Protein Information

Name NMDA receptor (protein family or complex)
Synonyms Glutamate [NMDA] receptor; Glutamate [NMDA] receptors; N methyl D aspartate receptor; N methyl D aspartate receptors; NMDA receptor; NMDA receptors

Compound Information

Name ferrous sulfate
CAS sulfuric acid iron(2+) salt (1:1)

Reference List

PubMed Abstract RScore(About this table)
10871701 Rudolph JG, Lemasters JJ, Crews FT: Effects of NMDA and ferrous sulfate on oxidation and cell death in primary neuronal cultures. Neurochem Int. 2000 Nov-Dec;37(5-6):497-507.

To determine the relationship of oxidation to NMDA-receptor mediated neuronal death, we exposed rat primary cortical neuronal cultures to ferrous sulfate and the fluorescent dyes dichlorofluorescin diacetate (H (2) DCF) and propidium iodide (PI) to monitor reactive oxygen species (ROS) and cell death, respectively in the same cultures.
81(1,1,1,1) Details
7477670 Oh S, McCaslin PP: The iron component of sodium nitroprusside blocks NMDA-induced glutamate accumulation and intracellular Ca2+ elevation. Neurochem Res. 1995 Jul;20(7):779-84.

These effects are also independent of cyanide as another Fe II compound, ferrous sulfate (FeSO4) is also able to suppress NMDA-induced elevations of [Ca2+] i.
Collectively, these results indicate that Fe II, independently of NO, has effects on NMDA receptor function.
1(0,0,0,1) Details
12835115 Jara-Prado A, Ortega-Vazquez A, Martinez-Ruano L, Rios C, Santamaria A: Homocysteine-induced brain lipid peroxidation: effects of NMDA receptor blockade, antioxidant treatment, and nitric oxide synthase inhibition. Neurotox Res. 2003;5(4):237-43.

When compared at equimolar concentrations (100 micro M), the oxidative potency of HCY was lower than that of the oxidant ferrous sulfate, similar to that produced by glutamate (Glu) and the mitochondrial toxin 3-nitropropionic acid, and higher than that of the Glu agonists, kainate and quinolinate.
2(0,0,0,2) Details