Protein Information

Name progesterone receptors
Synonyms NR3C3; PGR; PR; Progesterone receptor; Progesterone receptors

Compound Information

Name DMPA
CAS

Reference List

PubMed Abstract RScore(About this table)
16246667 Ildgruben A, Sjoberg I, Hammarstrom ML, Backstrom T: Steroid receptor expression in vaginal epithelium of healthy fertile women and influences of hormonal contraceptive usage. Contraception. 2005 Nov;72(5):383-92. Epub 2005 Aug 9.

RESULTS: Progesterone receptor expression was markedly down-regulated and significantly reduced in DMPA users compared to controls, COC and LNG users.
82(1,1,1,2) Details
16311300 Jain JK, Li A, Yang W, Minoo P, Felix JC: Effects of mifepristone on proliferation and apoptosis of human endometrium in new users of medroxyprogesterone acetate. Hum Reprod. 2006 Mar;21(3):798-809. Epub 2005 Nov 25.

RESULTS: Administration of mifepristone to DMPA-exposed endometrium for 1 week significantly increased endometrial expression of Ki-67 (MKI67), estrogen receptor (ER) alpha and progesterone receptors A and B (PRAB) and decreased the number of TUNEL-positive and caspase-3 (CASP3)-active cells in the endometrial stroma.
7(0,0,1,2) Details
12678156 Chotnopparatpattara P, Taneepanichskul S, Treratanachat S, Charuruks N: Relationship between progesterone receptor level in endometrium and bleeding pattern in depot medroxyprogesterone acetate users. J Med Assoc Thai. 2003 Feb;86(2):172-7.

Bleeding disturbance is the major reason for discontinuation among depot medroxyprogesterone acetate (DMPA) users.
2(0,0,0,2) Details
14668006 Jain JK, Nicosia AF, Nucatola DL, Lu JJ, Kuo J, Felix JC: Mifepristone for the prevention of breakthrough bleeding in new starters of depo-medroxyprogesterone acetate. Steroids. 2003 Nov;68(10-13):1115-9.

Depo-medroxyprogesterone acetate (DMPA) is an effective injectable contraceptive with worldwide availability.
Mifepristone is a progesterone receptor antagonist that has been demonstrated to decrease BTB caused by the levonorgestrel subdermal implant (Norplant).
2(0,0,0,2) Details
14998949 Sereepapong W, Chotnopparatpattara P, Taneepanichskul S, Markham R, Russell P, Fraser IS: Endometrial progesterone and estrogen receptors and bleeding disturbances in depot medroxyprogesterone acetate users. Hum Reprod. 2004 Mar;19(3):547-52. Epub 2004 Jan 29.

BACKGROUND: Depot medroxyprogesterone acetate (DMPA) is a very popular hormonal contraceptive.
Endometrial biopsies were collected for immunohistochemical study of progesterone receptor A plus B (PRAB) and B alone (PRB) and estrogen receptor alpha (ERalpha) and beta (ERbeta) expression.
1(0,0,0,1) Details
17094978 Jain JK, Li A, Yang W, Minoo P, Felix JC: Mifepristone alters expression of endometrial steroid receptors and their cofactors in new users of medroxyprogesterone acetate. Fertil Steril. 2007 Jan;87(1):8-23. Epub 2006 Nov 7.

OBJECTIVE: To evaluate the effect of mifepristone on the expression of endometrial steroid receptors and their co-factors in depot medroxyprogesterone acetate (DMPA) users.
MAIN OUTCOME MEASURE (S): The expression of estrogen receptor subtypes alpha and beta (ERalpha and ERbeta), progesterone receptors A and B (PRAB and PRB), and androgen receptor messenger RNA and protein was detected by real-time polymerase chain reaction and immunohistochemistry, respectively.
1(0,0,0,1) Details