Protein Information

Name acetolactate synthase
Synonyms Acetolactate synthase; OR10B1P

Compound Information

Name glyphosate
CAS

Reference List

PubMed Abstract RScore(About this table)
20043233 Das M, Reichman JR, Haberer G, Welzl G, Aceituno FF, Mader MT, Watrud LS, Pfleeger TG, Gutierrez RA, Schaffner AR, Olszyk DM: A composite transcriptional signature differentiates responses towards closely related herbicides in Arabidopsis thaliana and Brassica napus. Plant Mol Biol. 2010 Mar;72(4-5):545-56. Epub 2009 Dec 31.

One herbicide contained glyphosate, which targets 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS), while the other four herbicides contain different acetolactate synthase (ALS) inhibiting compounds.
81(1,1,1,1) Details
18029803 McNaughton J, Roberts M, Smith B, Rice D, Hinds M, Schmidt J, Locke M, Brink K, Bryant A, Rood T, Layton R, Lamb I, Delaney B: Comparison of broiler performance when fed diets containing event DP-356O43-5 (Optimum GAT), nontransgenic near-isoline control, or commercial reference soybean meal, hulls, and oil. Poult Sci. 2007 Dec;86(12):2569-81.

The expression products of these genes are the glyphosate acetyltransferase 4601 and acetolactate synthase proteins, respectively.
37(0,1,2,2) Details
19603180 Yu Q, Abdallah I, Han H, Owen M, Powles S: Distinct non-target site mechanisms endow resistance to glyphosate, ACCase and ALS-inhibiting herbicides in multiple herbicide-resistant Lolium rigidum. Planta. 2009 Sep;230(4):713-23. Epub 2009 Jul 15.

This study investigates mechanisms of multiple resistance to glyphosate, acetyl-coenzyme A carboxylase (ACCase) and acetolactate synthase (ALS)-inhibiting herbicides in two Lolium rigidum populations from Australia.
31(0,1,1,1) Details
19280593 Gressel J: Crops with target-site herbicide resistance for Orobanche and Striga control. Pest Manag Sci. 2009 May;65(5):560-5.

Such target-site resistances have allowed foliar applications of herbicides inhibiting enol-pyruvylshikimate phosphate synthase (EPSPS) (glyphosate), acetolactate synthase (ALS) (e.g. chlorsulfuron, imazapyr) and dihydropteroate synthase (asulam) for Orobanche control in experimental conditions with various crops.
81(1,1,1,1) Details
12723887 Miller RP, Martinson KB, Sothern RB, Durgan BR, Gunsolus JL: Circadian response of annual weeds in a natural setting to high and low application rates of four herbicides with different modes of actions. Chronobiol Int. 2003 Mar;20(2):299-324.

Four herbicides [glyphosate (GLYT), an amino acid synthesis inhibitor; glufosinate (GLUF), a glutamine synthetase inhibitor; fomesafen (FOME), a protoporphyrinogen oxidase inhibitor, and chlorimuron ethyl (CLIM), an acetolactate synthase inhibitor] were used to examine the influence of time of day of application on the control of a variety of annual broadleaf weeds in field studies conducted in Minnesota (five studies on GLYT and GLUF, three studies on FOME and CLIM).
31(0,1,1,1) Details
19524635 Appenzeller LM, Munley SM, Hoban D, Sykes GP, Malley LA, Delaney B: Subchronic feeding study of grain from herbicide-tolerant maize DP-O9814O-6 in Sprague-Dawley rats. Food Chem Toxicol. 2009 Sep;47(9):2269-80. Epub 2009 Jun 12.

Metabolic inactivation of the herbicidal active ingredient glyphosate was conferred by genomic integration and expression of a gene-shuffled acetylase coding sequence, gat4621, from Bacillus licheniformis; tolerance to acetolactate synthase (ALS) inhibiting herbicides was conferred by overexpression of a modified allele (zm-hra) of the endogenous maize ALS enzyme that is resilient to inactivation.
31(0,1,1,1) Details
19922622 Rao SS, Mamadou L, McConnell M, Polisetty R, Kwanyuen P, Hildebrand D: Non-antibiotic selection systems for soybean somatic embryos: the lysine analog aminoethyl-cysteine as a selection agent. BMC Biotechnol. 2009 Nov 18;9:94.

RESULTS: When tested against different alternate selection agents our studies show that 0.16 microg/mL glufosinate, 40 mg/L isopropylamine-glyphosate, 0.5 mg/mL (S-(2 aminoethyl)-L-cysteine) (AEC) and the acetolactate synthase (ALS) inhibitors Exceed and Synchrony both at 150 microg/mL inhibited soybean somatic embryo growth.
31(0,1,1,1) Details
19038812 McNaughton J, Roberts M, Smith B, Rice D, Hinds M, Rood T, Layton R, Lamb I, Delaney B: Comparison of broiler performance and carcass yields when fed diets containing transgenic maize grains from event DP-O9814O-6 (Optimum GAT), near-isogenic control maize grain, or commercial reference maize grains. Poult Sci. 2008 Dec;87(12):2562-72.

The expressed GAT4621 and ZM-HRA proteins confer tolerance to the herbicidal active ingredient glyphosate and acetolactate synthase-inhibiting herbicides, respectively.
31(0,1,1,1) Details
19918955 Orcaray L, Igal M, Marino D, Zabalza A, Royuela M: The possible role of quinate in the mode of action of glyphosate and acetolactate synthase inhibitors. Pest Manag Sci. 2010 Mar;66(3):262-9.
31(0,1,1,1) Details
12477382 Kleter GA, Peijnenburg AA: Screening of transgenic proteins expressed in transgenic food crops for the presence of short amino acid sequences identical to potential, IgE - binding linear epitopes of allergens. BMC Struct Biol. 2002 Dec 12;2:8. Epub 2002 Dec 12.

Only a limited number of identical stretches shared by transgenic proteins (papaya ringspot virus coat protein, acetolactate synthase GH50, and glyphosate oxidoreductase) and allergenic proteins could be identified as (part of) potential linear epitopes.
6(0,0,1,1) Details
15713032 Van Eerd LL, Stephenson GR, Kwiatkowski J, Grossmann K, Hall JC: Physiological and biochemical characterization of quinclorac resistance in a false cleavers (Galium spurium L.) biotype. J Agric Food Chem. 2005 Feb 23;53(4):1144-51.

There was no difference between herbicide resistant (R) and susceptible (S) false cleavers biotypes in response to 2,4-D, clopyralid, glyphosate, glufosinate-ammonium, or bentazon.
On the basis of GR (50) (growth reduction of 50%) or LD (50) (lethal dose to 50% of tested plants) values, the R biotype was highly resistant to the acetolactate synthase (ALS) inhibitor, thifensulfuron-methyl (GR (50) resistance ratio R/S = 57), and quinolinecarboxylic acids (quinclorac R/S = 46), resistant to MCPA (R/S = 12), and moderately resistant to the auxinic herbicides picloram (R/S = 3), dicamba (R/S = 3), fluroxypyr (R/S = 3), and triclopyr (R/S = 2).
1(0,0,0,1) Details
17315272 Kuk YI, Bugos NR: Cross-resistance profile of mesosulfuron-methyl-resistant Italian ryegrass in the southern United States. Pest Manag Sci. 2007 Apr;63(4):349-57.

This study was conducted to determine the resistance pattern of diclofop-resistant ryegrass accessions from the southern United States to mesosulfuron-methyl, a recently commercialized herbicide for ryegrass control in wheat; to determine the cross-resistance pattern of a Lolium multiflorum Lam. (Italian ryegrass) accession, 03-1, to acetolactate synthase (ALS) and acetyl-CoA carboxylase (ACCase) inhibitors; and to determine the resistance mechanism of Italian ryegrass to mesosulfuron-methyl.
Accession 03-1, however, did not show multiple resistance to the ACCase inhibitor herbicides diclofop, fluazifop, clethodim, sethoxydim and pinoxaden, nor to glyphosate.
1(0,0,0,1) Details
14620047 Osuna MD, Fischer AJ, De Prado R: Herbicide resistance in Aster squamatus conferred by a less sensitive form of acetolactate synthase. Pest Manag Sci. 2003 Nov;59(11):1210-6.

Control of A squamatus using alternative herbicides was poor with clopyralid, intermediate with quinclorac, amitrole and MCPA, and excellent with 2,4-D, glufosinate and glyphosate.
1(0,0,0,1) Details
19413364 Olszyk D, Pfleeger T, Lee EH, Plocher M: Pea (Pisum sativum) seed production as an assay for reproductive effects due to herbicides. Environ Toxicol Chem. 2009 Sep;28(9):1920-9.


Plants were treated with a variety of herbicides (dicamba, clopyralid, glufosinate, glyphosate, 2-methyl-4-chlorophenoxyacetic acid, primisulfuron, or sulfometuron) at below standard field application rates applied at a vegetative stage of growth (approximately 14 d after emergence) or at flowering (approximately 20 d after emergence).
0(0,0,0,0) Details