Protein Information

Name superoxide dismutase
Synonyms IPO B; Indophenoloxidase B; MNSOD; Manganese superoxide dismutase; Manganese containing superoxide dismutase; Mangano superoxide dismutase; Mn superoxide dismutase; Mn SOD…

Compound Information

Name glyphosate
CAS

Reference List

PubMed Abstract RScore(About this table)
20045496 George J, Prasad S, Mahmood Z, Shukla Y: Studies on glyphosate-induced carcinogenicity in mouse skin: a proteomic approach. J Proteomics. 2010 Mar 10;73(5):951-64. Epub 2010 Jan 4.

Among them, 9 proteins (translation elongation factor eEF-1 alpha chain, carbonic anhydrase III, annexin II, calcyclin, fab fragment anti-VEGF antibody, peroxiredoxin-2, superoxide dismutase [Cu-Zn], stefin A3, and calgranulin-B) were common and showed similar expression pattern in glyphosate and TPA-treated mouse skin.
12(0,0,2,2) Details
18790555 Contardo-Jara V, Klingelmann E, Wiegand C: Bioaccumulation of glyphosate and its formulation Roundup Ultra in Lumbriculus variegatus and its effects on biotransformation and antioxidant enzymes. Environ Pollut. 2009 Jan;157(1):57-63. Epub 2008 Sep 14.

Antioxidant enzyme superoxide dismutase was significantly increased by glyphosate but in particular by Roundup Ultra exposure indicating oxidative stress.
6(0,0,1,1) Details
18755596 Ahsan N, Lee DG, Lee KW, Alam I, Lee SH, Bahk JD, Lee BH: Glyphosate-induced oxidative stress in rice leaves revealed by proteomic approach. Plant Physiol Biochem. 2008 Dec;46(12):1062-70. Epub 2008 Jul 19.

An increased accumulation of antioxidant enzymes including ascorbate peroxidase, glutathione S-transferase, thioredoxin h-type, nucleoside diphosphate kinase 1, peroxiredoxin and a superoxide dismutase [Cu-Zn] chloroplast precursor in the glyphosate-treated sample suggests that a glyphosate treatment possibly generates oxidative stress in plants.
6(0,0,1,1) Details
11589039 Totskii VN, D'iachenko LF, Toptikov VA, Miros' SL, Polodienko OB: [Changes of gene expression in Solanum tuberosum L. as a result of transgenes]. Tsitol Genet. 2001 Jan-Feb;35(1):22-7.

Potato plants of various cultivars, transformed using Agrobacterium tumefaciens with pGV941 plasmid, differed from control plants in glyphosate herbicide tolerance, tryptophane content, intensity of callusogenesis, microtuber formation in vitro and multimolecular forms of peroxidase (EC 1.11.1.7) and superoxide dismutase (EC 1.15.1.11).
6(0,0,1,1) Details
19910015 Modesto KA, Martinez CB: Roundup causes oxidative stress in liver and inhibits acetylcholinesterase in muscle and brain of the fish Prochilodus lineatus. Chemosphere. 2010 Jan;78(3):294-9. Epub 2009 Nov 11.


Fish exposed to RD for 24h showed reduction on superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities, and increased glutathione (GSH) content.
1(0,0,0,1) Details
19450865 Lushchak OV, Kubrak OI, Storey JM, Storey KB, Lushchak VI: Low toxic herbicide Roundup induces mild oxidative stress in goldfish tissues. Chemosphere. 2009 Aug;76(7):932-7. Epub 2009 May 17.

The formulation of Roundup consists of the herbicide glyphosate as the active ingredient with polyethoxylene amine added as a surfactant.
Roundup exposure generally suppressed the activities of superoxide dismutase (SOD), glutathione S-transferase (GST), glutathione reductase and glucose-6-phosphate dehydrogenase in fish tissues.
1(0,0,0,1) Details
17987383 Costa MJ, Monteiro DA, Oliveira-Neto AL, Rantin FT, Kalinin AL: Oxidative stress biomarkers and heart function in bullfrog tadpoles exposed to Roundup Original. Ecotoxicology. 2008 Apr;17(3):153-63. Epub 2007 Nov 7.

Oxidative stress biomarkers, in vivo heart rate (f (H)), and contraction dynamics of ventricle strips of bullfrog (Lithobates catesbeiana) tadpoles were evaluated after 48 h of exposure to a sub-lethal concentration (1 ppm) of the herbicide Roundup Original (glyphosate 41%).
The activities of the antioxidant enzymes superoxide dismutase and catalase were increased in the liver and decreased in muscle, while oxidative damage to lipids increased above control values in both tissues, showing that the generation of reactive oxygen species and oxidative stress are involved in the toxicity induced by Roundup.
1(0,0,0,1) Details
20027135 Slaninova A, Smutna M, Modra H, Svobodova Z: A review: oxidative stress in fish induced by pesticides. Neuro Endocrinol Lett. 2009;30 Suppl 1:2-12.

Butachlor causes increased activity of superoxide dismutase -catalase system in the kidney.
Low concentration of glyphosate can cause mild oxidative stress.
1(0,0,0,1) Details