| Name | xanthine oxidase |
|---|---|
| Synonyms | XDH; XDHA; XO; XOD; XOR; Xanthene dehydrogenase; Xanthine dehydrogenase; Xanthine dehydrogenase/oxidase… |
| Name | ferrous sulfate |
|---|---|
| CAS | sulfuric acid iron(2+) salt (1:1) |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 3111274 | Hiraishi H, Terano A, Ota S, Ivey KJ, Sugimoto T: metabolite-induced cytotoxicity to cultured rat gastric mucosal cells. Am J Physiol. 1987 Jul;253(1 Pt 1):G40-8. -reactive metabolites were generated by 1 mM and 10-100 mU/ml xanthine oxidase. |
3(0,0,0,3) | Details |
| 11520911 | Ravati A, Ahlemeyer B, Becker A, Klumpp S, Krieglstein J: Preconditioning-induced neuroprotection is mediated by reactive species and activation of the transcription factor nuclear factor-kappaB. J Neurochem. 2001 Aug;78(4):909-19. Preconditioning was performed by incubating mixed cultures of neurons and astrocytes from neonatal rat hippocampus with /xanthine oxidase or FeSO4 for 15 min followed by 24 h of recovery which protected the neurons against subsequent staurosporine-induced (200 nM, 24 h) apoptosis. |
3(0,0,0,3) | Details |
| 14741688 | Dombrecht EJ, Cos P, Vanden Berghe D, Van Offel JF, Schuerwegh AJ, Bridts CH, Stevens WJ, De Clerck LS: Selective in vitro antioxidant properties of bisphosphonates. Biochem Biophys Res Commun. 2004 Feb 13;314(3):675-80. Bisphosphonates were tested for their xanthine oxidase and microsomal lipid peroxidation inhibiting capacity. |
2(0,0,0,2) | Details |
| 2553987 | Kaneko M, Lee SL, Wolf CM, Dhalla NS: Reduction of calcium channel antagonist binding sites by free radicals in rat heart. J Mol Cell Cardiol. 1989 Sep;21(9):935-43. Isolated heart membranes were incubated with + xanthine oxidase (a radicals generating system), peroxide (an activated species of or peroxide + Fe2+ (a generating system). |
2(0,0,0,2) | Details |
| 10915642 | Rao RK, Li L, Baker RD, Baker SS, Gupta A: oxidation and PTPase inhibition by peroxide in Caco-2 cell monolayer. Am J Physiol Gastrointest Liver Physiol. 2000 Aug;279(2):G332-40. Treatment with a H (2) O (2) generating system (xanthine oxidase + or H (2) O (2) (20 microM) increased the paracellular permeability. H (2) O (2)-induced permeability was prevented by ferrous sulfate and potentiated by deferoxamine and 1,10-phenanthroline. |
2(0,0,0,2) | Details |
| 9350336 | Chen CS, Chao HT, Pan RL, Wei YH: -induced decline in motility and increase in lipid peroxidation and DNA modification in human sperm. Biochem Mol Biol Int. 1997 Oct;43(2):291-303. We employed the -xanthine oxidase system to produce H2O2 or simply used commercially available H2O2 solution to investigate the effects of exogenous on the motility characteristics and on lipid peroxidation and DNA modification of human sperm. |
1(0,0,0,1) | Details |
| 15804172 | Jubeh TT, Antler S, Haupt S, Barenholz Y, Rubinstein A: Local prevention of oxidative stress in the intestinal epithelium of the rat by adhesive liposomes of superoxide dismutase and tempamine. Mol Pharm. 2005 Jan-Feb;2(1):2-11. Reactive were generated in situ in a closed circulating intestinal loop of the rat from the reaction between and xanthine oxidase in the presence of chelated ferrous sulfate. |
81(1,1,1,1) | Details |
| 8308714 | Rubinstein A, Kakunda A, Kohen R: Protection of the rat jejunal mucosa against oxidative injury by cationized superoxide dismutase. J Pharm Sci. 1993 Dec;82(12):1285-7. Mucosal damage was induced in a closed circulating intestinal loop of the rat either by a mixture of and xanthine oxidase or by a mixture of xanthine oxidase, and chelated ferrous sulfate. |
81(1,1,1,1) | Details |
| 6408899 | Kontos HA, Hess ML: radicals and vascular damage. Adv Exp Med Biol. 1983;161:365-75. Xanthine oxidase plus which produced radical, peroxide, and peroxide plus ferrous sulfate, which produced the free induced sustained dilation, reduced responsiveness to the vasoconstrictor effect of hypocapnia, and destructive lesions of the endothelium and of the vascular smooth muscle. |
31(0,1,1,1) | Details |
| 15591360 | Potineni RV, Peterson DG: Influence of thermal processing conditions on flavor stability in fluid milk: benzaldehyde. J Dairy Sci. 2005 Jan;88(1):1-6. Additionally, PAH and UHT milk samples containing benzaldehyde (with and without ferrous sulfate) were spiked with xanthine oxidase. |
8(0,0,1,3) | Details |
| 12842456 | Chan EL, Murphy JT: Reactive species mediate endotoxin-induced human dermal endothelial NF-kappaB activation. J Surg Res. 2003 May 1;111(1):120-6. HMEC.1 cultures were treated individually with LPS, peroxide, or xanthine oxidase, and ferrous sulfate /XO/Fe (2+)). |
6(0,0,1,1) | Details |
| 14871580 | Je JY, Park PJ, Kim SK: Free radical scavenging properties of hetero-chitooligosaccharides using an ESR spectroscopy. Food Chem Toxicol. 2004 Mar;42(3):381-7. and carbon-centered radicals were generated from -xanthine oxidase reaction, peroxide-ferrous sulfate (Fenton reaction) and azo compound 2,2-azobis-(2-amidinopropane)-hydrochloride (AAPH), respectively. |
6(0,0,1,1) | Details |
| 3918462 | Wei EP, Christman CW, Kontos HA, Povlishock JT: Effects of radicals on cerebral arterioles. Am J Physiol. 1985 Feb;248(2 Pt 2):H157-62. Xanthine oxidase and a combination that produces peroxide and radical, applied topically in anesthetized cats equipped with cranial windows caused arteriolar dilation during application, sustained dilation 1 h after washout, and reduced reactivity to the vasoconstrictive effects of arterial hypocapnia, discrete lesions of the endothelium, and morphological abnormalities of the vascular smooth muscle by electron microscopy. Similar effects were seen in small, but not in large, arterioles during topical application of peroxide or peroxide plus ferrous sulfate, a combination that produces free |
3(0,0,0,3) | Details |
| 17331021 | Inoue OJ, Freeman DE, Wallig MA, Clarkson RB: In vitro effects of reactive metabolites, with and without flunixin meglumine, on equine colonic mucosa. Am J Vet Res. 2007 Mar;68(3):305-12. Incubation conditions included control (no addition) and ROM systems, including addition of 1 mM and 80 mU of xanthine oxidase (to produce the 1 mM H (2) O (2), and 1 mM H (2) O (2) and 0.5 mM ferrous sulfate (to produce the |
6(0,0,1,1) | Details |
| 7564416 | Lin JM, Lin CC, Chen MF, Ujiie T, Takada A: Scavenging effects of Mallotus repandus on active species. J Ethnopharmacol. 1995 Jun;46(3):175-81. (O2.-) and (OH.) were supplied enzymatically from -xanthine oxidase (HPX-XOD) reaction and peroxide-ferrous sulfate (Fenton reaction), respectively, to the assay system. |
6(0,0,1,1) | Details |
| 12517328 | Vaughan JE, Walsh SW: Oxidative stress reproduces placental abnormalities of preeclampsia. . Hypertens Pregnancy. 2002;21(3):205-23. METHODS: We tested this possibility in vitro by exposing a trophoblast-like cell line, ED27, to a combination of (LA, 90 microM) and an oxidizing solution composed of xanthine oxidase and ferrous sulfate (OxLA) for 6 days. |
6(0,0,1,1) | Details |
| 7494543 | Shao Q, Matsubara T, Bhatt SK, Dhalla NS: Inhibition of cardiac sarcolemma Na (+)-K+ ATPase by oxyradical generating systems. Mol Cell Biochem. 1995 Jun 7-21;147(1-2):139-44. The Na (+)-K+ ATPase activity and SH group content were decreased whereas malondialdehyde (MDA) content was increased upon treating the porcine cardiac sarcolemma with plus xanthine oxidase, which is known to generate and other oxyradicals. |
4(0,0,0,4) | Details |
| 8424675 | Giannessi M, Del Corso A, Cappiello M, Voltarelli M, Marini I, Barsacchi D, Garland D, Camici M, Mura U: Thiol-dependent metal-catalyzed oxidation of bovine lens aldose reductase. Arch Biochem Biophys. 1993 Jan;300(1):423-9. The net maximal increase in the enzyme activity was observed with 3 mM 2-mercaptoethanol, 0.3 mM FeSO4, and 0.9 mM EDTA, either with or without 1 mM and 37 mU/ml of xanthine oxidase. |
1(0,0,0,1) | Details |
| 9396461 | Li PF, Dietz R, von Harsdorf R: Differential effect of peroxide and on apoptosis and proliferation of vascular smooth muscle cells. Circulation. 1997 Nov 18;96(10):3602-9. METHODS AND RESULTS: Cultured rat VSMCs were exposed to xanthine oxidase/ (XO/X) or H2O2-Fe (II). |
1(0,0,0,1) | Details |
| 11105916 | Baumber J, Ball BA, Gravance CG, Medina V, Davies-Morel MC: The effect of reactive species on equine sperm motility, viability, acrosomal integrity, mitochondrial membrane potential, and membrane lipid peroxidation. J Androl. 2000 Nov-Dec;21(6):895-902. In order to promote lipid peroxidation, samples were incubated with ferrous sulfate (0.64 mM) and (20 mM) for 2 hours after the X-XO incubation. The objective of this study was to examine the influence of reactive species (ROS), generated through the use of the (X)-xanthine oxidase (XO) system, on equine sperm motility, viability, acrosomal integrity, mitochondrial membrane potential, and membrane lipid peroxidation. |
1(0,0,0,1) | Details |
| 12210849 | Tai KK, Truong DD: Activation of -sensitive channels confers protection against rotenone-induced cell death: therapeutic implications for Parkinson's disease. J Neurosci Res. 2002 Aug 15;69(4):559-66. Pretreatment of PC12 cells with preconditioning stimuli FeSO (4) or /xanthine oxidase also confers protection against rotenone-induced cell death. |
1(0,0,0,1) | Details |
| 11737181 | Gunaydin B, Demiryurek AT: Interaction of lidocaine with reactive and species. Eur J Anaesthesiol. 2001 Dec;18(12):816-22. In cell-free experiments, lidocaine (1 mM) markedly inhibited chemiluminescence of -xanthine oxidase (24 +/- 3%), while it slightly suppressed hypochlorous acid-induced chemiluminescence (9 +/- 2%). |
1(0,0,0,1) | Details |
| 2516241 | Srivastava SK, Ansari NH, Liu S, Izban A, Das B, Szabo G, Bhatnagar A: The effect of oxidants on biomembranes and cellular metabolism. . Mol Cell Biochem. 1989 Nov 23-Dec 19;91(1-2):149-57. Increased Ca2+ may affect proteases and may help in the conversion of xanthine dehydrogenase to xanthine oxidase, consequently increased production of super oxide radicals. By using patch-clamp technique in isolated frog myocytes, we have shown that radicals generated by ferrous sulfate and as well as lipid peroxides such as t-butyl hydroperoxide facilitate the entry of Na+ by oxidizing Na+-channels. |
1(0,0,0,1) | Details |
| 9051661 | O'Regan MH, Song D, VanderHeide SJ, Phillis JW: Free radicals and the ischemia-evoked extracellular accumulation of amino acids in rat cerebral cortex. Neurochem Res. 1997 Mar;22(3):273-80. Xanthine oxidase plus significantly enhanced levels 358 fold over controls during 20 min of four vessel occlusion. Administration of H2O2 plus ferrous sulfate significantly elevated both pre-ischemic amino acid release and ischemia-evoked release. |
1(0,0,0,1) | Details |
| 3025753 | Nagase S, Aoyagi K, Narita M, Tojo S: Active in synthesis. . Nephron. 1986;44(4):299-303. MG synthesis is moderately stimulated by the derived from 3 mM and 0.015 units/ml xanthine oxidase and inhibited by the addition of superoxide dismutase. |
1(0,0,0,1) | Details |
| 2827582 | Vile GF, Winterbourn CC, Sutton HC: Radical-driven Fenton reactions: studies with paraquat, adriamycin, and anthraquinone 6-sulfonate and ATP, ADP, and iron chelates. Arch Biochem Biophys. 1987 Dec;259(2):616-26. Radicals were generated either radiolytically or enzymatically with xanthine oxidase or ferredoxin reductase. |
1(0,0,0,1) | Details |