| Name | Factor Xa |
|---|---|
| Synonyms | Coagulation factor X; F10; Fx; Coagulation factor X precursor; FXA; Factor Xa; Prothrombinase; Stuart factor… |
| Name | sulfuric acid |
|---|---|
| CAS | sulfuric acid |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11881992 | Gunnarsson GT, Desai UR: Designing small, nonsugar activators of antithrombin using hydropathic interaction analyses. J Med Chem. 2002 Mar 14;45(6):1233-43. Conformational activation of antithrombin is a critical mechanism for the inhibition of factor Xa, a proteinase of the blood coagulation cascade, and is typically achieved with a polyanionic polysaccharide clinically used for anticoagulation. |
3(0,0,0,3) | Details |
| 12238925 | Gunnarsson GT, Desai UR: Interaction of designed sulfated flavanoids with antithrombin: lessons on the design of organic activators. J Med Chem. 2002 Sep 26;45(20):4460-70. Recently, we designed (-)- (ECS), the first small nonsaccharide molecule, as an activator of antithrombin for the accelerated inhibition of factor Xa, a key proteinase of the coagulation cascade (Gunnarsson, G. |
3(0,0,0,3) | Details |
| 12639557 | Gunnarsson GT, Desai UR: Exploring new non-sugar sulfated molecules as activators of antithrombin. Bioorg Med Chem Lett. 2003 Feb 24;13(4):679-83. New non-sugar, small, sulfated molecules, based on our de novo rationally designed activator (-)- (ECS), were investigated to bind and activate antithrombin, an inhibitor of plasma coagulation enzyme factor Xa. |
2(0,0,0,2) | Details |
| 18669628 | de Agostini AI, Dong JC, de Vantery Arrighi C, Ramus MA, Dentand-Quadri I, Thalmann S, Ventura P, Ibecheole V, Monge F, Fischer AM, HajMohammadi S, Shworak NW, Zhang L, Zhang Z, Linhardt RJ: Human follicular fluid contains abundant 3-O-sulfated chains with anticoagulant activity. J Biol Chem. 2008 Oct 17;283(42):28115-24. Epub 2008 Jul 31. These antithrombin-binding chains contain more than 6% 3-O-sulfated residues, convey an anticoagulant activity of 2.5 IU/ml to human follicular fluid, and have an anti-Factor Xa specific activity of 167 IU/mg. |
1(0,0,0,1) | Details |