Protein Information

Name Acetylcholinesterase
Synonyms ACHE; ACHE protein; AChE; ARACHE; AcChoEase; Acetylcholine acetylhydrolase; Acetylcholinesterase; Acetylcholinesterase isoform E4 E6 variant…

Compound Information

Name glyphosate
CAS

Reference List

PubMed Abstract RScore(About this table)
17716950 Glusczak L, Miron Ddos S, Moraes BS, Simoes RR, Schetinger MR, Morsch VM, Loro VL: Acute effects of glyphosate herbicide on metabolic and enzymatic parameters of silver catfish (Rhamdia quelen). Comp Biochem Physiol C Toxicol Pharmacol. 2007 Nov;146(4):519-24. Epub 2007 Jun 19.

The present results showed that in 96 h, glyphosate changed AChE activity, metabolic parameters and TBARS production.
31(0,1,1,1) Details
16174533 Glusczak L, dos Santos Miron D, Crestani M, Braga da Fonseca M, de Araujo Pedron F, Duarte MF, Vieira VL: Effect of glyphosate herbicide on acetylcholinesterase activity and metabolic and hematological parameters in piava (Leporinus obtusidens). Ecotoxicol Environ Saf. 2006 Oct;65(2):237-41. Epub 2005 Sep 19.
9(0,0,1,4) Details
20112104 Salbego J, Pretto A, Gioda CR, de Menezes CC, Lazzari R, Radunz Neto J, Baldisserotto B, Loro VL: Herbicide Formulation with Glyphosate Affects Growth, Acetylcholinesterase Activity, and Metabolic and Hematological Parameters in Piava (Leporinus obtusidens). Arch Environ Contam Toxicol. 2010 Jan 30.
8(0,0,1,3) Details
11281253 El-Demerdash FM, Yousef MI, Elagamy EI: Influence of paraquat, glyphosate, and cadmium on the activity of some serum enzymes and protein electrophoretic behavior (in vitro). J Environ Sci Health B. 2001 Jan;36(1):29-42.

In vitro study for the determination of the toxicity of some pesticides (glyphospate and paraquat) and cadmium chloride (CdCl2) on the activities of serum acetylcholinesterase (AChE), lactate dehydrogenase (LDH), aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (AlP), and acid phosphatase (AcP) is described.
3(0,0,0,3) Details
8415873 Marrs TC: Organophosphate poisoning. Pharmacol Ther. 1993;58(1):51-66.

The cholinergic syndrome is caused by acetylcholinesterase inhibition, and diagnosis is based on the clinical signs and symptoms as well as the measurement of inhibition of erythrocyte acetylcholinesterase and/or plasma cholinesterase activity.
Certain OPs are exploited for their anticholinesterase effects, including defoliants such as 'DEF', herbicides such as glyphosate, fire retardants and industrial intermediates.
1(0,0,0,1) Details
15620756 Rendon-von Osten J, Ortiz-Arana A, Guilhermino L, Soares AM: In vivo evaluation of three biomarkers in the mosquitofish (Gambusia yucatana) exposed to pesticides. Chemosphere. 2005 Feb;58(5):627-36.

In this study, the acute toxicity and the in vivo effects of commercial chlorpyrifos, carbofuran and glyphosate formulations on cholinesterase (ChE), glutathione S-transferase (GST) and lactate dehydrogenase (LDH) activities of the mosquitofish (Gambusia yucatana) were investigated.
The results obtained suggest that the enzyme present in both head and muscle of G. yucatana is mainly acetylcholinesterase (AChE).
1(0,0,0,1) Details
19910015 Modesto KA, Martinez CB: Roundup causes oxidative stress in liver and inhibits acetylcholinesterase in muscle and brain of the fish Prochilodus lineatus. Chemosphere. 2010 Jan;78(3):294-9. Epub 2009 Nov 11.

4(0,0,0,4) Details
15719990 Osten JR, Soares AM, Guilhermino L: Black-bellied whistling duck (Dendrocygna autumnalis) brain cholinesterase characterization and diagnosis of anticholinesterase pesticide exposure in wild populations from Mexico. Environ Toxicol Chem. 2005 Feb;24(2):313-7.

The pesticides used to control pests of this crop mainly are carbofuran, chlorpyrifos, and glyphosate.
We found that acetylcholinesterase (AChE) seems to be the predominant ChE form in the biological fraction analyzed.
1(0,0,0,1) Details
2005670 Tominack RL, Yang GY, Tsai WJ, Chung HM, Deng JF: Taiwan National Poison Center survey of glyphosate--surfactant herbicide ingestions. J Toxicol Clin Toxicol. 1991;29(1):91-109.

0(0,0,0,0) Details