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Luiz Oliveira Penido M, Resende DM, Vianello MA, Humberto da Silveira Bordin F, Jacinto AA, Dias WD, Montesano MA, Nelson DL, Marcos Zech Coelho P, Vasconcelos EG: A new series of schistosomicide drugs, the alkylaminoalkanethiosulfuric acids, partially inhibit the activity of Schistosoma mansoni ATP diphosphohydrolase. Eur J Pharmacol. 2007 Sep 10;570(1-3):10-7. Epub 2007 Jun 5.
Treatment of parasite tegument with 5 mM iodoacetamide or 1 mM dithiothreitol protected ATPase and ADPase activities against inhibition by AAATs, corroborating the participation of disulfide interchange in the AAATs mechanism. |
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