Protein Information

Name RNase
Synonyms HP RNase; Ribonuclease; Ribonuclease A; Pancreatic ribonuclease; Pancreatic ribonuclease precursor; RIB 1; RIB1; RNASE1…

Compound Information

Name sulfuric acid
CAS sulfuric acid

Reference List

PubMed Abstract RScore(About this table)
12649287 Smith BD, Soellner MB, Raines RT: Potent inhibition of ribonuclease A by oligo (vinylsulfonic acid). J Biol Chem. 2003 Jun 6;278(23):20934-8. Epub 2003 Mar 20.

The phosphonic acid and sulfuric acid analogs of OVS are also potent inhibitors although slightly less effective.
6(0,0,0,6) Details
17254600 Menichelli E, Isel C, Oubridge C, Nagai K: Protein-induced conformational changes of RNA during the assembly of human signal recognition particle. J Mol Biol. 2007 Mar 16;367(1):187-203. Epub 2006 Dec 24.


SRP68/72 binding also protects the SRP54 binding site (helix 8 asymmetric loop) from chemical modification and RNase cleavage, whereas, in the presence of both SRP19 and SRP68/72, the long strand of helix 8 asymmetric loop becomes readily accessible to chemical and enzymatic probes.
1(0,0,0,1) Details