| Name | CYP2E1 |
|---|---|
| Synonyms | CPE 1; Flavoprotein linked monooxygenase; Xenobiotic monooxygenase; Microsomal monooxygenase; CPE1; CYP2E; CYP2E1; CYP2E1 protein… |
| Name | sulfuric acid |
|---|---|
| CAS | sulfuric acid |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17315539 | Wu WN, McKown LA, Reitz AB: Metabolism of the new anxiolytic agent, a pyrido [1,2-] benzimidazole (PBI) analog (RWJ-53050), in rat and human hepatic S9 fractions, and in dog; identification of cytochrome p450 isoforms mediated in the human microsomal metabolism. Eur J Drug Metab Pharmacokinet. 2006 Oct-Dec;31(4):277-83. The in vitro and in vivo metabolism of RWJ-53050, an anxiolytic agent, was investigated after incubation with rat and human hepatic S9 fractions, and human microsomes and 7 microsomes containing individual human CYP isoforms, CYP1A2, CYP2A6, CYP2C9, CYP2C19, CYP2D6, CYP2E1 and CYP3A4 in the presence of -generating system, and a single oral dose administration to dogs (30 mg/kg). |
1(0,0,0,1) | Details |
| 19881208 | Matsunaga N: [Dosing time based on molecular mechanism of biological clock of hepatic drug metabolic enzyme]. Yakugaku Zasshi. 2009 Nov;129(11):1357-65. is a widely used analgesic drug, and is mainly biotransformed and eliminated as nontoxic conjugates with and sulfuric acid. Only a small portion of the dose is mainly bioactivated by CYP2E1 to N-- imine (NAPQI), a reactive toxic intermediate. |
6(0,0,0,6) | Details |