Protein Information

Name ATPase
Synonyms ATP7A; MK; ATPase; Cation transporting ATPase; ATP7A protein; ATPase Cu(2+) transporting alpha polypeptide; Copper pump 1; Copper transporting ATPase 1…

Compound Information

Name sulfuric acid
CAS sulfuric acid

Reference List

PubMed Abstract RScore(About this table)
17588561 Luiz Oliveira Penido M, Resende DM, Vianello MA, Humberto da Silveira Bordin F, Jacinto AA, Dias WD, Montesano MA, Nelson DL, Marcos Zech Coelho P, Vasconcelos EG: A new series of schistosomicide drugs, the alkylaminoalkanethiosulfuric acids, partially inhibit the activity of Schistosoma mansoni ATP diphosphohydrolase. Eur J Pharmacol. 2007 Sep 10;570(1-3):10-7. Epub 2007 Jun 5.


Pre-incubation of worm adult tegument with AAATs derivatives, with small apolar alkyl groups and an apolar alkane portion of 6 or 8 carbon atoms linked to the amino group, inhibited ATPase activity with a Ki 100-1000 microM.
3(0,0,0,3) Details
14656523 Katewa SD, Katyare SS: A simplified method for inorganic phosphate determination and its application for phosphate analysis in enzyme assays. Anal Biochem. 2003 Dec 15;323(2):180-7.


Under the standard assay conditions, interference from acid-labile phosphate as in the case of Na+,K+ ATPase was at the minimum.
2(0,0,0,2) Details
17507208 Zhang L, Lin G, Kovacs B, Jani M, Krajcsi P, Zuo Z: Mechanistic study on the intestinal absorption and disposition of baicalein. Eur J Pharm Sci. 2007 Jul;31(3-4):221-31. Epub 2007 Apr 9.


To identify specific interactions of BG with ABC transporters, ABC transporter-ATPase assays were carried out on membrane vesicles prepared from Sf9 cells overexpressing human MDR1, MRP1, MRP2, MRP3 and MXR.
2(0,0,0,2) Details
17176086 Brier S, Carletti E, DeBonis S, Hewat E, Lemaire D, Kozielski F: The marine natural product adociasulfate-2 as a tool to identify the MT-binding region of kinesins. Biochemistry. 2006 Dec 26;45(51):15644-53. Epub 2006 Dec 1.


AS-2 inhibits both basal and MT-stimulated ATPase activities of CENP-E (IC50 of 8.6 and 1.3 microM, respectively) and Eg5 (IC50 of 3.5 and 5.3 microM, respectively) and is a MT-competitive inhibitor of CENP-E with a Ki of 0.35 microM.
1(0,0,0,1) Details
16872752 Landeira-Fernandez AM, Aquino RS, Mourao PA, de Meis L: Ca2+-transport in sea urchin unfertilized eggs: regulation by endogenous sulfated polysaccharides and K+. Biochim Biophys Acta. 2006 Oct;1760(10):1529-35. Epub 2006 Jun 7.


Previous data from our laboratory showed that the reticulum of the sea cucumber smooth muscle body wall retains both a sarco/endoplasmic reticulum Ca (2+)-ATPase (SERCA) and a sulfated polysaccharide.
1(0,0,0,1) Details
16884297 Reddie KG, Roberts DR, Dore TM: Inhibition of kinesin motor proteins by adociasulfate-2. J Med Chem. 2006 Aug 10;49(16):4857-60.


Instead, a rodlike aggregate that mimics microtubules is complexed with kinesin and inhibits its ATPase activity.
1(0,0,0,1) Details
19076065 Grondahl F, Tveit H, Prydz K: Neutralization of endomembrane compartments in epithelial MDCK cells affects proteoglycan synthesis in the apical secretory pathway. Biochem J. 2009 Mar 15;418(3):517-28.


We therefore investigated how neutralization of endomembrane compartments with the vacuolar H (+)-ATPase inhibitor Baf A (1) (bafilomycin A (1)) affected GAG synthesis and PG sorting in MDCK cells.
1(0,0,0,1) Details
12175672 Holzinger A, Lutz-Meindl U: Kinesin-like proteins are involved in postmitotic nuclear migration of the unicellular green alga Micrasterias denticulata. Cell Biol Int. 2002;26(8):689-97.


AMP-PNP, a non hydrolyseable ATP analogue or the general ATPase inhibitors calyculin A and sodium orthovanadate also disturb nuclear migration.
1(0,0,0,1) Details