglobin, mean corpuscular volume, serum iron/iron-binding capacity, and serum ferritin in 117 low-birth-weight infants (1,000 to 2,000 gm) from 0.5 until 6 months of age. All infants received banked breast milk in the hospital and breast milk or cow milk formula later; those with odd birth dates received 2 mg iron as ferrous sulfate/kg/day starting at 0.5 months; those with even birth dates received no additional iron unless they developed anemia. |
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| 12182902 | Regan RF, Kumar N, Gao F, Guo Y: Ferritin induction protects cortical astrocytes from heme-mediated oxidative injury. Neuroscience. 2002;113(4):985-94. Incubation with low micromolar concentrations of hemin, hemoglobin, or ferrous sulfate increased ferritin expression, as detected on immunoblots stained with a polyclonal antibody that was raised against horse spleen ferritin. |
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| 18755051 | Jin F, Frohman C, Thannhauser TW, Welch RM, Glahn RP: Effects of and tannic acid on iron bioavailability from reconstituted ferritin measured by an in vitro digestion-Caco-2 cell model. Br J Nutr. 2009 Apr;101(7):972-81. Epub 2008 Aug 28. In the presence of AA (Fe:AA molar ratio of 1:20), significantly more Fe was absorbed from FeSO4 (about 303 %), HSF (about 454 %) and P-HSF (about 371 %) when compared with ferrous sulfate or ferritin without AA. |
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| 16400057 | Lonnerdal B, Bryant A, Liu X, Theil EC: absorption from soybean ferritin in nonanemic women. Am J Clin Nutr. 2006 Jan;83(1):103-7. |
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| 7872321 | Wingard RL, Parker RA, Ismail N, Hakim RM: Efficacy of oral iron therapy in patients receiving recombinant human erythropoietin. Am J Kidney Dis. 1995 Mar;25(3):433-9. The efficacy of oral iron is variable in these patients, and many require the use of intravenous iron dextran to maintain adequate iron levels, defined as transferrin saturation greater than 20%, serum ferritin greater than 100 ng/mL, and serum iron greater than 80 micrograms/dL. These four preparations included Chromagen (ferrous Savage Laboratories, Melville, NY), Feosol (ferrous sulfate; SmithKline Beecham, Inc, Pittsburgh, PA), Niferex (polysaccharide; Central Pharmaceuticals, Inc, Seymour, IN), or Tabron (ferrous Parke-Davis, Morris Plains, NJ). |
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| 19639462 | Nappi C, Tommaselli GA, Morra I, Massaro M, Formisano C, Di Carlo C: Efficacy and tolerability of oral bovine lactoferrin compared to ferrous sulfate in pregnant women with iron deficiency anemia: a prospective controlled randomized study. Acta Obstet Gynecol Scand. 2009;88(9):1031-5. METHODS: After 30 days, we evaluated hemoglobin (Hb), serum ferritin, serum iron and total iron- binding capacity (TIBC) values. |
3(0,0,0,3) | Details |
| 8855856 | Bruner AB, Joffe A, Duggan AK, Casella JF, Brandt J: Randomised study of cognitive effects of iron supplementation in non-anaemic iron-deficient adolescent girls. Lancet. 1996 Oct 12;348(9033):992-6. METHODS: 716 girls who enrolled at four Baltimore high schools were screened for non-anaemic iron deficiency (serum ferritin < or = 12 micrograms/L with normal haemoglobin). 98 (13.7%) girls had non-anaemic iron deficiency of whom 81 were enrolled in the trial. |
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| 1896246 | Woodhead JC, Drulis JM, Nelson SE, Janghorbani M, Fomon SJ: Gender-related differences in iron absorption by preadolescent children. Pediatr Res. 1991 May;29(5):435-9. Study A: A precisely determined quantity of ferrous sulfate enriched with the stable isotope 58Fe was given without food to 15 boys and 15 girls (Tanner stage 1) after an overnight fast and was immediately followed by a dose of 70 mg of 58Fe enrichment of the erythrocytes was determined by inductively coupled plasma mass spectrometry at baseline and 14 and 42 d after administration of the 58Fe dose. The difference was significant (analysis of covariance with serum ferritin as covariate, p = 0.035). |
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| 6665652 | Dommisse J, Bell DJ, Du Toit ED, Midgley V, Cohen M: -storage deficiency and iron supplementation in pregnancy. S Afr Med J. 1983 Dec 24;64(27):1047-51. Eighteen per cent had both reduced serum ferritin and raised serum transferrin values without significant anaemia, suggesting covert iron-storage deficiency. |
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| 8169656 | Lawless JW, Latham MC, Stephenson LS, Kinoti SN, Pertet AM: supplementation improves appetite and growth in anemic Kenyan primary school children. J Nutr. 1994 May;124(5):645-54. Sustained-release ferrous sulfate (150 mg) or placebo tablets were provided daily at school for 14 wk. Prior to tablet administration, baseline anthropometry, iron nutritional status (hemoglobin and serum ferritin), parasitic infections and clinical indicators of morbidity were measured. |
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| 8055848 | Cardoso MA, Ferreira MU, Camargo LM, Szarfarc SC: Anaemia, iron deficiency and malaria in a rural community in Brazilian Amazon. Eur J Clin Nutr. 1994 May;48(5):326-32. Depleted iron stores [serum ferritin (SF) < 12 micrograms/l] were detected in 10.0% subjects in survey A, 10.1% in B but in only 8.8% subjects in survey C. |
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| 18928998 | Seid MH, Derman RJ, Baker JB, Banach W, Goldberg C, Rogers R: Ferric carboxymaltose injection in the treatment of postpartum iron deficiency anemia: a randomized controlled clinical trial. Am J Obstet Gynecol. 2008 Oct;199(4):435.e1-7. OBJECTIVE: The objective of the study was to evaluate the efficacy, safety, and tolerability of intravenous ferric carboxymaltose, compared with oral ferrous sulfate in women with postpartum anemia. RESULTS: Ferric carboxymaltose-treated subjects were significantly more likely to: (1) achieve a hemoglobin greater than 12 g/dL in a shorter time period with a sustained hemoglobin greater than 12 g/dL at day 42, (2) achieve hemoglobin rise 3 g/dL or greater more quickly, and (3) attain higher serum transferrin saturation and ferritin levels. |
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| 8417806 | Nagel RL, Vichinsky E, Shah M, Johnson R, Spadacino E, Fabry ME, Mangahas L, Abel R, Stamatoyannopoulos G: F reticulocyte response in sickle cell anemia treated with recombinant human erythropoietin: a double-blind study. Blood. 1993 Jan 1;81(1):9-14. We found that none of the five patients in the first group responded to rHuEPO, and two of them became iron deficient, as judged by a significant decrease in ferritin. |
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| 11201567 | Pearson EG, Andreasen CB: Effect of oral administration of excessive iron in adult ponies. J Am Vet Med Assoc. 2001 Feb 1;218(3):400-4. PROCEDURE: 4 ponies received 50 mg of iron/kg (22.7 mg/lb) of body weight each day by oral administration of ferrous sulfate, which contained 20% elemental iron; 2 ponies received only the carrier (applesauce). RESULTS: Hepatic iron concentrations, serum iron concentrations, percentage saturation of transferrin, and serum ferritin concentrations were increased, compared with baseline and control concentrations, by week 8. |
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| 19405553 | Lyseng-Williamson KA, Keating GM: Ferric carboxymaltose: a review of its use in iron-deficiency anaemia. . Drugs. 2009;69(6):739-56. doi: 10.2165/00003495-200969060-00007. Ferric carboxymaltose was at least as effective as ferrous sulfate with regard to endpoints related to serum ferritin levels, transferrin saturation and HR-QOL. |
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| 10682464 | Wu Y, Weng L, Wu L: [Clinical experience with iron supplementation in pregnancy] . Zhonghua Fu Chan Ke Za Zhi. 1998 Apr;33(4):206-8. As for the anemia women, compared the serum ferritin concentration, materna treatment had significantly higher levels than that at admission (P < 0.05), and also higher than that in the ferrous sulfate or ferroids tratment groups (P < 0.05). |
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| 8197526 | Hernandez Lamas MC, Lopez Perez-Lanzac JC, Prat Arrojo I, Sanchez Gordo F, Arleth Christensen E, Sanchez Font E: [Determination of serum ferritin: ideas for avoiding induced ferropenia in blood donors]. Sangre. 1994 Feb;39(1):9-14. |
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| 10710409 | Hinton PS, Giordano C, Brownlie T, Haas JD: supplementation improves endurance after training in iron-depleted, nonanemic women. J Appl Physiol. 2000 Mar;88(3):1103-11. Forty-two iron-depleted (serum ferritin <16 microg/l), nonanemic (Hb > 12 g/dl) women (18-33 yr old) received 100 mg of ferrous sulfate (S) or placebo (P) per day for 6 wk in a randomized, double-blind trial. |
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| 11983821 | Murray-Kolb LE, Takaiwa F, Goto F, Yoshihara T, Theil EC, Beard JL: Transgenic rice is a source of iron for iron-depleted rats. J Nutr. 2002 May;132(5):957-60. Because ferritin is used as a natural source of iron in the early development of humans, other animals and plants, the bioavailability of iron in rice seeds, provided in amounts equal to ferrous sulfate, and in transgenic rice with ferritin was tested in iron-deficient rats. |
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| 12481145 | Trivedi HS, Brooks BJ: Erythropoietin therapy in pre-dialysis patients with chronic renal failure: lack of need for parenteral iron. Am J Nephrol. 2003 Mar-Apr;23(2):78-85. BACKGROUND: During erythropoietin therapy, scant information exists regarding the optimal target percent saturation of transferrin (TSAT), ferritin and the mode and amount of iron supplementation in pre-dialysis patients with anemia due to chronic kidney disease (CKD). |
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| 12097660 | Donangelo CM, Woodhouse LR, King SM, Viteri FE, King JC: Supplemental zinc lowers measures of iron status in young women with low iron reserves. J Nutr. 2002 Jul;132(7):1860-4. The effect of zinc supplementation (22 mg Zn/d as zinc or of iron supplementation (100 mg Fe/d as ferrous sulfate) for 6 wk on iron and zinc metabolism and absorption was evaluated in young women with low iron reserves. Young adult women (ages 20-28 y), nonanemic but with low iron stores (plasma ferritin < 20 microg/L), participated in the 70-d study. |
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| 17435611 | Saha L, Pandhi P, Gopalan S, Malhotra S, Saha PK: Comparison of efficacy, tolerability, and cost of iron polymaltose complex with ferrous sulphate in the treatment of iron deficiency anemia in pregnant women. MedGenMed. 2007 Jan 2;9(1):1. METHODS: One hundred pregnant women aged 20-40 years at 14 to 27 weeks' gestation, with hemoglobin (Hb) < 9 g/dL, and serum ferritin < 12 mcg/L, were classified into 2 groups. |
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| 1501568 | Klingshirn LA, Pate RR, Bourque SP, Davis JM, Sargent RG: Effect of iron supplementation on endurance capacity in iron-depleted female runners. Med Sci Sports Exerc. 1992 Jul;24(7):819-24. Eighteen iron-depleted (serum ferritin less than 20 ng.ml-1, hemoglobin greater than or equal to 12 g.dl-1) women (22-39 yr) performed a VO2max test and an endurance run to exhaustion. |
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| 14765861 | Sutton PM, Cresswell T, Livesey JP, Speed K, Bagga T: Treatment of anaemia after joint replacement. J Bone Joint Surg Br. 2004 Jan;86(1):31-3. The level of serum ferritin should be monitored at preoperative assessment. |
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| 12096389 | Sotelo-Cruz N, Gomez-Rivera N, Ferra-Fragoso S, Pereyda-Galaz DE: [Treatment of iron deficiency in preschool children with a weekly dose of ferrous sulfate]. Gac Med Mex. 2002 May-Jun;138(3):225-30. After the treatment all the patients improved haemoglobin, ferritin an iron concentrations (p = 0.001). |
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| 3366024 | Harju E: Body iron stores in patients subjected to surgery of the large bowel. Dis Colon Rectum. 1988 Jan;31(1):42-5. stores as estimated by serum ferritin concentration were studied in 40 patients subjected to colon surgery in reference to postoperative complications and restoration of iron stores, as well as to dietary and supplementary iron. In 12 patients with empty iron stores the effects of ferrous sulfate (80 mg Fe++) three times daily for six weeks were studied. |
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| 2757026 | Van Wyck DB: management during recombinant human erythropoietin therapy. Am J Kidney Dis. 1989 Aug;14(2 Suppl 1):9-13. A plasma ferritin level of less than 30 ng/mL or a transferrin saturation level of less than 20% confirms the diagnosis of iron deficiency. In all patients except those with transfusional iron overload, prophylactic supplementation with ferrous sulfate (325 mg up to three times daily) is recommended. |
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| 8988907 | Rosado JL, Lopez P, Munoz E, Martinez H, Allen LH: supplementation reduced morbidity, but neither zinc nor iron supplementation affected growth or body composition of Mexican preschoolers. Am J Clin Nutr. 1997 Jan;65(1):13-9. In a double-blind, randomized community trial 219 Mexican preschoolers were supplemented with either 20 mg Zn as zinc 20 mg Fe as ferrous sulfate, 20 mg Zn + 20 mg Fe, or a placebo. After 12 mo, plasma zinc increased significantly in the two zinc-treated groups, and plasma ferritin was significantly higher in the two iron-treated groups. |
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| 8659499 | Silverberg DS, Iaina A, Peer G, Kaplan E, Levi BA, Frank N, Steinbruch S, Blum M: Intravenous iron supplementation for the treatment of the anemia of moderate to severe chronic renal failure patients not receiving dialysis. Am J Kidney Dis. 1996 Feb;27(2):234-8. This could be achieved by increasing the plasma ferritin levels to 200 to 400 microns/L and/or increasing the iron saturation to 25% to 35%. |
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| 9297428 | Javier Manchon G, Natal Pujol A, Coroleu Lletget W, Zuasnabar Cotro A, Badia Barnusell J, Junca Piera J, Bel Comos J, Sabado Alvarez C, Prats Vinas J: [Randomized multi-center trial of the administration of erythropoietin in anemia of prematurity]. An Esp Pediatr. 1997 Jun;46(6):587-92. Those infants ascribed to the treatment group received 200 U/kg of body weight of rH-EPO subcutaneously once a day, three days a week for 4 weeks together with oral supplements of ferrous sulfate at a dosage of 4 mg/kg/day. Erythropoietin and ferritin were determined at randomization and at 60 days of age. |
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| 2912000 | Yadrick MK, Kenney MA, Winterfeldt EA: and zinc status: response to supplementation with zinc or zinc and iron in adult females. Am J Clin Nutr. 1989 Jan;49(1):145-50. Group Z received 50 mg Zn/d as Zn group F-Z received 50 mg Fe as ferrous sulfate monohydrate in addition to the Zn. For Group Z, serum ferritin, hematocrit, and erythrocyte Cu,Zn-superoxide dismutase (ESOD) were significantly lower (p less than 0.05) after 10 wk supplementation compared with pretreatment levels. |
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| 3418418 | Taylor P, Martinez-Torres C, Leets I, Ramirez J, Garcia-Casal MN, Layrisse M: Relationships among iron absorption, percent saturation of plasma transferrin and serum ferritin concentration in humans. J Nutr. 1988 Sep;118(9):1110-5. The percent absorption of iron from four dietary sources was compared in 2018 human subjects with three indicators of iron status, serum ferritin concentration, percent saturation of plasma transferrin and iron absorption from a reference dose of ferrous sulfate. |
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| 2799004 | Reboani MC, Cirillo R, Franzone JS: [Histologic evaluation of gastric tolerability in rats of ferritin compared with ferrous sulfate]. Riv Eur Sci Med Farmacol. 1989 Apr;11(2):183-8. |
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| 12887843 | Ahmed P, Mahmood A, Aziz S, Azim W: Comparison of response between food supplemented with powdered iron and iron in syrup form for iron deficiency anemia. J Coll Physicians Surg Pak. 2003 Jul;13(7):402-4. Diagnosis was based on history, physical examination, complete blood counts (CBC) and serum ferritin levels. |
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| 10709883 | Choe YH, Lee JE, Kim SK: Effect of helicobacter pylori eradication on sideropenic refractory anaemia in adolescent girls with Helicobacter pylori infection. Acta Paediatr. 2000 Feb;89(2):154-7. Thirteen patients with confirmed H. pylori infection were given a 2-wk course of triple therapy and 6 wk of oral ferrous sulfate. We compared the mean levels of haemoglobin and serum ferritin among the "initial sample" (the time when the sampling was done before treatment with oral iron), "before eradication" (the time prior to triple therapy for eradication after subjects had been given oral iron for 3 mo) and "after eradication" (the time when the follow-up endoscopy was performed) data in 11 subjects in whom H. pylori infection was eradicated. |
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| 18165304 | Boughammoura A, Matzanke BF, Bottger L, Reverchon S, Lesuisse E, Expert D, Franza T: Differential role of ferritins in iron metabolism and virulence of the plant-pathogenic bacterium Erwinia chrysanthemi 3937. J Bacteriol. 2008 Mar;190(5):1518-30. Epub 2007 Dec 28. |
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| 10898136 | Willis A, Hyland P, Lamey PJ: Response to replacement iron therapy in sideropenic individuals with recrudescent herpes labialis. Eur J Clin Microbiol Infect Dis. 2000 May;19(5):355-7. This study investigated the effects of iron replacement on the incidence of recurrent herpes labialis and serum ferritin levels in patients with sideropenia. |
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| 2709674 | Van Wyck DB, Stivelman JC, Ruiz J, Kirlin LF, Katz MA, Ogden DA: status in patients receiving erythropoietin for dialysis-associated anemia. Kidney Int. 1989 Feb;35(2):712-6. We calculated projected iron needed for new hemoglobin synthesis from the difference between initial and target hemoglobin concentrations, initial iron reserves available from initial serum ferritin levels, and net projected surplus or deficit from the difference between needs and reserves. During acute rHuEPO therapy net body iron balance remained neutral in patients receiving no iron supplements and increased 5 mg/kg in patients prescribed oral ferrous sulfate. |
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| 19652922 | Mozaffari-Khosravi H, Noori-Shadkam M, Fatehi F, Naghiaee Y: Once Weekly Low-dose Supplementation Effectively Improved Status in Adolescent Girls. Biol Trace Elem Res. 2009 Aug 4. After 16 weeks of intervention, mean of hemoglobin and serum ferritin improved significantly in ISG compared to IUG. The ISG received 150 mg ferrous sulfate once weekly for 16 weeks, whereas the IUG received nothing. |
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| 15623834 | Perez-Exposito AB, Villalpando S, Rivera JA, Griffin IJ, Abrams SA: Ferrous sulfate is more bioavailable among preschoolers than other forms of iron in a milk-based weaning food distributed by PROGRESA, a national program in Mexico. J Nutr. 2005 Jan;135(1):64-9. The absorption of log-(58) Fe given with the iron source correlated with serum ferritin (s-ferritin) concentration (n = 13, r = 0.63, P = 0.01) and log-(57) Fe absorption (reference dose) (n = 14, r = -0.52, P = 0.02). |
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| 11328574 | Wood EM, Miller JP: Low ferritin levels indicate the need for iron supplementation: strategy to minimize iron depletion in regular blood donors. Transfus Med. 2001 Feb;11(1):59-60. |
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| 19635169 | Barraclough KA, Noble E, Leary D, Brown F, Hawley CM, Campbell SB, Isbel NM, Mudge DW, van Eps CL, Sturtevant JM, Johnson DW: Rationale and design of the oral HEMe iron polypeptide Against Treatment with Oral Controlled Release Tablets trial for the correction of anaemia in peritoneal dialysis patients (HEMATOCRIT trial). BMC Nephrol. 2009 Jul 28;10:20. Secondary outcome measures will include serum ferritin concentration, haemoglobin level, DPO dosage, Key's index (DPO dosage divided by haemoglobin concentration), and occurrence of adverse events (especially gastrointestinal adverse events). |
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| 8819662 | Rani NV, Pandey J, Das B, Shruti, Talib VH, Singh K, Bagati A: Pregnancy associated anemia and iron: a pilot study. Indian J Pathol Microbiol. 1995 Jul;38(3):293-7. TIBC and ferritin levels was better with Code A. |
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| 11509470 | Lee SC, Park SW, Kim DK, Lee SH, Hong KP: supplementation inhibits cough associated with ACE inhibitors. . Hypertension. 2001 Aug;38(2):166-70. After a 2-week observation period, they were randomized to a daily morning dose of either 256-mg ferrous sulfate as a tablet or placebo for a treatment period of 4 weeks. Changes in blood cell count and serum iron and ferritin concentration between the 2 periods were evaluated. |
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| 11451725 | Ahmed F, Khan MR, Jackson AA: Concomitant supplemental enhances the response to weekly supplemental iron and in anemic teenagers in urban Bangladesh. Am J Clin Nutr. 2001 Jul;74(1):108-15. The supplements contained 2.42 mg as 120 mg elemental Fe as ferrous sulfate, and 3.5 mg There was a significantly greater increase in hemoglobin after iron + + than after iron + but the additional effect disappeared after adjustment for baseline hemoglobin, serum and ferritin and the number of supplements taken. |
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| 19203773 | Seck BC, Jackson RT: Providing iron/ tablets free of charge improves compliance in pregnant women in Senegal. Trans R Soc Trop Med Hyg. 2009 May;103(5):485-92. Epub 2009 Feb 8. Hemoglobin, erythrocyte and serum ferritin were measured at baseline and follow-up. |
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| 12032466 | Podesta A, Parodi E, Dottori V, Crivellari R, Passerone GC: Epoetin alpha in elective coronary and valve surgery in Jehovah's Witnesses patients. Minerva Cardioangiol. 2002 Apr;50(2):125-31. Hematochemical levels (hemoglobin, free hemoglobin, hematocrit, ferritin, transferrin, haptoglobin, reticulocytes, iron levels) were monitored from admission to Day Hospital to discharge. |
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| 14615726 | Friel JK, Aziz K, Andrews WL, Harding SV, Courage ML, Adams RJ: A double-masked, randomized control trial of iron supplementation in early infancy in healthy term breast-fed infants. J Pediatr. 2003 Nov;143(5):582-6. STUDY DESIGN: Term breast-fed infants (n=77) were randomly selected to receive either 7.5 mg per day of elemental iron as ferrous sulfate or placebo from 1 to 6 months of age. Complete blood count and ferritin, red cell superoxide dismutase, catalase, plasma ferric reducing antioxidant power, and zinc and levels were analyzed at 1, 3.5, 6, and 12 months of age. |
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| 471141 | Parker PA, Izard MW, Maher JF: Therapy of iron deficiency anemia in patients on maintenance dialysis. Nephron. 1979;23(4):181-6. The serum ferritin assay provides a simple and reliable method to demonstrate iron repletion, and oral ferrous sulfate is the preferred method of iron repletion in compliant patients. |
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| 18499399 | Mimura EC, Bregano JW, Dichi JB, Gregorio EP, Dichi I: Comparison of ferrous sulfate and ferrous glycinate chelate for the treatment of iron deficiency anemia in gastrectomized patients. Nutrition. 2008 Jul-Aug;24(7-8):663-8. Epub 2008 May 21. In addition, ferritin levels increased above 20 microg/L at the end of the study in seven patients using ferrous sulfate in contrast to one patient using ferrous glycinate. |
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| 16263988 | Konofal E, Cortese S, Lecendreux M, Arnulf I, Mouren MC: Effectiveness of iron supplementation in a young child with attention-deficit/hyperactivity disorder. Pediatrics. 2005 Nov;116(5):e732-4. After 8 months of treatment with Tardyferon (ferrous sulfate, 80 mg/day), his serum ferritin increased to 102 ng/mL. |
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| 6888945 | Weippl G: [The significance of serum ferritin determination for the evaluation of preventive iron treatment of anemia in premature infants]. Padiatr Padol. 1983;18(3):239-42. |
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| 17698317 | Sundaram RC, Selvaraj N, Vijayan G, Bobby Z, Hamide A, Rattina Dasse N: Increased plasma malondialdehyde and in iron deficiency anemia: effect of treatment. Biomed Pharmacother. 2007 Dec;61(10):682-5. Epub 2007 Jul 23. Plasma lipid peroxides, fasting glucose, iron, ferritin and hemoglobin were analyzed in both the groups. |
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| 2910045 | Cromer BA, Steinberg K, Gardner L, Thornton D, Shannon B: Psychosocial determinants of compliance in adolescents with iron deficiency. Am J Dis Child. 1989 Jan;143(1):55-8. Home pill counts were highly correlated with the other methods of measuring compliance, ie, change in serum ferritin level and urinary assay for tracer |
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| 16835600 | Hinton PS, Sinclair LM: supplementation maintains ventilatory threshold and improves energetic efficiency in iron-deficient nonanemic athletes. Eur J Clin Nutr. 2007 Jan;61(1):30-9. Epub 2006 Jul 12. SUBJECTS: Twenty iron-deficient (serum ferritin, sFer <16 microg/l; serum transferrin receptor, sTfR> 8.0 mg/l; or sTfR/log sFer index > 4.5), nonanemic (hemoglobin, Hb> 120 g/l, women; > 130 g/l, men) men and women (18-41 years) were recruited via fliers and newspaper advertisements; 20 of 31 eligible subjects participated. INTERVENTIONS: A 30 mg measure of elemental iron as ferrous sulfate or placebo daily for 6 weeks. |
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| 18586646 | Rim H, Kim S, Sim B, Gang H, Kim H, Kim Y, Kim R, Yang M, Kim S: Effect of iron fortification of nursery complementary food on iron status of infants in the DPRKorea. Asia Pac J Clin Nutr. 2008;17(2):264-9. The Fe group received rice porridge fortified with 10 mg of iron (as ferrous sulfate) per day, added to the water in which the rice was cooked and the placebo group non-fortified cereal for 6 months. After which, the hemoglobin (Hb), serum ferritin (SF) and packed cell volume (PCV) were measured and it was found that the proportion of children with anemia (Hb <110 g/L) was lower (24.3% v 48.1% p <0.01), the Hb levels (117.6 g/L v 109.8 g/L p <0.001) and serum ferritin were higher (40.7 v 26.8 mcg/L p <0.001); and iron deficiency anemia (Hb <110 g/L, SF <12 mcg/L) was lower in the Fe group (3% v 22% p <0.001) when compared to the placebo group. |
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| 9566993 | Borigato EV, Martinez FE: nutritional status is improved in Brazilian preterm infants fed food cooked in iron pots. J Nutr. 1998 May;128(5):855-9. Differences included hemoglobin (116 +/- 16 vs. 103 +/- 20 g/L, P = 0.02), hematocrit (0.35 +/- 0.04 vs. 0.31 +/- 0.05, P = 0.005), mean corpuscular volume (72.1 +/- 10.4 vs. 62.7 +/- 11.1 fL, P = 0.005), free erythrocyte (0.78 +/- 0.60 vs. 1.46 +/- 0.94 mol/L, P = 0.006) and serum ferritin (median 5 vs. 0 g/L, P = 0.001). |
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| 2396165 | Bofill C, Salas J, Vernis M, Surroca RM, Joven J: [Evolution of autotransfusion: effect of a diet with and without the ingestion of iron]. Sangre. 1990 Jun;35(3):179-83. The A group (n = 41) was on dietotherapy program associated with a supplement of ferrous sulfate and the B group (n = 35) on dietary intervention only. Serum ferritin levels were measured in the B group patients previous to the autotransfusion and before the surgical intervention. |
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| 8052789 | Morais MB, Ferrari AA, Fisberg M: Effect of oral iron therapy on physical growth. Rev Paul Med. 1993 Nov-Dec;111(6):439-44. In order to evaluate the effects of iron therapy on weight and height, we studied 65 children with a mean age of 32 months who were assigned to oral iron therapy with 4-5 mg/kg/day of elemental iron as ferrous sulfate or ferric polymaltose for 8 weeks. Statistically significant increases in hemoglobin, serum iron and transferrin levels and in transferrin saturation and ferritin levels were observed. |
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| 2733574 | Newhouse IJ, Clement DB, Taunton JE, McKenzie DC: The effects of prelatent/latent iron deficiency on physical work capacity. Med Sci Sports Exerc. 1989 Jun;21(3):263-8. In order to examine the effects of mild iron deficiency on physical work capacity, 40 prelatent iron-deficient female endurance runners were studied before and after 8 wk of supplementation with either oral iron (320 mg ferrous sulfate) or a matching placebo. Serum ferritin values rose from a mean of 12.4 +/- 4.5 to 37.7 +/- 19.7 ng.ml-1 for the experimental group and from 12.2 +/- 4.3 to 17.2 +/- 8.9 ng.ml-1 for the controls (P = 0.0025), whereas hemoglobin levels remained fairly constant for both groups (P = 0.6). |
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| 15333727 | Sungthong R, Mo-suwan L, Chongsuvivatwong V, Geater AF: Once-weekly and 5-days a week iron supplementation differentially affect cognitive function but not school performance in Thai children. J Nutr. 2004 Sep;134(9):2349-54. Ferrous sulfate (300 mg) or placebo tablets were given under direct observation by the researcher for 16 wk. The increases in hemoglobin concentration were comparable in the weekly and daily iron supplementation groups but serum ferritin increased more in the children supplemented daily. |
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| 19342511 | Khomenko T, Szabo S, Deng X, Ishikawa H, Anderson GJ, McLaren GD: Role of iron in the pathogenesis of -induced duodenal ulceration in rats. Am J Physiol Gastrointest Liver Physiol. 2009 Jun;296(6):G1277-86. Epub 2009 Apr 2. Transferrin receptor 1 protein expression was also increased, although mucosal ferroportin and ferritin remained almost unchanged. |
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