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Brier S, Carletti E, DeBonis S, Hewat E, Lemaire D, Kozielski F: The marine natural product adociasulfate-2 as a tool to identify the MT-binding region of kinesins. Biochemistry. 2006 Dec 26;45(51):15644-53. Epub 2006 Dec 1.
We have used the marine natural product adociasulfate-2 (AS-2), previously identified as a MT-competitive inhibitor of conventional kinesin, to infer the secondary structure elements forming the MT interface of two human mitotic kinesins, namely, CENP-E and Eg5. |
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