Protein Information

Name complex I
Synonyms 39kD; CI 39kD; Complex I; Complex I 39kD; NADH dehydrogenase (ubiquinone) Fe S protein 2 like; NADH ubiquinone oxidoreductase 39 kDa subunit mitochondrial; NADH ubiquinone oxidoreductase 39 kDa subunit; NDUFA 9…

Compound Information

Name ferrous sulfate
CAS sulfuric acid iron(2+) salt (1:1)

Reference List

PubMed Abstract RScore(About this table)
8893143 Tinawi M, Martin KJ, Bastani B: Oral iron absorption test in patients on CAPD: comparison of ferrous sulfate and a polysaccharide ferric complex. Nephron. 1996;74(2):291-4.

Our data suggest that the absorption of both ferrous sulfate and ferric polysaccharide complex is poor in patients on CAPD.
6(0,0,1,1) Details
12210849 Tai KK, Truong DD: Activation of adenosine triphosphate-sensitive potassium channels confers protection against rotenone-induced cell death: therapeutic implications for Parkinson's disease. J Neurosci Res. 2002 Aug 15;69(4):559-66.


Here we show that transient activation of ATP-sensitive potassium channels, a trigger in ischemic preconditioning signaling, confers protection in PC12 cells and SH-SY5Y cells against neurotoxic effect of rotenone and MPTP, mitochondrial complex I inhibitors that have been implicated in the pathogenesis of Parkinson's disease.
1(0,0,0,1) Details
7262022 Schmidt TJ, Sekula BC, Litwack G: The effects of 1,10-phenanthroline on the binding of activated rat hepatic glucocorticoid-receptor complexes to deoxyribonucleic acid-cellulose. Endocrinology. 1981 Sep;109(3):803-12.

Collectively, the data suggest that the activated [3H] TA-receptor complex is a metalloprotein and that the metal ion (s) may be associated directly with the DNA-binding site or may regulate this site indirectly through an allostreic mechanism.
Ferroin (1,10-phenanthroline-ferrous sulfate complex) and 1,7-phenanthroline (nonchelating isomer) also fail to inhibit DNA-cellulose binding.
1(0,0,0,1) Details
17691593 Toblli JE, Brignoli R: Iron (III)-hydroxide polymaltose complex in iron deficiency anemia / review and meta-analysis. Arzneimittelforschung. 2007;57(6A):431-8.

Iron (III)-hydroxide polymaltose complex (IPC) is an iron preparation with non-ionic iron and polymaltose in a stable complex.
By reviewing the published literature an overview is provided of the existing comparative evidence vs. ferrous sulfate as reference.
1(0,0,0,1) Details
1361844 Johnson CA, Rosowski E, Zimmerman SW: A prospective open-label study evaluating the efficacy and adverse reactions of the use of Niferex-150 in ESRD patients receiving EPOGEN. Adv Perit Dial. 1992;8:444-7.

Ferrous sulfate is commonly prescribed, however many patients experience adverse gastrointestinal effects.
Polysaccharide-iron complex (PIC) is an iron supplement containing greater amounts of elemental iron, and may produce fewer adverse effects.
1(0,0,0,1) Details
10398297 Duan W, Mattson MP: Dietary restriction and 2-deoxyglucose administration improve behavioral outcome and reduce degeneration of dopaminergic neurons in models of Parkinson's disease. J Neurosci Res. 1999 Jul 15;57(2):195-206.


The 2-DG treatment suppressed oxidative stress, preserved mitochondrial function, and attenuated cell death in cultured dopaminergic cells exposed to the complex I inhibitor rotenone or Fe2+. 2-DG and DR induced expression of the stress proteins heat-shock protein 70 and glucose-regulated protein 78 in dopaminergic cells, suggesting involvement of these cytoprotective proteins in the neuroprotective actions of 2-DG and DR.
1(0,0,0,1) Details
11751551 Siek G, Lawlor J, Pelczar D, Sane M, Musto J: Direct serum total iron-binding capacity assay suitable for automated analyzers. Clin Chem. 2002 Jan;48(1):161-6.

No interference was seen with common interferants other than ascorbate, deferoxamine, and ferrous sulfate, and only at concentrations well above normal.
The decrease in absorbance (as transferrin extracts iron from the iron-dye complex) is directly proportional to the TIBC.
1(0,0,0,1) Details
19736039 Lu LL, Li YH, Lu XY: Kinetic study of the complexation of gallic acid with Fe (II). Spectrochim Acta A Mol Biomol Spectrosc. 2009 Oct 15;74(3):829-34. Epub 2009 Aug 15.

Kinetic study on the complexation of gallic acid with ferrous sulfate was performed using UV-Vis absorption spectroscopy.
Under the experimental conditions, the stoichiometric composition of the formed complex is 1:1.
1(0,0,0,1) Details
2054264 Kara M, Hasinoff BB, McKay DW, Campbell NR: Clinical and chemical interactions between iron preparations and ciprofloxacin. Br J Clin Pharmacol. 1991 Mar;31(3):257-61.


The formation of a ferric ion-ciprofloxacin complex is probably the cause of the reduction in ciprofloxacin bioavailability in the presence of iron.
1(0,0,0,1) Details
2524660 Mirancea N, Mirancea D, Caloianu-Iordachel M, Toader G, Moldovan L, Negroiu G: The action of the collagen-Fe2+ complex at tissular level. Morphol Embryol. 1989 Jan-Mar;35(1):59-61.


The results showed that the collagen-Fe2+ complex is biocompatible at tissular level and the ferrous iron entered the animal organism on the well-known metabolic pathways.
1(0,0,0,1) Details
7261310 Huisman W: Interference of imferon in colorimetric assays for iron. Clin Chem. 1980 Apr;26(5):635-7.

The freed iron becomes dialyzable, can react with bathophenanthroline, and elutes on a Sephadex G-50 or G-15 column in the same fractions as an ammonium ferrous sulfate.
Imferon (Merrell-National), an iron-dextran complex, is widely used in patients with iron deficiency.
1(0,0,0,1) Details
15349137 Malhotra S, Garg SK, Khullar GK, Malhotra AS, Kondal A, Rana H, Sidhu S: Kinetics of two different iron formulations and their effect on diurnal variation of serum iron levels. Methods Find Exp Clin Pharmacol. 2004 Jul-Aug;26(6):417-20.

Iron polymaltose complex (IPC) is a recently marketed preparation with questionable bioavailability.
We compared the absorption kinetics of IPC with ferrous sulfate.
1(0,0,0,1) Details
107784 Martinez-Torres C, Romano EL, Renzi M, Layrisse M: Fe (III)-EDTA complex as iron fortification. Am J Clin Nutr. 1979 Apr;32(4):809-16.


The iron absorption data from this salt tested with six different food vehicles compared with the absorption of ferrous sulfate administered with the same vehicles indicate that while the mean absorption from ferrous sulfate varies from 2 to 30% according to the food vehicle mixed with the salt, the absorption from Fe (III)-EDTA remains practically the same.
0(0,0,0,0) Details